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International Journal of Endocrinology
Volume 2014, Article ID 104318, 8 pages
http://dx.doi.org/10.1155/2014/104318
Research Article

Association between Lower Normal Free Thyroxine Concentrations and Obesity Phenotype in Healthy Euthyroid Subjects

1Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Republic of Korea
2The Catholic University of Korea Incheon St. Mary’s Hospital, 665 Bupyung-6-dong, Bupyung-gu, Incheon 403-720, Republic of Korea

Received 30 January 2014; Revised 29 March 2014; Accepted 29 March 2014; Published 28 April 2014

Academic Editor: Amelie Bonnefond

Copyright © 2014 Jeong Ah Shin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Andres, “Effect of obesity on total mortality,” International Journal of Obesity, vol. 4, no. 4, pp. 381–386, 1980. View at Google Scholar · View at Scopus
  2. N. B. Ruderman, S. H. Schneider, and P. Berchtold, “The “metabolically-obese,” normal-weight individual,” American Journal of Clinical Nutrition, vol. 34, no. 8, pp. 1617–1621, 1981. View at Google Scholar · View at Scopus
  3. J. Ärnlöv, E. Ingelsson, J. Sundström, and L. Lind, “Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men,” Circulation, vol. 121, no. 2, pp. 230–236, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. J. E. Silva, “The thermogenic effect of thyroid hormone and its clinical implications,” Annals of Internal Medicine, vol. 139, no. 3, pp. 205–213, 2003. View at Google Scholar · View at Scopus
  5. N. Rodondi, W. P. J. Den Elzen, D. C. Bauer et al., “Subclinical hypothyroidism and the risk of coronary heart disease and mortality,” Journal of the American Medical Association, vol. 304, no. 12, pp. 1365–1374, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Ruhla, M. O. Weickert, A. M. Arafat et al., “A high normal TSH is associated with the metabolic syndrome,” Clinical Endocrinology, vol. 72, no. 5, pp. 696–701, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. S. M. Boekholdt, S. M. Titan, W. M. Wiersinga et al., “Initial thyroid status and cardiovascular risk factors: the EPIC-Norfolk prospective population study,” Clinical Endocrinology, vol. 72, no. 3, pp. 404–410, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. H. T. Park, G. J. Cho, K. H. Ahn et al., “Thyroid stimulating hormone is associated with metabolic syndrome in euthyroid postmenopausal women,” Maturitas, vol. 62, no. 3, pp. 301–305, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. S.-Y. Lin, Y.-Y. Wang, P.-H. Liu, W.-A. Lai, and W. H.-H. Sheu, “Lower serum free thyroxine levels are associated with metabolic syndrome in a Chinese population,” Metabolism: Clinical and Experimental, vol. 54, no. 11, pp. 1524–1528, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Roos, S. J. L. Bakker, T. P. Links, R. O. B. Gans, and B. H. R. Wolffenbuttel, “Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 2, pp. 491–496, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Brochu, A. Tchernof, I. J. Dionne et al., “What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women?” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 3, pp. 1020–1025, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. A. D. Karelis, M. Faraj, J.-P. Bastard et al., “The metabolically healthy but obese individual presents a favorable inflammation profile,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 7, pp. 4145–4150, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Weiss, S. E. Taksali, S. Dufour et al., “The “Obese insulin-sensitive” adolescent: importance of adiponectin and lipid partitioning,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 6, pp. 3731–3737, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. M.-J. Shin, Y. J. Hyun, O. Y. Kim, J. Y. Kim, Y. Jang, and J. H. Lee, “Weight loss effect on inflammation and LDL oxidation in metabolically healthy but obese (MHO) individuals: low inflammation and LDL oxidation in MHO women,” International Journal of Obesity, vol. 30, no. 10, pp. 1529–1534, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. R. P. Wildman, P. Muntner, K. Reynolds et al., “The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999–2004),” Archives of Internal Medicine, vol. 168, no. 15, pp. 1617–1624, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. C. L. Jennings, E. V. Lambert, M. Collins, Y. Joffe, N. S. Levitt, and J. H. Goedecke, “Determinants of insulin-resistant phenotypes in normal-weight and obese black african women,” Obesity, vol. 16, no. 7, pp. 1602–1609, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Succurro, M. A. Marini, S. Frontoni et al., “Insulin secretion in metabolically obese, but normal weight, and in metabolically healthy but obese individuals,” Obesity, vol. 16, no. 8, pp. 1881–1886, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. C. A. Aguilar-Salinas, E. G. García, L. Robles et al., “High adiponectin concentrations are associated with the metabolically healthy obese phenotype,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 10, pp. 4075–4079, 2008. View at Publisher · View at Google Scholar
  19. D. H. St-Pierre, A. D. Karelis, L. Coderre et al., “Association of acylated and nonacylated ghrelin with insulin sensitivity in overweight and obese postmenopausal women,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 1, pp. 264–269, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. M. A. Marini, E. Succurro, S. Frontoni et al., “Metabolically healthy but obese women have an intermediate cardiovascular risk profile between healthy nonobese women and obese insulin-resistant women,” Diabetes Care, vol. 30, no. 8, pp. 2145–2147, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Ambrosi, B. Masserini, L. Iorio et al., “Relationship of thyroid function with body mass index and insulin-resistance in euthyroid obese subjects,” Journal of Endocrinological Investigation, vol. 33, no. 9, pp. 640–643, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. G. de Pergola, A. Ciampolillo, S. Paolotti, P. Trerotoli, and R. Giorgino, “Free triiodothyronine and thyroid stimulating hormone are directly associated with waist circumference, independently of insulin resistance, metabolic parameters and blood pressure in overweight and obese women,” Clinical Endocrinology, vol. 67, no. 2, pp. 265–269, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. A. E. Makepeace, A. P. Bremner, P. O'Leary et al., “Significant inverse relationship between serum free T4 concentration and body mass index in euthyroid subjects: differences between smokers and nonsmokers,” Clinical Endocrinology, vol. 69, no. 4, pp. 648–652, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. N. Knudsen, P. Laurberg, L. B. Rasmussen et al., “Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 7, pp. 4019–4024, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Nannipieri, F. Cecchetti, M. Anselmino et al., “Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight loss,” International Journal of Obesity, vol. 33, no. 9, pp. 1001–1006, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Reinehr, “Obesity and thyroid function,” Molecular and Cellular Endocrinology, vol. 316, no. 2, pp. 165–171, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Mueller, C. Schöfl, R. Dittrich et al., “Thyroid-stimulating hormone is associated with insulin resistance independently of body mass index and age in women with polycystic ovary syndrome,” Human Reproduction, vol. 24, no. 11, pp. 2924–2930, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. J. D. J. Garduño-Garcia, U. Alvirde-Garcia, G. López-Carrasco et al., “TSH and free thyroxine concentrations are associated with differing metabolic markers in euthyroid subjects,” European Journal of Endocrinology, vol. 163, no. 2, pp. 273–278, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Muscogiuri, G. Sorice, T. Mezza et al., “High-normal TSH values in obesity: is it insulin resistance or adipose tissue's guilt?” Obesity, vol. 21, pp. 101–106, 2012. View at Google Scholar
  30. G. Roef, B. Lapauw, S. Goemaere et al., “Body composition and metabolic parameters are associated with variation in thyroid hormone levels among euthyroid young men,” European Journal of Endocrinology, vol. 167, pp. 719–726, 2012. View at Publisher · View at Google Scholar
  31. E. S. Kim, J. Y. Shin, D. J. Lim et al., “Association between low serum free thyroxine concentrations and coronary artery calcification in healthy euthyroid subjects,” Thyroid, vol. 22, pp. 870–876, 2012. View at Publisher · View at Google Scholar
  32. G. Brenta, “Why can insulin resistance be a natural consequence of thyroid dysfunction?” Journal of Thyroid Research, vol. 2011, Article ID 152850, 9 pages, 2011. View at Publisher · View at Google Scholar
  33. P. Cettour-Rose, C. Theander-Carrillo, C. Asensio et al., “Hypothyroidism in rats decreases peripheral glucose utilisation, a defect partially corrected by central leptin infusion,” Diabetologia, vol. 48, no. 4, pp. 624–633, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Peppa, C. Koliaki, P. Nikolopoulos, and S. A. Raptis, “Skeletal muscle insulin resistance in endocrine disease,” Journal of Biomedicine and Biotechnology, vol. 2010, Article ID 527850, 13 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. L. A. Gavin, M. Moller, F. McMahon, R. Gulli, and R. R. Cavalieri, “Carbohydrate reactivation of thyroxine 5′-deiodinase (type II) in cultured mouse neuroblastoma cells is dependent upon new protein synthesis,” Endocrinology, vol. 124, no. 2, pp. 635–641, 1989. View at Google Scholar · View at Scopus
  36. J. Després, “What is “metabolically healthy obesity”?: from epidemiology to pathophysiological insights,” Journal of Clinical Endocrinology and Metabolism, vol. 97, pp. 2283–2285, 2012. View at Publisher · View at Google Scholar
  37. B. O. Asvold, T. Bjøro, T. I. Nilsen, and L. J. Vatten, “Tobacco smoking and thyroid function: a population-based study,” Archives of Internal Medicine, vol. 167, no. 13, pp. 1428–1432, 2007. View at Publisher · View at Google Scholar
  38. L. H. Canani, C. Capp, J. M. Dora et al., “The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 6, pp. 3472–3478, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Marsili, C. Aguayo-Mazzucato, T. Chen et al., “Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity,” PLoS ONE, vol. 6, no. 6, Article ID e20832, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. T. Ittermann, R. Haring, H. Wallaschofski et al., “Inverse association between serum free thyroxine levels and hepatic steatosis: results from the Study of Health in Pomerania,” Thyroid, vol. 22, no. 6, pp. 568–574, 2012. View at Publisher · View at Google Scholar
  41. E. Murphy, C. C. Glüer, D. M. Reid et al., “Thyroid function within the upper normal range is associated with reduced bone mineral density and an increased risk of nonvertebral fractures in healthy euthyroid postmenopausal women,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 7, pp. 3173–3181, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. B. B. Yeap, H. Alfonso, S. A. P. Chubb et al., “Higher free thyroxine levels are associated with frailty in older men: the Health in Men study,” Clinical Endocrinology, vol. 76, no. 5, pp. 741–748, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. M. D. Gammage, J. V. Parle, R. L. Holder et al., “Association between serum free thyroxine concentration and atrial fibrillation,” Archives of Internal Medicine, vol. 167, no. 9, pp. 928–934, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. G. Brent, “Mechanisms of thyroid hormone action,” The Journal of Clinical Investigation, vol. 122, no. 9, pp. 3035–3043, 2012. View at Publisher · View at Google Scholar
  45. R. Hoermann, W. Eckl, C. Hoermann, and R. Larisch, “Complex relationship between free thyroxine and TSH in the regulation of thyroid function,” European Journal of Endocrinology, vol. 162, no. 6, pp. 1123–1129, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. R. Hoermann, J. E. M. Midgley, R. Larisch, and J. Dietrich, “Is pituitary TSH an adequate measure of thyroid hormone-controlled homoeostasis during thyroxine treatment?” European Journal of Endocrinology, vol. 168, pp. 271–280, 2013. View at Publisher · View at Google Scholar
  47. D. R. Matthews, J. P. Hosker, and A. S. Rudenski, “Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man,” Diabetologia, vol. 28, no. 7, pp. 412–419, 1985. View at Google Scholar · View at Scopus