Androgen Receptor Gene CAG Repeat Polymorphism Regulates the Metabolic Effects of Testosterone Replacement Therapy in Male Postsurgical Hypogonadotropic Hypogonadism

Table 3

Pearson correlations of statistically significant hormonal variations between the two phases and number of AR gene CAG triplets with CVRFs variations.

	Δ-Testosterone	Δ-Estradiol	Δ-IGF-1	Number of AR gene CAG triplets
Δ-Weight	r: −0.617	NS	NS	r: 0.755
	𝑃: 0.014			𝑃: 0.001
Δ-Waist	r: −0.633	NS	NS	r: 0.685
	𝑃: 0.011			𝑃: 0.005
Δ-Glycaemia	r: −0.758	NS	NS	r: 0.938
	𝑃: 0.001			𝑃<0.001
Δ-HbA1c	r: −0.715	NS	NS	r: 0.921
	𝑃: 0.003			𝑃<0.001
Δ-Total cholesterol	r: −0.750	NS	NS	r: 0.726
	𝑃: 0.001			𝑃: 0.002
Δ-HDL cholesterol	r: 0.838	NS	NS	r: −0.958
	𝑃<0.001			𝑃<0.001
Δ-LDL cholesterol	r: −0.840	NS	NS	r: 0.856
	𝑃<0.001			𝑃<0.001
Δ-Triglycerides	r: −0.757	NS	NS	r: 0.921
	𝑃: 0.001			𝑃<0.001
Δ-HOMA-IR	r: −0.902	NS	NS	r: 0.937
	𝑃<0.001			𝑃<0.001
Δ-SBP	r: −0.801	NS	NS	r: 0.935
	𝑃<0.001			𝑃<0.001
Δ-DBP	r: −0.828	NS	NS	r: 0.965
	𝑃<0.001			𝑃<0.001

AR: androgen receptor; CVRFs: cardiovascular risk factors; Δ: variation; IGF-1: insulin-like growth factor-1; HbA1C: glycated hemoglobin; HDL: high-density lipoprotein; LDL: low-density lipoprotein; HOMA-IR: homeostasis model assessment of insulin resistance; SBP: systolic blood pressure; DBP: diastolic blood pressure; NS: not significant.