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International Journal of Endocrinology
Volume 2013, Article ID 819584, 6 pages
Research Article

Assessment of Carotid Atherosclerosis in Type 2 Diabetes Mellitus Patients with Microalbuminuria by High-Frequency Ultrasonography

1Department of Diagnostic Ultrasound, Second Affiliated Hospital of Dalian Medical University, 467 Zhongshan Road, Dalian 116023, China
2Department of Diagnostic Ultrasound, Xin Hua Hospital of Dalian University, Dalian 116023, China
3Department of Endocrinology, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China

Received 5 December 2012; Accepted 21 February 2013

Academic Editor: Ilias Migdalis

Copyright © 2013 Yu-Hong Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study is to evaluate carotid atherosclerosis in patients of type 2 diabetes mellitus with microalbuminuria (MA) by high-frequency ultrasonography. Two hundred and fifty patients of type 2 diabetes mellitus were divided into two groups according to urinary albumin excretion rate (UAER): normoalbuminuria group (130 cases) and microalbuminuria group (120 cases). The intimal-medial thickness (IMT) and the atherosclerotic plaques of carotid artery were observed in both groups by high-frequency ultrasound. Fasting blood glucose (FBG), hemoglobin A1c, and lipid profiles were measured. The values of IMT of microalbuminuria group were significantly higher than those of normoalbuminuria group ( ). In univariate analysis, IMT was positively and significantly associated with age ( , ), waist circumference ( , ), body mass index ( , ), systolic blood pressure ( , ), UAER ( , ), HbA1c ( , ) and, duration of diabetes ( , ). In multivariate linear regression analysis, UAER and HbA1c were independent predictors of IMT ( for all). In the two groups, the rate of soft plaques was higher than that of dense plaques and calcified plaques. In conclusion, there is a significant association between microalbuminuria and IMT which is regarded as the early sign of carotid atherosclerosis in type 2 diabetic patients.