Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats

Table 2

The survival time values for normothermic diabetic rats (NTDR) treated with vehicle (NTDR + V), heatstroke-diabetic rats treated with vehicle (HSDR + V), and heatstroke-diabetic rats treated with honokiol (HSDR + H).

Treatment groups	Survival time (min)
(1) NTDR + V	480±3 (8)
(2) HSDR + V	79±3 (8)*
(3) HSDR + H (0.5 mg/mL/kg)	114±5 (8)^+
(4) HSDR + H (1.5 mg/mL/kg)	186±9 (8)^+
(5) HSDR + H (5.0 mg/mL/kg)	273±15 (8)^+

All heatstroke rats which had heat exposure (43°C) were withdrawn exactly at 60 minutes and then allowed to recover at room temperature (26°C). Data are mean ± SD, followed by number of animals in parentheses. Normothermic controls (NTDR + V) were killed about 480 minutes after experiment (or at the experimental end) with the urethane overdose.
 ^∗𝑃<0.01, in comparison with Group 1.
 ⁺𝑃<0.05, in comparison with Group 2 (Dunn’s test followed by Kruskal-Wallis test). Vehicle solution or melatonin was adopted 60 minutes before the start of heat stress.