The Changes in the Endothelial Function and Haemostatic and Inflammatory Parameters in Subclinical and Overt Hyperthyroidism

Table 2

Selected markers of inflammation and endothelial dysfunction in the patients with overt (OH) and subclinical hyperthyroidism (SH) and in the control group.

	OH (𝑛=56); median (C25–C75)	SH (𝑛=61); median (C25–C75)	Control (𝑛=39); median (C25–C75)	𝑃 value
IL-6 (ng/mL)	1.8 (1.1–2.9)	1.7 (1.1–3..8)	1.2 (0.7–1.8)	^∗𝑃<0.05, ^∗∗𝑃<0.05
IL-12 (pg/mL)	3.1 (1.7–5.7)	1.8 (0.65–4.6)	0.5 (0.5–1.4)	^∗𝑃<0.0001, ^∗∗𝑃<0.05, ^∗∗∗𝑃<0.05
IL-18 (pg/mL)	276.3 (186.0–368.5)	212.8 (161.0–300.2)	232.8 (181.1–257.8)	^∗𝑃<0.05, ^∗∗∗𝑃<0.05
CRP (ng/mL)	3.7 (3.1–5.4)	3.6 (2.7–4.7)	3.2 (2.7–4.3)	NS
Fibrinogen (mg/dL)	314.5 (253.5–374.0)	245.0 (172.0–303.0)	244.0 (185.0–325.0)	^∗𝑃<0.05, ^∗∗∗𝑃<0.01
PAI-1 (ng/mL)	54.6 (32.9–84.5)	59.3 (28.0–88.4)	31.5 (18.2–47.0)	^∗𝑃<0.001, ^∗∗𝑃<0.01
vWF (ng/mL)	129.3 (117.0–144.4)	111.8 (987–132.5)	94.2 (73.0–116.3)	^∗𝑃<0.0001,^∗∗∗𝑃<0.05
E-selectin (ng/mL)	45.0 (34.0–68.0)	52.0 (36.0–70.0)	58.0 (40.0–68.0)	NS
sICAM-1 (ng/mL)	351.0 (294.0–409.0)	316.0 (262.0–378.0)	314.0 (278.0–404.0)	NS
sVCAM-1 (ng/mL)	1129.2 (943.0–1580.5)	1107.0 (835.0–1380.0)	792.0 (607.0–1010.0)	^∗𝑃<0.0001, ^∗∗𝑃<0.001

Data are shown as medians with interquartile ranges.
Differences between groups were compared by the Kruskal-Wallis test.
*Differences between OH and control groups, **differences between SH and control groups, ***differences between OH and SH, NS: not significant.