Androgen Receptor Gene CAG Repeat Polymorphism Regulates the Metabolic Effects of Testosterone Replacement Therapy in Male Postsurgical Hypogonadotropic Hypogonadism
Table 4
Influence of AR gene CAG repeat length on metabolic parameters.
AR gene CAG repeat length
Unstandardized coefficient (95% CI)+++
-Weight (kg)
0.454 (0.023–0.885)
0.041
-Waist (cm)
0.218 ((−0.125)–(0.561))
NS
-Glycaemia (mg/dL)
1.970 (1.195–2.745)
<0.001
-HbA1c (%)
0.038 (0.022–0.053)
<0.001
-Total cholesterol (mg/dL)
1.414 ((−1.562)–(4.390))
NS
-HDL cholesterol (mg/dL)
−1.817 ((−2.487)–(−1.147))
<0.001
-LDL cholesterol (mg/dL)
2.845 ((−0.005)–(5.696))
0.050
-Triglycerides (mg/dL)
1.927 (1.023–2.832)
<0.001
-HOMA-IR
0.349 (0.177–0.520)
<0.001
-SBP (mmHg)
2.453 (1.333–3.574)
<0.001
-DBP (mmHg)
1.671 (1.134–2.209)
<0.001
+++: adjusted for -testosterone; AR: androgen receptor; CI: confidence interval; : variation; HbA1c: glycated hemoglobin; HDL: high-density lipoprotein; LDL: low-density lipoprotein; HOMA-IR: homeostasis model assessment of insulin resistance; SBP: systolic blood pressure; DBP: diastolic blood pressure; NS: not significant.
