Clinical Study
Selective Determinants of Low Bone Mineral Mass in Adult Women with Anorexia Nervosa
Table 4
Relationship of BMD and variables measured (univariate regression analyses and multiple regression models constructed by backward stepwise).
| | AP spine BMD | Femoral neck BMD | Variables | Univariate | Multivariate | Univariate | Multivariate | | Regres. coeff. (95% CI) | | | Regres.coeff. (95% CI) | | | Regres. coeff. (95% CI) | | | Regres. coeff. (95% CI) | | |
| Age (yrs)# | 0.29 (−0.81; 1.39) | ns | | | | | 1.24 (0.28; 2.19) | 0.01 | 9% | | | | Disease duration (yrs)° | −0.01 (−0.02; −0.00) | 0.03 | 7% | | | | −0.01 (−0.02; −0.00) | 0.01 | 10% | | | | Duration of amenorrhea (months)* | −0.03 (−0.06; −0.01) | 0.01 | 10% | −0.03 (−0.05; −0.01) | 0.01 | | −0.03 (−0.05; −0.00) | 0.02 | 8% | | | | BMI (Kg/m2) | 0.02 (0.00; 0.03) | 0.02 | 9% | | | | 0.01 (−0.01; 0.02) | ns | | | | | IGF-I (µg/mL)° | 0.01 (0.00; 0.02) | 0.01 | 11% | | | | 0.02 (0.01; 0.02) | 0.001 | 22% | 0.01 (0.01; 0.02) | 0.001 | | IGFBP-3 (mg/mL) | 0.01 (−0.01; 0.04) | ns | | | | | 0.03 (0.00; 0.05) | 0.02 | 16% | | | | Parathyroid hormone# | 0.11 (−0.14; 0.35) | ns | | | | | 0.19 (−0.05; 0.44) | ns | | | | | 25 OH-Vitamin D (nmol/l)° | 0.00 (−0.01; 0.02) | ns | | | | | −0.001 (−0.01; 0.01) | ns | | | | | Physical activity (h/week)° | 0.03 (−0.00; 0.06) | ns | | | | | 0.01 (−0.02; 0.04) | ns | | | | | Protein intake (g/kg of body weight × d)° | −0.07 (−0.16; 0.01) | ns | | | | | −0.04 (−0.11; 0.04) | ns | | | | | Calcium intake (mg/d)* | −0.04 (−0.10; 0.02) | ns | | | | | −0.02 (−0.07; 0.03) | ns | | | | | | | | | | | 21% | | | | | | 29% |
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Reciprocal root variable (1/square root).
°Square root transformed variable.
*Log transformed variable.
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