CHADS₂ Scores in the Prediction of Major Adverse Cardiovascular Events in Patients with Cushing’s Syndrome

Table 3

Hazard ratios of individual CHADS₂ score for MACEs in patients with Cushing’s syndrome (𝑛=551).

	Model A*			Model B**
	Adjusted HR	95% CI	𝑃 value	Adjusted HR	95% CI	𝑃 value
CHADS2 score	1.63	1.29–2.06	<0.001
0				1
1				1.95	0.63–6.03	0.246
2				2.77	0.90–8.48	0.074
≧3				7.16	2.31–22.15	0.001
Gender
Male	1			1
Female	0.50	0.28–0.90	0.022	0.45	0.25–0.81	0.009
Age	1.03	1.00–1.05	0.006	1.02	1.00–1.05	0.026
Hyperlipidemia	0.50	0.23–1.08	0.078	0.55	0.26–1.15	0.114
Chronic kidney disease	1.26	0.52–3.03	0.599	1.35	0.58–3.14	0.484
Coronary artery disease	1.44	0.67–3.09	0.343	1.59	0.76–3.32	0.216
Atrial fibrillation	1.17	0.24–5.53	0.843	1.17	0.25–5.47	0.839
Socioeconomic status
Low	1			1
Moderate	1.69	0.90–3.17	0.099	1.57	0.84–2.93	0.156
High	1.22	0.32–4.54	0.764	1.17	0.31–4.32	0.812

Adjusted HR: adjusted hazard ratio; 95% CI: 95% confidence interval.
*Model A: CHADS₂ score as continuous variable.
**Model B: CHADS₂ score as ordinal variable.