Two Novel CYP11B1 Gene Mutations in Patients from Two Croatian Families with 11β-Hydroxylase Deficiency

Figure 4

p.R141 is conserved in mammalian CYP11B1 protein. The GenBank protein sequences used for the alignment were NP_000488.3 (Homo sapiens, Human), NP_001180667.1 (Macaca mulatta, Rhesus Monkey), XP_002759236.1 (Callithrix jacchus, White-Tufted-Ear Marmoset), NP_777063.2 (Bos taurus, Cattle), NP_001068568.1 (Ovis aries, Sheep), NP_001166410.1 (Cavia porcellus, Guinea Pig), NP_001028401.2 (Mus musculus, Mouse), and NP_036669.3 (Rattus norvegicus, Rat). p.R141 is in bold letter. Fully (asterisk), strongly (colon), and weakly (period) conserved residues are indicated.