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International Journal of Endocrinology
Volume 2014, Article ID 143763, 10 pages
Review Article

Testosterone Deficiency, Cardiac Health, and Older Men

1Heartlands Hospital, Bordesley Green East, Birmingham, B9 5SS, UK
2IDOP, University of Bedfordshire, Putteridge Bury Campus, Luton, Bedfordshire LU2 8LE, UK
3The Prostate Centre, 32 Wimpole Street, London W1G 8GT, UK
4The Luton & Dunstable Hospital, Lewsey Road, Luton, Bedfordshire LU4 0DZ, UK

Received 26 November 2013; Revised 12 January 2014; Accepted 5 February 2014; Published 10 April 2014

Academic Editor: Antonio Aversa

Copyright © 2014 G. Hackett et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Low levels of testosterone are manifested by erectile dysfunction, reduced sexual desire, and loss of morning erections with increasing numbers of men are being diagnosed and require treatment. The prevalence rates of testosterone deficiency vary according to different studies but may be as high as 40% in populations of patients with type 2 diabetes. There is increasing evidence that testosterone deficiency is associated with increased cardiovascular and all-cause mortality. Screening for low testosterone is recommended in a number of high risk groups including those with type 2 diabetes and metabolic syndrome. There are recent data to suggest that testosterone replacement therapy may reduce cardiovascular mortality as well as improving multiple surrogate markers for cardiovascular events. Specific clinical trials of testosterone replacement therapy are needed in selected populations but in the meantime we must treat patients based on the best current evidence.