Novel Adipokines and Bone Metabolism

Table 1

Relation between adipokines and bone metabolism.

Adipokines	Osteogenic	Osteoclastic	Relationship with BMD
Adiponectin	Promotes the MSCs osteogenesis and osteoblast maturation [4–8]	Inhibits the osteoclastogenesis and osteoclastic activity [8–10]	Negative related with the BMD; a predictor of osteoporotic fractures in certain population [10–12, 59–63]
Leptin	Stimulate osteogensis both in vitro studies and subcutaneous injection animal model [13, 64–69]	Inhibits the osteoclastogenesis and osteoclastic activity [14–17, 70, 71]	No relationship was found after adjust for age, gender and hormone [11, 18–36]
Resistin	Stimulates proliferation and weakly promotes the osteoblasts maturation [37]	Strongly increases the number and activity of osteoclast [37]	Negative related with certain population [10, 24]
Visfatin	Stimulates human osteoblast proliferation, maturation, and mineralization [38, 39]	Inhibits the formation of osteoclast [40]	No relationship was found [24, 33, 41, 42]
Vaspin	Inhibits the apoptosis of osteoblast [43]	No paper published	No paper published
Chemerin	Negative effect by greatly promoting the adipogenesis of the MSCs [44]	No paper published	No paper published
Omentin-1	Inhibits the osteoblastic differentiation [45]	No paper published	Not clear, need more data [42, 72]