Androgen Receptor Gene CAG Repeat Polymorphism Regulates the Metabolic Effects of Testosterone Replacement Therapy in Male Postsurgical Hypogonadotropic Hypogonadism

Table 1

General and hormonal characteristics of studied subjects.

General characteristics
Age (years)	55.66±8.64
Duration of hypogonadism (months)	8.46±1.88
Number of AR gene CAG triplets	18.13±3.41
Hormonal characteristics
	Time 0	Recovery phase	Δ	𝑃^+++
FSH (IU/L)	0.90 (0.70–1.10)	0.70 (0.50–0.90)	−0.40 (−0.60–0.20)	NS
LH (IU/L)	0.92±0.40	0.78±0.26	−0.14±0.37	NS
Total testosterone (ng/mL)	1.53±0.52	3.96±0.36	2.42±0.70	<0.001
Estradiol (pg/mL)	7.66±1.95	32.80±10.31	25.13±11.13	<0.001
FT3 (pg/mL)	3.24±0.50	3.11±0.46	−0.12±0.74	NS
FT4 (ng/dL)	1.24±0.28	1.33±0.18	0.08±0.40	NS
Cortisol (mcg/dL)	14.70 (12–16.80)	13.50 (11.40–17.20)	0.80 (−5–1.5)	NS
IGF-1 (ng/mL)	34.93±7.59	153.13±41.05	118.20±43.73	<0.001
Prolactin (ng/mL)	6.82±2.97	7.35±3.17	0.52±4.86	NS

Values are expressed as median (interquartile range) or mean ± standard deviation.
⁺⁺⁺Statistical comparison between time 0 and recovery phase.
AR: androgen receptor; Δ: variation; FSH: follicle-stimulating hormone; LH: luteinizing hormone; FT3: free T3; FT4: free T4; IGF-1: insulin-like growth factor-1; NS: not significant.