Clinical Study

Selective Determinants of Low Bone Mineral Mass in Adult Women with Anorexia Nervosa

Table 4

Relationship of BMD and variables measured (univariate regression analyses and multiple regression models constructed by backward stepwise).

AP spine BMDFemoral neck BMD
VariablesUnivariateMultivariateUnivariateMultivariate
Regres. coeff.
(95% CI)
Regres.coeff.
(95% CI)
Regres. coeff.
(95% CI)
Regres. coeff.
(95% CI)

Age (yrs)# 0.29
(−0.81; 1.39)
ns 1.24
(0.28; 2.19)
0.01 9%
Disease duration (yrs)°−0.01
(−0.02; −0.00)
0.03 7%−0.01
(−0.02; −0.00)
0.0110%
Duration of amenorrhea
(months)*
−0.03
(−0.06; −0.01)
0.0110%−0.03
(−0.05; −0.01)
0.01−0.03
(−0.05; −0.00)
0.02 8%
BMI (Kg/m2) 0.02
(0.00; 0.03)
0.02 9% 0.01
(−0.01; 0.02)
ns
IGF-I (µg/mL)° 0.01
(0.00; 0.02)
0.0111% 0.02
(0.01; 0.02)
0.00122%0.01 (0.01; 0.02)0.001
IGFBP-3 (mg/mL) 0.01
(−0.01; 0.04)
ns 0.03
(0.00; 0.05)
0.0216%
Parathyroid hormone# 0.11
(−0.14; 0.35)
ns 0.19
(−0.05; 0.44)
ns
25 OH-Vitamin D (nmol/l)° 0.00
(−0.01; 0.02)
ns−0.001
(−0.01; 0.01)
ns
Physical activity (h/week)° 0.03
(−0.00; 0.06)
ns 0.01
(−0.02; 0.04)
ns
Protein intake (g/kg of body
weight × d)°
−0.07
(−0.16; 0.01)
ns−0.04
(−0.11; 0.04)
ns
Calcium intake (mg/d)*−0.04
(−0.10; 0.02)
ns−0.02
(−0.07; 0.03)
ns
21%29%

Reciprocal root variable (1/square root).
°Square root transformed variable.
*Log transformed variable.