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International Journal of Endocrinology
Volume 2014 (2014), Article ID 191247, 8 pages
http://dx.doi.org/10.1155/2014/191247
Research Article

Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled Study

1Endocrinology Division, University Hospital “Dr. José E. González”, School of Medicine, Autonomous University of Nuevo León, Francisco I. Madero and Gonzalitos s/n, 64460 Monterrey, NL, Mexico
2Obstetrics and Gynecology Department, University Hospital “Dr. José E. González”, School of Medicine, Autonomous University of Nuevo León, Francisco I. Madero and Gonzalitos s/n, 64460 Monterrey, NL, Mexico
3Clinical Research Unit, University Hospital “Dr. José E. González”, School of Medicine, Autonomous University of Nuevo León, Francisco I. Madero and Gonzalitos s/n, 64460 Monterrey, NL, Mexico

Received 4 September 2014; Revised 2 November 2014; Accepted 3 November 2014; Published 23 November 2014

Academic Editor: Mario Maggi

Copyright © 2014 René Rodríguez-Gutiérrez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Although the association between human chorionic gonadotropin (hCG) and hyperandrogenism was identified more than 40 years ago, relevant questions remain unanswered. Design and Methods. We conducted a prospective, longitudinal, and controlled study in 23 women with a diagnosis of a complete hydatidiform mole (HM). Results. All participants completed the study. Before HM evacuation mean hCG was markedly higher in the cases than in the control group (). Free testosterone (T) and dehydroepiandrosterone sulfate (DHEA-S) were found to be higher in the cases (2.78 ± 1.24 pg/mL and 231.50 ± 127.20 μ/dL) when compared to the control group (1.50 ± 0.75 pg/mL and 133.59 ± 60.69 μ/dL) ( and 0.001), respectively. There was a strong correlation between hCG and free T/total T/DHEA-S concentrations (; , ;  , and ;  ), respectively. In the cases group 48 hours after HM evacuation, hCG levels were found to be significantly lower when compared to initial levels () and free T and DHEA-S declined significantly ( and 0.009). Conclusion. Before uterus evacuation, hCG, free T, and DHEA-S levels were significantly higher when compared with controls finding a strong correlation between hCG and free T/DHEA-S levels. Forty-eight hours after HM treatment hCG levels declined and the difference was lost. A novel finding of our study is that in cases, besides free T, DHEA-S was also found to be significantly higher and both the ovaries and adrenal glands appear to be the sites of this androgen overproduction.