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International Journal of Endocrinology
Volume 2014 (2014), Article ID 234014, 24 pages
http://dx.doi.org/10.1155/2014/234014
Review Article

Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine Interactions

1Department of Biology, Bishop’s University, Sherbrooke, QC, Canada J1M 1Z7
2Centre de Recherche Clinique Etienne-Le Bel, Université de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4
3Department of Physiology, University of Alberta, Edmonton, AB, Canada T6G 2R3

Received 23 October 2014; Accepted 26 November 2014; Published 15 December 2014

Academic Editor: Maria L. Dufau

Copyright © 2014 Kerry L. Hull and Steve Harvey. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. L. Hull and S. Harvey, “Growth hormone: a reproductive endocrine-paracrine regulator?” Reviews of Reproduction, vol. 5, no. 3, pp. 175–182, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. K. L. Hull and S. Harvey, “Growth hormone: roles in male reproduction,” Endocrine, vol. 13, no. 3, pp. 243–250, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. K. L. Hull and S. Harvey, “Growth hormone: roles in female reproduction,” Journal of Endocrinology, vol. 168, no. 1, pp. 1–23, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. K. L. Hull and S. Harvey, “GH as a co-gonadotropin: the relevance of correlative changes in GH secretion and reproductive state,” Journal of Endocrinology, vol. 172, no. 1, pp. 1–19, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. P. A. Kelly, A. Bachelot, C. Kedzia et al., “The role of prolactin and growth hormone in mammary gland development,” Molecular and Cellular Endocrinology, vol. 197, no. 1-2, pp. 127–131, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. E. Van Garderen and J. A. Schalken, “Morphogenic and tumorigenic potentials of the mammary growth hormone/growth hormone receptor system,” Molecular and Cellular Endocrinology, vol. 197, no. 1-2, pp. 153–165, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. J. F. Trott, B. K. Vonderhaar, and R. C. Hovey, “Historical perspectives of prolactin and growth Hormone as mammogens, lactogens and galactagogues: agog for the future!,” Journal of Mammary Gland Biology and Neoplasia, vol. 13, no. 1, pp. 3–11, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. D. L. Kleinberg, T. L. Wood, P. A. Furth, and A. V. Lee, “Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions,” Endocrine Reviews, vol. 30, no. 1, pp. 51–74, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. J. K. Perry, K. M. Mohankumar, B. S. Emerald, H. C. Mertani, and P. E. Lobie, “The contribution of growth hormone to mammary neoplasia,” Journal of Mammary Gland Biology and Neoplasia, vol. 13, no. 1, pp. 131–145, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. S. E. Brunet-Dunand, C. Vouyovitch, S. Araneda et al., “Autocrine human growth hormone promotes tumor angiogenesis in mammary carcinoma,” Endocrinology, vol. 150, no. 3, pp. 1341–1352, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. S. A. Kaplan and P. Cohen, “Review: the somatomedin hypothesis 2007: 50 years later,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 12, pp. 4529–4535, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. D. le Roith, C. Bondy, S. Yakar, J. L. Liu, and A. Butler, “The somatomedin hypothesis: 2001,” Endocrine Reviews, vol. 22, no. 1, pp. 53–74, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Cailleau, S. Vermeire, and G. Verhoeven, “Independent control of the production of insulin-like growth factor I and its binding protein by cultured testicular cells,” Molecular and Cellular Endocrinology, vol. 69, no. 1, pp. 79–89, 1990. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Xu, D. Sun, J. Jiang et al., “The role of prolactin receptor in GH signaling in breast cancer cells,” Molecular Endocrinology, vol. 27, no. 2, pp. 266–279, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Gan, A. Buckels, Y. Liu et al., “Human GH receptor-IGF-1 receptor interaction: implications for GH signaling,” Molecular Endocrinology, vol. 28, no. 11, pp. 1841–1854, 2014. View at Publisher · View at Google Scholar
  16. A. Zerrad-Saadi, M. Lambert-Blot, C. Mitchell et al., “GH receptor plays a major role in liver regeneration through the control of EGFR and ERK1/2 activation,” Endocrinology, vol. 152, no. 7, pp. 2731–2741, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. X. Li, Y. Huang, J. Jiang, and S. J. Frank, “Synergy in ERK activation by cytokine receptors and tyrosine kinase growth factor receptors,” Cellular Signalling, vol. 23, no. 2, pp. 417–424, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. V. Chesnokova, C. Zhou, A. Ben-Shlomo et al., “Growth hormone is a cellular senescence target in pituitary and nonpituitary cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 35, pp. E3331–E3339, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. M. P. Wajnrajch, “Physiological and pathological growth hormone secretion,” Journal of Pediatric Endocrinology and Metabolism, vol. 18, no. 4, pp. 325–338, 2005. View at Google Scholar · View at Scopus
  20. M. J. Van Den Eijnden and G. J. Strous, “Autocrine growth hormone: effects on growth hormone receptor trafficking and signaling,” Molecular Endocrinology, vol. 21, no. 11, pp. 2832–2846, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. X. Q. Xu, B. S. Emerald, E. L. K. Goh et al., “Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinoma,” Journal of Biological Chemistry, vol. 280, no. 25, pp. 23987–24003, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Harvey, “Extrapituitary growth hormone,” Endocrine, vol. 38, no. 3, pp. 335–359, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. O. Shevah and Z. Laron, “Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: a preliminary report,” Growth Hormone & IGF Research, vol. 17, no. 1, pp. 54–57, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Ikeno, R. T. Bronson, G. B. Hubbard, S. Lee, and A. Bartke, “Delayed occurrence of fatal neoplastic diseases in Ames dwarf mice: correlation to extended longevity,” The Journals of Gerontology A: Biological Sciences and Medical Sciences, vol. 58, no. 4, pp. 291–296, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Melmed, “Medical progress: acromegaly,” The New England Journal of Medicine, vol. 355, no. 24, pp. 2558–2573, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. A. G. Renehan and B. M. Brennan, “Acromegaly, growth hormone and cancer risk,” Best Practice and Research: Clinical Endocrinology and Metabolism, vol. 22, no. 4, pp. 639–657, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. M. L. Hartman, R. Xu, B. J. Crowe et al., “Prospective safety surveillance of GH-deficient adults: comparison of GH-treated vs untreated patients,” The Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 3, pp. 980–988, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. J. K. Perry, B. S. Emerald, H. C. Mertani, and P. E. Lobie, “The oncogenic potential of growth hormone,” Growth Hormone and IGF Research, vol. 16, no. 5-6, pp. 277–289, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Chhabra, M. J. Waters, and A. J. Brooks, “Role of the growth hormone-IGF-1 axis in cancer,” Expert Review of Endocrinology and Metabolism, vol. 6, no. 1, pp. 71–84, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. K. Hull and S. Harvey, “Growth hormone and cancer,” in Molecular and Cellular Pathology of Cancer: Progression and Prognosis, G. B. Sherbet, Ed., Research Signpost, Kerala, India, 2005. View at Google Scholar
  31. A. V. Dreval, I. V. Trigolosova, I. V. Misnikova et al., “Prevalence of diabetes mellitus in patients with acromegaly,” Endocrine Connections, vol. 3, no. 2, pp. 93–98, 2014. View at Publisher · View at Google Scholar
  32. S. Fieffe, I. Morange, P. Petrossians et al., “Diabetes in acromegaly, prevalence, risk factors, and evolution: data from the French Acromegaly Registry,” European Journal of Endocrinology, vol. 164, no. 6, pp. 877–884, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. N. Møller and J. O. L. Jørgensen, “Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects,” Endocrine Reviews, vol. 30, no. 2, pp. 152–177, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. G. G. Kaiser, S. Kölle, G. Boie, F. Sinowatz, G. A. Palma, and R. H. Alberio, “In vivo effect of growth hormone on the expression of connexin-43 in bovine ovarian follicles,” Molecular Reproduction and Development, vol. 73, no. 5, pp. 600–606, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. E. Reiter, P. Bonnet, B. Sente et al., “Growth hormone and prolactin stimulate androgen receptor, insulin-like growth factor-I (IGF-I) and IGF-I receptor levels in the prostate of immature rats,” Molecular and Cellular Endocrinology, vol. 88, no. 1–3, pp. 77–87, 1992. View at Publisher · View at Google Scholar · View at Scopus
  36. E. Gutiérrez-pascual, A. J. Martínez-fuentes, L. Pinilla, M. Tena-Sempere, M. M. Malagón, and J. P. Castaño, “Direct pituitary effects of kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinising hormone and growth hormone secretion,” Journal of Neuroendocrinology, vol. 19, no. 7, pp. 521–530, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. D. Vaudry, B. J. Gonzalez, M. Basille, L. Yon, A. Fournier, and H. Vaudry, “Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions,” Pharmacological Reviews, vol. 52, no. 2, pp. 269–324, 2000. View at Google Scholar · View at Scopus
  38. G. V. Childs, “Growth hormone cells as co-gonadotropes: partners in the regulation of the reproductive system,” Trends in Endocrinology and Metabolism, vol. 11, no. 5, pp. 168–175, 2000. View at Publisher · View at Google Scholar · View at Scopus
  39. A. V. Sirotkin, “Control of reproductive processes by growth hormone: extra- and intracellular mechanisms,” Veterinary Journal, vol. 170, no. 3, pp. 307–317, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. J. D. Veldhuis, “Neuroendocrine facets of human puberty,” Neurobiology of Aging, vol. 24, no. 1, pp. S93–S122, 2003. View at Publisher · View at Google Scholar · View at Scopus
  41. J. S. Rocha, M. S. Bonkowski, L. R. de França, and A. Bartke, “Effects of mild calorie restriction on reproduction, plasma parameters and hepatic gene expression in mice with altered GH/IGF-I axis,” Mechanisms of Ageing and Development, vol. 128, no. 4, pp. 317–331, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. V. Chandrashekar, D. Zaczek, and A. Bartke, “The consequences of altered somatotropic system on reproduction,” Biology of Reproduction, vol. 71, no. 1, pp. 17–27, 2004. View at Publisher · View at Google Scholar · View at Scopus
  43. A. Bartke, L. Y. Sun, and V. Longo, “Somatotropic signaling: trade-offs between growth, reproductive development, and longevity,” Physiological Reviews, vol. 93, no. 2, pp. 571–598, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. D. Zaczek, J. Hammond, L. Suen et al., “Impact of growth hormone resistance on female reproductive function: new insights from growth hormone receptor knockout mice,” Biology of Reproduction, vol. 67, no. 4, pp. 1115–1124, 2002. View at Publisher · View at Google Scholar · View at Scopus
  45. M. Cecim, J. Kerr, and A. Bartke, “Effects of bovine growth hormone (bGH) transgene expression or bGH treatment on reproductive functions in female mice,” Biology of Reproduction, vol. 52, no. 5, pp. 1144–1148, 1995. View at Publisher · View at Google Scholar · View at Scopus
  46. M. F. Messina, T. Arrigoi, M. Valenzisei et al., “Long-term auxological and pubertal outcome of patients with hereditary insulin-like growth factor-I deficiency (Laron and growth hormone-gene deletion syndrome) treated with recombinant human insulin-like growth factor-I,” Journal of Endocrinological Investigation, vol. 34, no. 4, pp. 292–295, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. M. Menezes, R. Salvatori, C. R. P. Oliveira et al., “Climacteric in untreated isolated growth hormone deficiency,” Menopause, vol. 15, no. 4, pp. 743–747, 2008. View at Publisher · View at Google Scholar · View at Scopus
  48. M. E. Wilson, K. Chikazawa, J. Fisher, D. Mook, and K. G. Gould, “Reduced growth hormone secretion prolongs puberty but does not delay the developmental increase in luteinizing hormone in the absence of gonadal negative feedback,” Biology of Reproduction, vol. 71, no. 2, pp. 588–597, 2004. View at Publisher · View at Google Scholar · View at Scopus
  49. A.-K. Albin, C. Ankarberg-Lindgren, T. Tuvemo, B. Jonsson, K. Albertsson-Wikland, and E. M. Ritzén, “Does growth hormone treatment influence pubertal development in short children?” Hormone Research in Paediatrics, vol. 76, no. 4, pp. 262–272, 2011. View at Publisher · View at Google Scholar · View at Scopus
  50. A. Bartke, “Role of growth hormone and prolactin in the control of reproduction: what are we learning from transgenic and knock-out animals?” Steroids, vol. 64, no. 9, pp. 598–604, 1999. View at Publisher · View at Google Scholar · View at Scopus
  51. F. I. Sharara and L. C. Giudice, “Role of growth hormone in ovarian physiology and onset of puberty,” Journal of the Society for Gynecologic Investigation, vol. 4, no. 1, pp. 2–7, 1997. View at Publisher · View at Google Scholar · View at Scopus
  52. V. Chandrashekar, A. Bartke, C. A. Awoniyi et al., “Testicular endocrine function in GH receptor gene disrupted mice,” Endocrinology, vol. 142, no. 8, pp. 3443–3450, 2001. View at Publisher · View at Google Scholar · View at Scopus
  53. M. Kanzaki and P. L. Morris, “Growth hormone regulates steroidogenic acute regulatory protein expression and steroidogenesis in Leydig cell progenitors,” Endocrinology, vol. 140, no. 4, pp. 1681–1686, 1999. View at Google Scholar · View at Scopus
  54. M. M. Ilondo, M. Vanderschueren-Lodeweyckx, R. Vlietinck et al., “Plasma androgens in children and adolescents. Part II: longitudinal study in patients with hypopituitarism,” Hormone Research, vol. 16, no. 2, pp. 78–95, 1982. View at Publisher · View at Google Scholar · View at Scopus
  55. A. Christoforidis, I. Maniadaki, and R. Stanhope, “Growth hormone/insulin-like growth factor-1 axis during puberty,” Pediatric Endocrinology Reviews, vol. 3, no. 1, pp. 5–10, 2005. View at Google Scholar · View at Scopus
  56. M. M. Grumbach, “Estrogen, bone, growth and sex: a sea change in conventional wisdom,” Journal of Pediatric Endocrinology and Metabolism, vol. 13, no. 6, pp. 1439–1455, 2000. View at Google Scholar · View at Scopus
  57. A. D. Rogol, “Sex steroids, growth hormone, leptin and the pubertal growth spurt,” Endocrine Development, vol. 17, pp. 77–85, 2010. View at Publisher · View at Google Scholar · View at Scopus
  58. V. Chandrashekar, A. Bartke, K. T. Coschigano, and J. J. Kopchick, “Pituitary and testicular function in growth hormone receptor gene knockout mice,” Endocrinology, vol. 140, no. 3, pp. 1082–1088, 1999. View at Google Scholar · View at Scopus
  59. A. P. Nguyen, A. Chandorkar, and C. Gupta, “The role of growth hormone in fetal mouse reproductive tract differentiation,” Endocrinology, vol. 137, no. 9, pp. 3659–3666, 1996. View at Publisher · View at Google Scholar · View at Scopus
  60. Z. Laron and B. Klinger, “Effect of insulin-like growth factor-I treatment on serum androgens and testicular and penile size in males with Laron syndrome (primary growth hormone resistance),” European Journal of Endocrinology, vol. 138, no. 2, pp. 176–180, 1998. View at Publisher · View at Google Scholar · View at Scopus
  61. A. C. Lindgren, P. Chatelain, A. Lindberg et al., “Normal progression of testicular size in boys with idiopathic short stature and isolated growth hormone deficiency treated with growth hormone: experience from the KIGS,” Hormone Research, vol. 58, no. 2, pp. 83–87, 2002. View at Publisher · View at Google Scholar · View at Scopus
  62. I. Sjögren, M. Jönsson, A. Madej, H. E. Johansson, and L. Plöen, “Effects of very high doses of human growth hormone (hGH) on the male reproductive system in the dog,” Andrologia, vol. 30, no. 1, pp. 37–42, 1998. View at Google Scholar · View at Scopus
  63. I. Sjögren, S. Ekvärn, U. Zühlke et al., “Lack of effects of recombinant human GH on spermatogenesis in the adult cynomolgus monkey (Macaca fascicularis),” European Journal of Endocrinology, vol. 140, no. 4, pp. 350–357, 1999. View at Publisher · View at Google Scholar · View at Scopus
  64. M. S. Singh and K. P. Joy, “Effects of ovine LH, GH and prolactin, and testosterone on serum testosterone and estradiol-17β levels, and seminal vesicle and testicular activity in the catfish Clarias batrachus (L.),” Indian Journal of Experimental Biology, vol. 39, no. 1, pp. 52–56, 2001. View at Google Scholar · View at Scopus
  65. M. F. Hess and J. F. Roser, “A comparison of the effects of equine luteinizing hormone (eLH), equine growth hormone (eGH) and human recombinant insulin-like growth factor (hrIGF-I) on steroid production in cultured equine Leydig cells during sexual maturation,” Animal Reproduction Science, vol. 89, no. 1–4, pp. 7–19, 2005. View at Publisher · View at Google Scholar · View at Scopus
  66. C. Carani, A. R. M. Granata, M. De Rosa et al., “The effect of chronic treatment with GH on gonadal function in men with isolated GH deficiency,” European Journal of Endocrinology, vol. 140, no. 3, pp. 224–230, 1999. View at Publisher · View at Google Scholar · View at Scopus
  67. R. Balducci, V. Toscano, A. Mangiantini, P. Bianchi, R. Guglielmi, and B. Boscherini, “The effect of growth hormone administration on testicular response during gonadotropin therapy in subjects with combined gonadotropin and growth hormone deficiencies,” Acta Endocrinologica, vol. 128, no. 1, pp. 19–23, 1993. View at Google Scholar · View at Scopus
  68. D. R. Deaver and K. A. Bryan, “Effects of exogenous somatotropin (ST) on gonadal function in ruminants and swine,” Domestic Animal Endocrinology, vol. 17, no. 2-3, pp. 287–297, 1999. View at Publisher · View at Google Scholar · View at Scopus
  69. J. Oscarsson, G. Lindstedt, P.-A. Lundberg, and S. Edén, “Continuous subcutaneous infusion of low dose growth hormone decreases serum sex-hormone binding globulin and testosterone concentrations in moderately obese middle-aged men,” Clinical Endocrinology, vol. 44, no. 1, pp. 23–29, 1996. View at Publisher · View at Google Scholar · View at Scopus
  70. C. Giavoli, E. Ferrante, F. Ermetici et al., “Effect of recombinant hGH (rhGH) replacement on gonadal function in male patients with organic adult-onset GH deficiency,” Clinical Endocrinology, vol. 65, no. 6, pp. 717–721, 2006. View at Publisher · View at Google Scholar · View at Scopus
  71. M. Andreassen, J. Frystyk, J. Faber, L. Ø. Kristensen, and A. Juul, “Growth hormone (GH) activity is associated with increased serum oestradiol and reduced Anti-Müllerian Hormone in healthy male volunteers treated with GH and a GH antagonist,” Andrology, vol. 1, no. 4, pp. 595–601, 2013. View at Publisher · View at Google Scholar · View at Scopus
  72. F. Le Gac and M. Loir, “Control of testis function in fish: in vitro studies of gonadotropic regulation in the trout,” Reproduction Nutrition Developpement, vol. 28, pp. 1031–1046, 1988. View at Publisher · View at Google Scholar · View at Scopus
  73. F. Bex, A. Bartke, B. D. Goldman, and S. Dalterio, “Prolactin, growth hormone, luteinizing hormone receptors, and seasonal changes in testicular activity in the golden hamster,” Endocrinology, vol. 103, no. 6, pp. 2069–2080, 1978. View at Publisher · View at Google Scholar · View at Scopus
  74. P. G. Chatelain, P. Sanchez, and J. M. Saez, “Growth hormone and insulin-like growth factor I treatment increase testicular luteinizing hormone receptors and steroidogenic responsiveness of growth hormone deficient dwarf mice,” Endocrinology, vol. 128, no. 4, pp. 1857–1862, 1991. View at Publisher · View at Google Scholar · View at Scopus
  75. M. Gafny, A. Silbergeld, B. Klinger, M. Wasserman, and Z. Laron, “Comparative effects of GH, IGF-I and insulin on serum sex hormone binding globulin,” Clinical Endocrinology, vol. 41, no. 2, pp. 169–175, 1994. View at Publisher · View at Google Scholar · View at Scopus
  76. A. Juul, A.-M. Andersson, S. A. Pedersen et al., “Effects of growth hormone replacement therapy on IGF-related parameters and on the pituitary-gonadal axis in GH-deficient males. A double-blind, placebo-controlled crossover study,” Hormone Research, vol. 49, no. 6, pp. 269–278, 1998. View at Publisher · View at Google Scholar · View at Scopus
  77. A. Belgorosky, A. Martinez, H. Domene, J. J. Heinrich, C. Bergada, and M. A. Rivarola, “High serum sex hormone-binding globulin (SHBG) and low serum non-SHBG-bound testosterone in boys with idiopathic hypopituitarism: effect of recombinant human growth hormone treatment,” The Journal of Clinical Endocrinology and Metabolism, vol. 65, no. 6, pp. 1107–1111, 1987. View at Publisher · View at Google Scholar · View at Scopus
  78. B. T. Rudd, P. H. Rayner, and P. H. Thomas, “Observations on the role of GH/IGF-1 and sex hormone binding globulin (SHBG) in the pubertal development of growth hormone deficient (GHD) children,” Acta Endocrinologica Supplementum, vol. 279, pp. 164–169, 1986. View at Google Scholar
  79. B. Edén Engström, P. Burman, A. G. Johansson, L. Wide, and F. A. Karlsson, “Effects of short-term administration of growth hormone in healthy young men, women, and women taking oral contraceptives,” Journal of Internal Medicine, vol. 247, no. 5, pp. 570–578, 2000. View at Publisher · View at Google Scholar · View at Scopus
  80. D. J. Handelsman, J. A. Spaliviero, C. D. Scott, and R. C. Baxter, “Identification of insulin-like growth factor-I and its receptors in the rat testis,” Acta Endocrinologica, vol. 109, no. 4, pp. 543–549, 1985. View at Google Scholar · View at Scopus
  81. E. Colón, K. V. Svechnikov, C. Carlsson-Skwirut, P. Bang, and O. Soder, “Stimulation of steroidogenesis in immature rat leydig cells evoked by interleukin-1α is potentiated by growth hormone and insulin-like growth factors,” Endocrinology, vol. 146, no. 1, pp. 221–230, 2005. View at Publisher · View at Google Scholar · View at Scopus
  82. D. H. Ramdhan, Y. Ito, Y. Yanagiba et al., “Nanoparticle-rich diesel exhaust may disrupt testosterone biosynthesis and metabolism via growth hormone,” Toxicology Letters, vol. 191, no. 2-3, pp. 103–108, 2009. View at Publisher · View at Google Scholar · View at Scopus
  83. K. Ohyama, N. Iwatani, Y. Nakagomi et al., “Growth hormone advances spermatogenesis in premature rats treated with gonadotropin-releasing hormone agonist,” Endocrine Journal, vol. 46, no. 4, pp. 555–562, 1999. View at Publisher · View at Google Scholar · View at Scopus
  84. K. Satoh, K. Ohyama, Y. Nakagomi et al., “Effects of growth hormone on testicular dysfunction induced by cyclophosphamide (CP) in GH-deficient rats,” Endocrine Journal, vol. 49, no. 6, pp. 611–619, 2002. View at Publisher · View at Google Scholar · View at Scopus
  85. H. S. Nouri, Y. Azarmi, and M. Movahedin, “Effect of growth hormone on testicular dysfunction induced by methotrexate in rats,” Andrologia, vol. 41, no. 2, pp. 105–110, 2009. View at Publisher · View at Google Scholar · View at Scopus
  86. M. A. Figueiredo, R. V. Fernandes, A. L. Studzinski et al., “GH overexpression decreases spermatic parameters and reproductive success in two-years-old transgenic zebrafish males,” Animal Reproduction Science, vol. 139, no. 1–4, pp. 162–167, 2013. View at Publisher · View at Google Scholar · View at Scopus
  87. M. H. Vickers, P. J. Casey, Z. J. Champion, C. G. Gravance, and B. H. Breier, “IGF-I treatment increases motility and improves morphology of immature spermatozoa in the GH-deficient dwarf (dw/dw) rat,” Growth Hormone and IGF Research, vol. 9, no. 4, pp. 236–240, 1999. View at Publisher · View at Google Scholar · View at Scopus
  88. Z. J. Champion, M. H. Vickers, C. G. Gravance, B. H. Breier, and P. J. Casey, “Growth hormone or insulin-like growth factor-I extends longevity of equine spermatozoa in vitro,” Theriogenology, vol. 57, no. 7, pp. 1793–1800, 2002. View at Publisher · View at Google Scholar · View at Scopus
  89. A. Pal, A. K. Chakravarty, and P. N. Chatterjee, “Polymorphism of growth hormone gene and its association with seminal and sexual behavioral traits in crossbred cattle,” Theriogenology, vol. 81, no. 3, pp. 474–480, 2014. View at Publisher · View at Google Scholar · View at Scopus
  90. C. Miura, Y. Shimizu, M. Uehara, Y. Ozaki, G. Young, and T. Miura, “Gh is produced by the testis of Japanese eel and stimulates proliferation of spermatogonia,” Reproduction, vol. 142, no. 6, pp. 869–877, 2011. View at Publisher · View at Google Scholar · View at Scopus
  91. R. L. Santos, C. M. Silva, A. F. C. Ribeiro et al., “Effect of growth hormone and induced IGF-I release on germ cell population and apoptosis in the bovine testis,” Theriogenology, vol. 51, no. 5, pp. 975–984, 1999. View at Publisher · View at Google Scholar · View at Scopus
  92. C. A. Awoniyi, D. N. R. Veeramachaneni, D. Roberts, K. E. Tucker, V. Chandrashekar, and W. D. Schlaff, “Suppression of growth hormone does not affect ongoing spermatogenesis in rats,” Journal of Andrology, vol. 20, no. 1, pp. 102–108, 1999. View at Google Scholar · View at Scopus
  93. M. Andreassen, R. B. Jensen, N. Jørgensen, and A. Juul, “Association between GH receptor polymorphism (exon 3 deletion), serum IGF1, semen quality, and reproductive hormone levels in 838 healthy young men,” European Journal of Endocrinology, vol. 170, no. 4, pp. 555–563, 2014. View at Publisher · View at Google Scholar · View at Scopus
  94. S. Shirnonovitzl, D. Zacut, A. Ben Chetrit, and M. Ron, “Growth hormone status in patients with maturation arrest of spermatogenesis,” Human Reproduction, vol. 8, no. 6, pp. 919–921, 1993. View at Google Scholar · View at Scopus
  95. P. Ovesen, J. O. L. Jorgensen, J. Ingerslev, K. K. Y. Ho, H. Orskov, and J. S. Christiansen, “Growth hormone treatment of subfertile males,” Fertility and Sterility, vol. 66, no. 2, pp. 292–298, 1996. View at Google Scholar · View at Scopus
  96. A. Radicioni, E. Paris, F. Dondero, V. Bonifacio, and A. Isidori, “Recombinant-growth hormone (rec-hGH) therapy in infertile men with idiopathic oligozoospermia.,” Acta Europaea fertilitatis, vol. 25, no. 5, pp. 311–317, 1994. View at Google Scholar · View at Scopus
  97. M. Bingol-Kologlu, G. B. Bahadir, R. Vargun et al., “Effects of local and sustained release of FGF, IGF, and GH on germ cells in unilateral undescended testis in rats,” Urology, vol. 75, no. 1, pp. 223–228, 2010. View at Publisher · View at Google Scholar · View at Scopus
  98. Y. Zalel, E. Draysen, R. Goldschmit, Z. Zadik, and Z. Shoham, “A prospective pilot study of co-treatment with growth hormone and gonadotropins for improving spermatogenesis in normogonadotropic patients with severe oligoteratoasthenospermia,” Gynecological Endocrinology, vol. 10, no. 1, pp. 23–28, 1996. View at Google Scholar · View at Scopus
  99. Z.-R. Miao, T. K. Lin, T. A. Bongso, X. Zhou, P. Cohen, and K.-O. Lee, “Effect of insulin-like growth factors (IGFs) and IGF-binding proteins on in vitro sperm motility,” Clinical Endocrinology, vol. 49, no. 2, pp. 235–239, 1998. View at Publisher · View at Google Scholar · View at Scopus
  100. J. E. Rowland, L. M. Kerr, M. White, P. G. Noakes, and M. J. Waters, “Heterozygote effects in mice with partial truncations in the growth hormone receptor cytoplasmic domain: assessment of growth parameters and phenotype,” Endocrinology, vol. 146, no. 12, pp. 5278–5286, 2005. View at Publisher · View at Google Scholar · View at Scopus
  101. M. Vergara, M. Smith-Wheelock, J. M. Harper, R. Sigler, and R. A. Miller, “Hormone-treated Snell dwarf mice regain fertility but remain long lived and disease resistant,” The Journals of Gerontology A: Biological Sciences and Medical Sciences, vol. 59, no. 12, pp. 1244–1250, 2004. View at Publisher · View at Google Scholar · View at Scopus
  102. J. X. Zheng, Z. Z. Liu, and N. Yang, “Deficiency of growth hormone receptor does not affect male reproduction in dwarf chickens,” Poultry Science, vol. 86, no. 1, pp. 112–117, 2007. View at Publisher · View at Google Scholar · View at Scopus
  103. G. Untergasser, M. Hermann, H. Rumpold, and P. Berger, “Complex alternative splicing of the GH-V gene in the human testis,” European Journal of Endocrinology, vol. 139, no. 4, pp. 424–427, 1998. View at Publisher · View at Google Scholar · View at Scopus
  104. P. Berger, G. Untergasser, M. Hermann, A. Hittmair, S. Madersbacher, and S. Dirnhofer, “The testis-specific expression pattern of the growth hormone/placental lactogen (GH/PL) gene cluster changes with malignancy,” Human Pathology, vol. 30, no. 10, pp. 1201–1206, 1999. View at Publisher · View at Google Scholar · View at Scopus
  105. A. A. Sciara, J. A. Rubiolo, G. M. Somoza, and S. E. Arranz, “Molecular cloning, expression and immunological characterization of pejerrey (Odontesthes bonariensis) growth hormone,” Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology, vol. 142, no. 3-4, pp. 284–292, 2006. View at Publisher · View at Google Scholar · View at Scopus
  106. A. L. Filby and C. R. Tyler, “Cloning and characterization of cDNAs for hormones and/or receptors of growth hormone, insulin-like growth factor-I, thyroid hormone, and corticosteroid and the gender-, tissue-, and developmental-specific expression of their mRNA transcripts in fathead minnow (Pimephales promelas),” General and Comparative Endocrinology, vol. 150, no. 1, pp. 151–163, 2007. View at Publisher · View at Google Scholar · View at Scopus
  107. S. Harvey, M.-L. Baudet, A. Murphy, M. Luna, K. L. Hull, and C. Aramburo, “Testicular growth hormone (GH): GH expression in spermatogonia and primary spermatocytes,” General and Comparative Endocrinology, vol. 139, no. 2, pp. 158–167, 2004. View at Publisher · View at Google Scholar · View at Scopus
  108. M. Luna, L. Huerta, L. Berumen, H. Martínez-Coria, S. Harvey, and C. Arámburo, “Growth hormone in the male reproductive tract of the chicken: heterogeneity and changes during ontogeny and maturation,” General and Comparative Endocrinology, vol. 137, no. 1, pp. 37–49, 2004. View at Publisher · View at Google Scholar · View at Scopus
  109. J. García-Aragón, P. E. Lobie, G. E. O. Muscat, K. S. Gobius, G. Norstedt, and M. J. Waters, “Prenatal expression of the growth hormone (GH) receptor/binding protein in the rat: a role for GH in embryonic and fetal development?” Development, vol. 114, no. 4, pp. 869–876, 1992. View at Google Scholar · View at Scopus
  110. P. E. Lobie, W. Breipohl, J. G. Aragón, and M. J. Waters, “Cellular localization of the growth hormone receptor/binding protein in the male and female reproductive systems,” Endocrinology, vol. 126, no. 4, pp. 2214–2221, 1990. View at Publisher · View at Google Scholar · View at Scopus
  111. A. L. Pierce, B. K. Fox, L. K. Davis et al., “Prolactin receptor, growth hormone receptor, and putative somatolactin receptor in Mozambique tilapia: tissue specific expression and differential regulation by salinity and fasting,” General and Comparative Endocrinology, vol. 154, no. 1–3, pp. 31–40, 2007. View at Publisher · View at Google Scholar · View at Scopus
  112. J. M. Gomez, M. Loir, and F. Le Gac, “Growth hormone receptors in testis and liver during the spermatogenetic cycle in rainbow trout (Oncorhynchus mykiss),” Biology of Reproduction, vol. 58, no. 2, pp. 483–491, 1998. View at Publisher · View at Google Scholar · View at Scopus
  113. C. G. Martínez-Moreno, L. Palma, M. Carranza, S. Harvey, C. Arámburo, and M. Luna, “Cellular and intracellular distribution of growth hormone in the adult chicken testis,” General and Comparative Endocrinology, vol. 172, no. 3, pp. 344–357, 2011. View at Publisher · View at Google Scholar · View at Scopus
  114. E. B. Berensztein, M. S. Baquedano, C. M. Pepe et al., “Role of IGFs and insulin in the human testis during postnatal activation: differentiation of steroidogenic cells,” Pediatric Research, vol. 63, no. 6, pp. 662–666, 2008. View at Publisher · View at Google Scholar · View at Scopus
  115. M. R. N'Diaye, S. S. Sun, S. P. Fanua, K. J. Loseth, E. F. Shaw Wilgis, and B. G. Crabo, “Growth hormone receptors in the porcine testis during prepuberty,” Reproduction in Domestic Animals, vol. 37, no. 5, pp. 305–309, 2002. View at Publisher · View at Google Scholar · View at Scopus
  116. X. Ma, X. Liu, Y. Zhang, P. Zhu, W. Ye, and H. Lin, “Two growth hormone receptors in Nile tilapia (Oreochromis niloticus): molecular characterization, tissue distribution and expression profiles in the gonad during the reproductive cycle,” Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, vol. 147, no. 2, pp. 325–339, 2007. View at Publisher · View at Google Scholar · View at Scopus
  117. L. K. Davis, A. L. Pierce, N. Hiramatsu, C. V. Sullivan, T. Hirano, and E. G. Grau, “Gender-specific expression of multiple estrogen receptors, growth hormone receptors, insulin-like growth factors and vitellogenins, and effects of 17β-estradiol in the male tilapia (Oreochromis mossambicus),” General and Comparative Endocrinology, vol. 156, no. 3, pp. 544–551, 2008. View at Publisher · View at Google Scholar · View at Scopus
  118. S. Kajimura, N. Kawaguchi, T. Kaneko et al., “Identification of the growth hormone receptor in an advanced teleost, the tilapia (Oreochromis mossambicus) with special reference to its distinct expression pattern in the ovary,” Journal of Endocrinology, vol. 181, no. 1, pp. 65–76, 2004. View at Publisher · View at Google Scholar · View at Scopus
  119. D. L. Y. Tse, M. C. L. Tse, C. B. Chan et al., “Seabream growth hormone receptor: molecular cloning and functional studies of the full-length cDNA, and tissue expression of two alternatively spliced forms,” Biochimica et Biophysica Acta, vol. 1625, no. 1, pp. 64–76, 2003. View at Publisher · View at Google Scholar · View at Scopus
  120. R. Gallego Gómez, E. Pintos, T. García-Caballero et al., “Cellular distribution of growth hormone-releasing hormone receptor in human reproductive system and breast and prostate cancers,” Histology and Histopathology, vol. 20, no. 3, pp. 697–706, 2005. View at Google Scholar · View at Scopus
  121. C. G. Martínez-Moreno, L. M. López-Marín, M. Carranza et al., “Growth hormone (GH) and GH-releasing hormone (GHRH): co-localization and action in the chicken testis,” General and Comparative Endocrinology, vol. 199, pp. 38–45, 2014. View at Publisher · View at Google Scholar · View at Scopus
  122. Z. Wang, “New doctorial cancer research: novel animal models to study the role of the growth hormone insulin-like growth factor I axis in prostate cancer,” Critical Reviews in Oncogenesis, vol. 12, no. 3-4, pp. 291–293, 2006. View at Publisher · View at Google Scholar · View at Scopus
  123. M. Tena-Sempere, “Exploring the role of ghrelin as novel regulator of gonadal function,” Growth Hormone and IGF Research, vol. 15, no. 2, pp. 83–88, 2005. View at Publisher · View at Google Scholar · View at Scopus
  124. M. L. Barreiro and M. Tena-Sempere, “Ghrelin and reproduction: a novel signal linking energy status and fertility?” Molecular and Cellular Endocrinology, vol. 226, no. 1-2, pp. 1–9, 2004. View at Publisher · View at Google Scholar · View at Scopus
  125. J. I. Jones and D. R. Clemmons, “Insulin-like growth factors and their binding proteins: biological actions,” Endocrine Reviews, vol. 16, no. 1, pp. 3–34, 1995. View at Google Scholar · View at Scopus
  126. D. Dombrowicz, E. L. Hooghe-Peters, A. Gothot et al., “Cellular localization of IGF-I and IGF-II mRNAs in immature hypophysectomized rat testis and epididymis after in vivo hormonal treatment,” Archives Internationales de Physiologie , de Biochimie et de Biophysique, vol. 100, no. 5, pp. 303–308, 1992. View at Publisher · View at Google Scholar · View at Scopus
  127. J. F. Roser, “Regulation of testicular function in the stallion: an intricate network of endocrine, paracrine and autocrine systems,” Animal Reproduction Science, vol. 107, no. 3-4, pp. 179–196, 2008. View at Publisher · View at Google Scholar · View at Scopus
  128. M. Tanaka, Y. Hayashida, K. Sakaguchi et al., “Growth hormone-independent expression of insulin-like growth factor I messenger ribonucleic acid in extrahepatic tissues of the chicken,” Endocrinology, vol. 137, no. 1, pp. 30–34, 1996. View at Publisher · View at Google Scholar · View at Scopus
  129. Q. P. Vong, K. M. Chan, and C. H. K. Cheng, “Quantification of common carp (Cyprinus carpio) IGF-I and IGF-II mRNA by real-time PCR: Differential regulation of expression by GH,” Journal of Endocrinology, vol. 178, no. 3, pp. 513–521, 2003. View at Publisher · View at Google Scholar · View at Scopus
  130. E. J. Sanders and S. Harvey, “Growth hormone as an early embryonic growth and differentiation factor,” Anatomy and Embryology, vol. 209, no. 1, pp. 1–9, 2004. View at Publisher · View at Google Scholar · View at Scopus
  131. W. Ruan, L. Powell-Braxton, J. J. Kopchick, and D. L. Kleinberg, “Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development,” Endocrinology, vol. 140, no. 5, pp. 1984–1989, 1999. View at Google Scholar · View at Scopus
  132. A. Bartke, V. Chandrashekar, D. Turyn et al., “Effects of growth hormone overexpression and growth hormone resistance on neuroendocrine and reproductive functions in transgenic and knock-out mice,” Proceedings of the Society for Experimental Biology and Medicine, vol. 222, no. 2, pp. 113–123, 1999. View at Publisher · View at Google Scholar · View at Scopus
  133. E. Reiter, B. Hunnuy, M. Bryninx et al., “Effects of pituitary hormones on the prostate,” Prostate, vol. 38, no. 2, pp. 159–165, 1999. View at Google Scholar
  134. E. Reiter, O. Kecha, B. Hennuy et al., “Growth hormone directly affects the function of the different lobes of the rat prostate,” Endocrinology, vol. 136, no. 8, pp. 3338–3345, 1995. View at Google Scholar · View at Scopus
  135. A. Colao, P. Marzullo, S. Spiezia, and G. Lombardi, “Acromegaly and prostate cancer,” Growth Hormone & IGF Research, vol. 10, supplement 1, pp. S37–S38, 2000. View at Publisher · View at Google Scholar · View at Scopus
  136. S. Loeper and S. Ezzat, “Acromegaly: re-thinking the cancer risk,” Reviews in Endocrine and Metabolic Disorders, vol. 9, no. 1, pp. 41–58, 2008. View at Publisher · View at Google Scholar · View at Scopus
  137. B. Fuhrman, M. Barba, H. J. Schünemann et al., “Basal growth hormone concentrations in blood and the risk for prostate cancer: a case-control study,” Prostate, vol. 64, no. 2, pp. 109–115, 2005. View at Publisher · View at Google Scholar · View at Scopus
  138. A. Colao, P. Marzullo, S. Spiezia et al., “Effect of growth hormone (GH) and insulin-like growth factor I on prostate diseases: an ultrasonographic and endocrine study in acromegaly, GH deficiency, and healthy subjects,” Journal of Clinical Endocrinology and Metabolism, vol. 84, no. 6, pp. 1986–1991, 1999. View at Publisher · View at Google Scholar · View at Scopus
  139. C. W. le Roux, P. J. Jenkins, S. L. Chew et al., “Growth hormone replacement does not increase serum prostate-specific antigen in hypopituitary men over 50 years,” European Journal of Endocrinology, vol. 147, no. 1, pp. 59–63, 2002. View at Publisher · View at Google Scholar · View at Scopus
  140. A. Colao, C. Di Somma, S. Spiezia, M. Filippella, R. Pivonello, and G. Lombardi, “Effect of growth hormone (GH) and/or testosterone replacement on the prostate in GH-deficient adult patients,” The Journal of Clinical Endocrinology & Metabolism, vol. 88, no. 1, pp. 88–94, 2003. View at Publisher · View at Google Scholar · View at Scopus
  141. A. Siejka, A. V. Schally, N. L. Block, and N. Barabutis, “Antagonists of growth hormone-releasing hormone inhibit the proliferation of human benign prostatic hyperplasia cells,” Prostate, vol. 70, no. 10, pp. 1087–1093, 2010. View at Publisher · View at Google Scholar · View at Scopus
  142. N. Barabutis, A. Siejka, and A. V. Schally, “Effects of growth hormone-releasing hormone and its agonistic and antagonistic analogs in cancer and non-cancerous cell lines,” International Journal of Oncology, vol. 36, no. 5, pp. 1285–1289, 2010. View at Publisher · View at Google Scholar · View at Scopus
  143. A. V. Schally, J. L. Varga, and J. B. Engel, “Antagonists of growth-hormone-releasing hormone: an emerging new therapy for cancer,” Nature Clinical Practice Endocrinology & Metabolism, vol. 4, no. 1, pp. 33–43, 2008. View at Publisher · View at Google Scholar · View at Scopus
  144. L. Muñoz-Moreno, M. I. Arenas, A. V. Schally et al., “Inhibitory effects of antagonists of growth hormone-releasing hormone on growth and invasiveness of PC3 human prostate cancer,” International Journal of Cancer, vol. 132, no. 4, pp. 755–765, 2013. View at Publisher · View at Google Scholar · View at Scopus
  145. C. D. Fahrenholtz, F. G. Rick, M. I. Garcia et al., “Preclinical efficacy of growth hormone-releasing hormone antagonists for androgen-dependent and castration-resistant human prostate cancer,” Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 3, pp. 1084–1089, 2014. View at Publisher · View at Google Scholar · View at Scopus
  146. Z. Wang, R. M. Luque, R. D. Kineman et al., “Disruption of growth hormone signaling retards prostate carcinogenesis in the probasin/Tag rat,” Endocrinology, vol. 149, no. 3, pp. 1366–1376, 2008. View at Publisher · View at Google Scholar · View at Scopus
  147. Z. Wang, G. S. Prins, K. T. Coschigano et al., “Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)/T antigen mouse,” Endocrinology, vol. 146, no. 12, pp. 5188–5196, 2005. View at Publisher · View at Google Scholar · View at Scopus
  148. K. Takahara, H. Tearle, M. Ghaffari, M. E. Gleave, M. Pollak, and M. E. Cox, “Human prostate cancer xenografts in lit/lit mice exhibit reduced growth and androgen-independent progression,” Prostate, vol. 71, no. 5, pp. 525–537, 2011. View at Publisher · View at Google Scholar · View at Scopus
  149. A. O. Nakonechnaya, H. S. Jefferson, X. Chen, and B. M. Shewchuk, “Differential effects of exogenous and autocrine growth hormone on LNCaP prostate cancer cell proliferation and survival,” Journal of Cellular Biochemistry, vol. 114, no. 6, pp. 1322–1335, 2013. View at Publisher · View at Google Scholar · View at Scopus
  150. G. Untergasser, H. Rumpold, M. Hermann, S. Dirnhofer, G. Jilg, and P. Berger, “Proliferative disorders of the aging human prostate: involvement of protein hormones and their receptors,” Experimental Gerontology, vol. 34, no. 2, pp. 275–287, 1999. View at Publisher · View at Google Scholar · View at Scopus
  151. L. K. Chopin, T. L. Veveris-Lowe, A. F. Philipps, and A. C. Herington, “Co-expression of GH and GHR isoforms in prostate cancer cell lines,” Growth Hormone & IGF Research, vol. 12, no. 2, pp. 126–136, 2002. View at Publisher · View at Google Scholar · View at Scopus
  152. E. Weiss-Messer, O. Merom, A. Adi et al., “Growth hormone (GH) receptors in prostate cancer: gene expression in human tissues and cell lines and characterization, GH signaling and androgen receptor regulation in LNCaP cells,” Molecular and Cellular Endocrinology, vol. 220, no. 1-2, pp. 109–123, 2004. View at Publisher · View at Google Scholar · View at Scopus
  153. M. Bidosee, R. Karry, E. Weiss-Messer, and R. J. Barkey, “Regulation of growth hormone receptors in human prostate cancer cell lines,” Molecular and Cellular Endocrinology, vol. 309, no. 1-2, pp. 82–92, 2009. View at Publisher · View at Google Scholar · View at Scopus
  154. M. D. Slater and C. R. Murphy, “Co-expression of interleukin-6 and human growth hormone in apparently normal prostate biopsies that ultimately progress to prostate cancer using low pH, high temperature antigen retrieval,” Journal of Molecular Histology, vol. 37, no. 1-2, pp. 37–41, 2006. View at Publisher · View at Google Scholar · View at Scopus
  155. M. Slater, M. Cooper, and C. R. Murphy, “Human growth hormone and interleukin-6 are upregulated in endometriosis and endometrioid adenocarcinoma,” Acta Histochemica, vol. 108, no. 1, pp. 13–18, 2006. View at Publisher · View at Google Scholar · View at Scopus
  156. C. Ohlsson, S. Mohan, K. Sjögren et al., “The role of liver-derived insulin-like growth factor-I,” Endocrine Reviews, vol. 30, no. 5, pp. 494–535, 2009. View at Publisher · View at Google Scholar · View at Scopus
  157. A. A. Samani, S. Yakar, D. LeRoith, and P. Brodt, “The role of the IGF system in cancer growth and metastasis: overview and recent insights,” Endocrine Reviews, vol. 28, no. 1, pp. 20–47, 2007. View at Publisher · View at Google Scholar · View at Scopus
  158. M. Bidosee, R. Karry, E. Weiss-Messer, and R. J. Barkey, “Growth hormone affects gene expression and proliferation in human prostate cancer cells,” International Journal of Andrology, vol. 34, no. 2, pp. 124–137, 2011. View at Publisher · View at Google Scholar · View at Scopus
  159. D. Iglesias-Gato, Y.-C. Chuan, P. Wikström et al., “SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer,” Carcinogenesis, vol. 35, no. 1, pp. 24–33, 2014. View at Publisher · View at Google Scholar · View at Scopus
  160. Z. Laron and R. Sarel, “Penis and testicular size in patients with growth hormone insufficency,” Acta Endocrinologica, vol. 63, no. 4, pp. 625–633, 1970. View at Google Scholar · View at Scopus
  161. Z. Laron, F. Mimouni, and A. Pertzelan, “Effect of human growth hormone therapy on penile and testicular size in boys with isolated growth hormone deficiency: first year of treatment,” Israel Journal of Medical Sciences, vol. 19, no. 4, pp. 338–344, 1983. View at Google Scholar · View at Scopus
  162. J. B. Levy and D. A. Husmann, “Micropenis secondary to growth hormone deficiency: does treatment with growth hormone alone result in adequate penile growth?” Journal of Urology, vol. 156, no. 1, pp. 214–216, 1996. View at Publisher · View at Google Scholar · View at Scopus
  163. K. D. Dykstra, A. M. Payne, M. Abdelrahim, and G. L. Francis, “Insulin-like growth factor 1, but not growth hormone, has in vitro proliferative effects on neonatal foreskin fibroblasts without affecting 5- α-reductase or androgen receptor activity,” Journal of Andrology, vol. 14, no. 2, pp. 73–78, 1993. View at Google Scholar · View at Scopus
  164. S. W. Lee, S. H. Kim, J. Y. Kim, and Y. Lee, “The effect of growth hormone on fibroblast proliferation and keratinocyte migration,” Journal of Plastic, Reconstructive and Aesthetic Surgery, vol. 63, no. 4, pp. e364–e369, 2010. View at Publisher · View at Google Scholar · View at Scopus
  165. E. A. Hamed, A. R. M. A. Meki, A. A. A. Gaafar, and S. A. Hamed, “Role of some vasoactive mediators in patients with erectile dysfunction: their relationship with angiotensin-converting enzyme and growth hormone,” International Journal of Impotence Research, vol. 15, no. 6, pp. 418–425, 2003. View at Publisher · View at Google Scholar · View at Scopus
  166. A. J. Becker, S. Ückert, C. G. Stief et al., “Serum levels of human growth hormone during different penile conditions in the cavernous and systemic blood of healthy men and patients with erectile dysfunction,” Urology, vol. 59, no. 4, pp. 609–614, 2002. View at Publisher · View at Google Scholar · View at Scopus
  167. T. Krüger, M. S. Exton, C. Pawlak, A. V. Z. Mühlen, U. Hartmann, and M. Schedlowski, “Neuroendocrine and cardiovascular response to sexual arousal and orgasm in men,” Psychoneuroendocrinology, vol. 23, no. 4, pp. 401–411, 1998. View at Publisher · View at Google Scholar · View at Scopus
  168. X.-S. Zhang, Y.-X. Wang, Y.-F. Han et al., “Effects of growth hormone supplementation on erectile function and expression of nNOS in aging rats,” Zhonghua Nan Ke Xue, vol. 11, no. 5, pp. 339–342, 2005. View at Google Scholar · View at Scopus
  169. X. Huang, L.-Q. Hu, and B.-Q. Tian, “Growth hormone enhances regeneration of nNOS-containing nerve fibers in the aged rat penis,” Zhonghua Nan Ke Xue, vol. 11, no. 2, pp. 98–100, 2005. View at Google Scholar · View at Scopus
  170. D.-S. Cui, K.-L. Zhang, F. Pei, S.-Z. Wei, and L.-Q. Hu, “Growth hormone enhances regeneration of cavernous nerves after their transplantation in rats,” National Journal of Andrology, vol. 12, no. 9, pp. 784–790, 2006. View at Google Scholar · View at Scopus
  171. G.-W. Jung, E. M. Spencer, and T. F. Lue, “Growth hormone enhances regeneration of nitric oxide synthase-containing penile nerves after cavernous nerve neurotomy in rats,” The Journal of Urology, vol. 160, no. 5, pp. 1899–1904, 1998. View at Publisher · View at Google Scholar · View at Scopus
  172. G. W. Jung, J. Y. Kwak, S. Yoon, J. H. Yoon, and T. F. Lue, “IGF-I and TGF-β2 have a key role an regeneration of nitric oxide synthase (NOS)-containing nerves after cavernous neurotomy in rats,” International Journal of Impotence Research, vol. 11, no. 5, pp. 247–259, 1999. View at Publisher · View at Google Scholar · View at Scopus
  173. A. J. Becker, S. Ückert, C. G. Stief et al., “Possible role of human growth hormone in penile erection,” The Journal of Urology, vol. 164, no. 6, pp. 2138–2142, 2000. View at Publisher · View at Google Scholar · View at Scopus
  174. S. Ückert, F. Scheller, C. G. Stief et al., “Potential mechanism of action of human growth hormone on isolated human penile erectile tissue,” Urology, vol. 75, no. 4, pp. 968–973, 2010. View at Publisher · View at Google Scholar · View at Scopus
  175. A. Jadresic, L. M. Banks, D. F. Child et al., “The acromegaly syndrome. Relation between clinical features, growth hormone values and radiological characteristics of the pituitary tumours,” Quarterly Journal of Medicine, vol. 51, no. 202, pp. 189–204, 1982. View at Google Scholar
  176. S. Ra, H. Aoki, T. Fujioka, F. Sato, T. Kubo, and N. Yasuda, “In vitro contraction of the canine corpus cavernosum penis by direct perfusion with prolactin or growth hormone,” Journal of Urology, vol. 156, no. 2, pp. 522–525, 1996. View at Publisher · View at Google Scholar · View at Scopus
  177. B. Rejduch, E. Słota, P. Sysa, and M. Rózycki, “Reproductive performance of a transgenic boar carrying the bovine growth hormone gene (bGH),” Journal of Applied Genetics, vol. 43, no. 3, pp. 337–341, 2002. View at Google Scholar · View at Scopus
  178. V. G. Pursel, D. J. Bolt, K. F. Miller et al., “Expression and performance in transgenic pigs,” Journal of Reproduction and Fertility, Supplement, vol. 40, pp. 235–245, 1990. View at Google Scholar · View at Scopus
  179. C. A. Pinkert, D. L. Kooyman, and T. J. Dyer, “Enhanced growth performance in transgenic swine,” Biotechnology, vol. 16, pp. 251–258, 1991. View at Google Scholar · View at Scopus
  180. K. Fujita, H. Terada, and L. Z. Ling, “Male sexual insufficiency,” Nippon Rinsho, vol. 55, no. 11, pp. 2908–2913, 1997. View at Google Scholar · View at Scopus
  181. J. A. M. De Boer, J. Schoemaker, and E. A. Van Der Veen, “Impaired reproductive function in women treated for growth hormone deficiency during childhood,” Clinical Endocrinology, vol. 46, no. 6, pp. 681–689, 1997. View at Publisher · View at Google Scholar · View at Scopus
  182. A. Giampietro, D. Milardi, A. Bianchi et al., “The effect of treatment with growth hormone on fertility outcome in eugonadal women with growth hormone deficiency: report of four cases and review of the literature,” Fertility and Sterility, vol. 91, no. 3, pp. 930.e7–930.11, 2009. View at Publisher · View at Google Scholar · View at Scopus
  183. J. G. Gong, T. Bramley, and R. Webb, “The effect of recombinant bovine somatotropin on ovarian function in heifers: follicular populations and peripheral hormones,” Biology of Reproduction, vol. 45, no. 6, pp. 941–949, 1991. View at Publisher · View at Google Scholar · View at Scopus
  184. F. Moreira, C. Orlandi, C. A. Risco, R. Mattos, F. Lopes, and W. W. Thatcher, “Effects of presynchronization and bovine somatotropin on pregnancy rates to a timed artificial insemination protocol in lactating dairy cows,” Journal of Dairy Science, vol. 84, no. 7, pp. 1646–1659, 2001. View at Publisher · View at Google Scholar · View at Scopus
  185. M. J. Starbuck, E. K. Inskeep, and R. A. Dailey, “Effect of a single growth hormone (rbST) treatment at breeding on conception rates and pregnancy retention in dairy and beef cattle,” Animal Reproduction Science, vol. 93, no. 3-4, pp. 349–359, 2006. View at Publisher · View at Google Scholar · View at Scopus
  186. M. Yigiter, Z. Halici, F. Odabasoglu et al., “Growth hormone reduces tissue damage in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 157, no. 1, pp. 94–100, 2011. View at Publisher · View at Google Scholar · View at Scopus
  187. I. Chatzistamou, A. V. Schally, J. L. Varga, K. Groot, P. Armatis, and A. Bajo, “Inhibition of growth and reduction in tumorigenicity of UCI-107 ovarian cancer by antagonists of growth hormone-releasing hormone and vasoactive intestinal peptide,” Journal of Cancer Research and Clinical Oncology, vol. 127, no. 11, pp. 645–652, 2001. View at Publisher · View at Google Scholar · View at Scopus
  188. R. Webb, P. C. Garnsworthy, J.-G. Gong, and D. G. Armstrong, “Control of follicular growth: local interactions and nutritional influences,” Journal of Animal Science, vol. 82, pp. E63–E74, 2004. View at Google Scholar · View at Scopus
  189. S. Tanghe, A. Van Soom, H. Nauwynck, M. Coryn, and A. De Kruif, “Minireview: functions of the cumulus oophorus during oocyte maturation, ovulation, and fertilization,” Molecular Reproduction and Development, vol. 61, no. 3, pp. 414–424, 2002. View at Publisher · View at Google Scholar · View at Scopus
  190. A. V. Sirotkin, A. V. Makarevich, and L. Hetényi, “Effect of growth hormone and inhibitors of protein kinase a on IGF-I, oxytocin and progesterone release by cultured bovine granulosa cells,” Annales d'Endocrinologie, vol. 61, no. 2, pp. 154–158, 2000. View at Google Scholar · View at Scopus
  191. A. V. Sirotkin, “Direct action of growth hormone on bovine ovarian cells: effects on estradiol, oxytocin, vasopressin release by granulosa cells and on oocyte maturation and cleavage in vitro,” Annales d'Endocrinologie, vol. 57, no. 3, pp. 219–224, 1996. View at Google Scholar · View at Scopus
  192. M. Karamouti, P. Kollia, A. Kallitsaris, N. Vamvakopoulos, G. Kollios, and I. E. Messinis, “Growth hormone, insulin-like growth factor I, and leptin interaction in human cultured lutein granulosa cells steroidogenesis,” Fertility and Sterility, vol. 90, no. 4, pp. 1444–1450, 2008. View at Publisher · View at Google Scholar · View at Scopus
  193. N. Doldi, M. Bassan, V. Bonzi, and A. Ferrari, “Effects of growth hormone and growth hormone-releasing hormone on steroid synthesis in cultured human luteinizing granulosa cells,” Gynecological Endocrinology, vol. 10, no. 2, pp. 101–108, 1996. View at Google Scholar · View at Scopus
  194. E. Ł. Gregoraszczuk and A. Ptak, “In vitro effect of leptin on growth hormone (GH)- and insulin-like growth factor-I (IGF-I)-stimulated progesterone secretion and apoptosis in developing and mature corpora lutea of pig ovaries,” Journal of Reproduction and Development, vol. 51, no. 6, pp. 727–733, 2005. View at Publisher · View at Google Scholar · View at Scopus
  195. E. L. Gregoraszczuk, A. Ptak, A. K. Wojtowicz, T. Gorska, and K. W. Nowak, “Estrus cycle-dependent action of leptin on basal and GH or IGF-I stimulated steroid secretion by whole porcine follicles,” Endocrine Regulations, vol. 38, no. 1, pp. 15–21, 2004. View at Google Scholar · View at Scopus
  196. E. Nakamura, F. Otsuka, K. Inagaki et al., “Mutual regulation of growth hormone and bone morphogenetic protein system in steroidogenesis by rat granulosa cells,” Endocrinology, vol. 153, no. 1, pp. 469–480, 2012. View at Publisher · View at Google Scholar · View at Scopus
  197. J. K. Nyholt de Prada, L. D. Kellam, B. G. Patel, K. E. Latham, and C. A. Vandevoort, “Growth hormone and gene expression of in vitro-matured rhesus macaque oocytes,” Molecular Reproduction and Development, vol. 77, no. 4, pp. 353–362, 2010. View at Publisher · View at Google Scholar · View at Scopus
  198. L. P. Andrade, S. M. Rhind, I. A. Wright, S. R. McMillen, P. J. Goddard, and T. A. Bramley, “Effects of bovine somatotrophin (bST) on ovarian function in post-partum beef cows,” Reproduction, Fertility and Development, vol. 8, no. 6, pp. 951–960, 1996. View at Publisher · View at Google Scholar · View at Scopus
  199. N. M. Cox, “Control of follicular development and ovulation rate in pigs,” Journal of Reproduction and Fertility. Supplement, vol. 52, pp. 31–46, 1997. View at Google Scholar · View at Scopus
  200. T. Taketani, Y. Yamagata, A. Takasaki, A. Matsuoka, H. Tamura, and N. Sugino, “Effects of growth hormone and insulin-like growth factor 1 on progesterone production in human luteinized granulosa cells,” Fertility and Sterility, vol. 90, no. 3, pp. 744–748, 2008. View at Publisher · View at Google Scholar · View at Scopus
  201. C. C. Chase Jr., C. J. Kirby, A. C. Hammond, T. A. Olson, and M. C. Lucy, “Patterns of ovarian growth and development in cattle with a growth hormone receptor deficiency,” Journal of Animal Science, vol. 76, no. 1, pp. 212–219, 1998. View at Google Scholar · View at Scopus
  202. A. Hrabia, A. Sechman, A. Gertler, and J. Rza̧sa, “Effect of growth hormone on steroid content, proliferation and apoptosis in the chicken ovary during sexual maturation,” Cell and Tissue Research, vol. 345, no. 1, pp. 191–202, 2011. View at Publisher · View at Google Scholar · View at Scopus
  203. A. K. Singh and B. Lal, “Seasonal and circadian time-dependent dual action of GH on somatic growth and ovarian development in the Asian catfish, Clarias batrachus (Linn.): role of temperature,” General and Comparative Endocrinology, vol. 159, no. 1, pp. 98–106, 2008. View at Publisher · View at Google Scholar · View at Scopus
  204. F. Otsuka, K. J. McTavish, and S. Shimasaki, “Integral role of GDF-9 and BMP-15 in ovarian function,” Molecular Reproduction and Development, vol. 78, no. 1, pp. 9–21, 2011. View at Publisher · View at Google Scholar · View at Scopus
  205. R. B. Gilchrist, “Recent insights into oocytefollicle cell interactions provide opportunities for the development of new approaches to in vitro maturation,” Reproduction, Fertility and Development, vol. 23, no. 1, pp. 23–31, 2011. View at Publisher · View at Google Scholar · View at Scopus
  206. J. R. V. Silva, J. R. Figueiredo, and R. van den Hurk, “Involvement of growth hormone (GH) and insulin-like growth factor (IGF) system in ovarian folliculogenesis,” Theriogenology, vol. 71, no. 8, pp. 1193–1208, 2009. View at Publisher · View at Google Scholar · View at Scopus
  207. A. Bachelot, P. Monget, P. Imbert-Bolloré et al., “Growth hormone is required for ovarian follicular growth,” Endocrinology, vol. 143, no. 10, pp. 4104–4112, 2002. View at Publisher · View at Google Scholar · View at Scopus
  208. K. A. Slot, J. Kastelijn, A. Bachelot, P. A. Kelly, N. Binart, and K. J. Teerds, “Reduced recruitment and survival of primordial and growing follicles in GH receptor-deficient mice,” Reproduction, vol. 131, no. 3, pp. 525–532, 2006. View at Publisher · View at Google Scholar · View at Scopus
  209. O. Semiz and O. Evirgen, “The effect of growth hormone on ovarian follicular response and oocyte nuclear maturation in young and aged mice,” Acta Histochemica, vol. 111, no. 2, pp. 104–111, 2009. View at Publisher · View at Google Scholar · View at Scopus
  210. M. F. Sá Filho, N. A. T. Carvalho, L. U. Gimenes et al., “Effect of recombinant bovine somatotropin (bST) on follicular population and on in vitro buffalo embryo production,” Animal Reproduction Science, vol. 113, no. 1–4, pp. 51–59, 2009. View at Publisher · View at Google Scholar · View at Scopus
  211. P. Gonzalez-Añover, T. Encinas, R. M. Garcia-Garcia et al., “Ovarian response in sheep superovulated after pretreatment with growth hormone and GnRH antagonists is weakened by failures in oocyte maturation,” Zygote, vol. 12, no. 4, pp. 301–304, 2004. View at Publisher · View at Google Scholar · View at Scopus
  212. R. Flores, M. L. Looper, R. W. Rorie, D. M. Hallford, and C. F. Rosenkrans Jr., “Endocrine factors and ovarian follicles are influenced by body condition and somatotropin in postpartum beef cows,” Journal of Animal Science, vol. 86, no. 6, pp. 1335–1344, 2008. View at Publisher · View at Google Scholar · View at Scopus
  213. N. R. Adams and J. R. Briegel, “Multiple effects of an additional growth hormone gene in adult sheep,” Journal of Animal Science, vol. 83, no. 8, pp. 1868–1874, 2005. View at Google Scholar · View at Scopus
  214. Y. S. Lee, C. A. Vandevoort, J. P. Gaughan, U. Midic, Z. Obradovic, and K. E. Latham, “Extensive effects of in vitro oocyte maturation on rhesus monkey cumulus cell transcriptome,” American Journal of Physiology: Endocrinology and Metabolism, vol. 301, no. 1, pp. E196–E209, 2011. View at Publisher · View at Google Scholar · View at Scopus
  215. F. S. Martins, J. J. H. Celestino, M. V. A. Saraiva et al., “Interaction between growth differentiation factor 9, insulin-like growth factor I and growth hormone on the in vitro development and survival of goat preantral follicles,” Brazilian Journal of Medical and Biological Research, vol. 43, no. 8, pp. 728–736, 2010. View at Publisher · View at Google Scholar · View at Scopus
  216. D. M. Magalhães, A. B. G. Duarte, V. R. Araújo et al., “In vitro production of a caprine embryo from a preantral follicle cultured in media supplemented with growth hormone,” Theriogenology, vol. 75, no. 1, pp. 182–188, 2011. View at Publisher · View at Google Scholar · View at Scopus
  217. G. Arunakumari, N. Shanmugasundaram, and V. H. Rao, “Development of morulae from the oocytes of cultured sheep preantral follicles,” Theriogenology, vol. 74, no. 5, pp. 884–894, 2010. View at Publisher · View at Google Scholar · View at Scopus
  218. X. Liu, K. Andoh, H. Yokota et al., “Effects of growth hormone, activin, and follistatin on the development of preantral follicle from immature female mice,” Endocrinology, vol. 139, no. 5, pp. 2342–2347, 1998. View at Publisher · View at Google Scholar · View at Scopus
  219. J. Kobayashi, H. Mizunuma, N. Kikuchi et al., “Morphological assessment of the effect of growth hormone on preantral follicles from 11-day-old mice in an in vitro culture system,” Biochemical and Biophysical Research Communications, vol. 268, no. 1, pp. 36–41, 2000. View at Publisher · View at Google Scholar · View at Scopus
  220. H. A. Hassan, H. Azab, A. A. Rahman, and T. M. Nafee, “Effects of growth hormone on in vitro maturation of germinal vesicle of human oocytes retrieved from small antral follicles,” Journal of Assisted Reproduction and Genetics, vol. 18, no. 8, pp. 417–420, 2001. View at Publisher · View at Google Scholar · View at Scopus
  221. J. K. N. De Prada and C. A. VandeVoort, “Growth hormone and in vitro maturation of rhesus macaque oocytes and subsequent embryo development,” Journal of Assisted Reproduction and Genetics, vol. 25, no. 4, pp. 145–158, 2008. View at Publisher · View at Google Scholar · View at Scopus
  222. F. Izadyar, W. J. Hage, B. Colenbrander, and M. M. Bevers, “The promotory effect of growth hormone on the developmental competence of in vitro matured bovine oocytes is due to improved cytoplasmic maturation,” Molecular Reproduction and Development, vol. 49, no. 4, pp. 444–453, 1998. View at Publisher · View at Google Scholar
  223. N. R. Mtango, M. D. Varisanga, Y. J. Dong, R. Rajamahendran, and T. Suzuki, “Growth factors and growth hormone enhance in vitro embryo production and post-thaw survival of vitrified bovine blastocysts,” Theriogenology, vol. 59, no. 5-6, pp. 1393–1402, 2003. View at Publisher · View at Google Scholar · View at Scopus
  224. E. Pers-Kamczyc, E. Warzych, J. Peippo, and D. Lechniak, “Growth hormone exerts no effect on the timing of the first zygotic cleavage in cattle,” Theriogenology, vol. 74, no. 4, pp. 581–595, 2010. View at Publisher · View at Google Scholar · View at Scopus
  225. F. Moreira, F. F. Paula-Lopes, P. J. Hansen, L. Badinga, and W. W. Thatcher, “Effects of growth hormone and insulin-like growth factor-I on development of in vitro derived bovine embryos,” Theriogenology, vol. 57, no. 2, pp. 895–907, 2002. View at Publisher · View at Google Scholar · View at Scopus
  226. S. E. Pozzobon, M. A. Lagares, D. S. Brum, F. G. Leivas, and M. I. B. Rubin, “Addition of recombinant human growth hormone to in vitro maturation medium of bovine oocytes,” Reproduction in Domestic Animals, vol. 40, no. 1, pp. 19–22, 2005. View at Publisher · View at Google Scholar · View at Scopus
  227. A. Shirazi, N. Shams-Esfandabadi, E. Ahmadi, and B. Heidari, “Effects of growth hormone on nuclear maturation of ovine oocytes and subsequent embryo development,” Reproduction in Domestic Animals, vol. 45, no. 3, pp. 530–536, 2010. View at Publisher · View at Google Scholar · View at Scopus
  228. P. Kezele, E. Nilsson, and M. K. Skinner, “Cell-cell interactions in primordial follicle assembly and development,” Frontiers in Bioscience, vol. 7, pp. d1990–d1996, 2002. View at Publisher · View at Google Scholar · View at Scopus
  229. E. L. Gregoraszczuk, A. Rak, A. Wójtowicz, A. Ptak, T. Wojciechowicz, and K. W. Nowak, “GH and IGF-I increase leptin receptor expression in prepubertal pig ovaries: the role of leptin in steroid secretion and cell apoptosis,” Acta Veterinaria Hungarica, vol. 54, no. 3, pp. 413–426, 2006. View at Publisher · View at Google Scholar · View at Scopus
  230. O. Heikinheimo and W. E. Gibbons, “The molecular mechanisms of oocyte maturation and early embryonic development are unveiling new insights into reproductive medicine,” Molecular Human Reproduction, vol. 4, no. 8, pp. 745–756, 1998. View at Publisher · View at Google Scholar · View at Scopus
  231. S. Chigioni, C. Secchi, V. Borromeo, S. Modina, M. S. Beretta, and G. C. Luvoni, “Effects of growth hormone on oocyte in vitro maturation and its localization in the canine cumulus-oocyte complexes,” Veterinary Research Communications, vol. 32, no. 1, pp. S131–S134, 2008. View at Publisher · View at Google Scholar · View at Scopus
  232. G. R. Pereira, P. L. Lorenzo, G. F. Carneiro et al., “The effect of growth hormone (GH) and insulin-like growth factor-I (IGF-I) on in vitro maturation of equine oocytes,” Zygote, vol. 20, no. 4, pp. 353–360, 2012. View at Publisher · View at Google Scholar · View at Scopus
  233. G. R. Pereira, P. L. Lorenzo, G. F. Carneiro, S. Bilodeau-Goeseels, J. Kastelic, and I. K. M. Liu, “A specific adenylyl cyclase inhibitor (DDA) and a cyclic AMP-dependent protein kinase inhibitor (H-89) block the action of equine growth hormone on in vitro maturation of equine oocytes,” Zygote, pp. 1–7, 2014. View at Publisher · View at Google Scholar
  234. R. Apa, A. Lanzone, F. Miceli et al., “Growth hormone induces in vitro maturation of follicle- and cumulus-enclosed rat oocytes,” Molecular and Cellular Endocrinology, vol. 106, no. 1-2, pp. 207–212, 1994. View at Publisher · View at Google Scholar · View at Scopus
  235. N. Songsasen, I. Yu, and S. P. Leibo, “Nuclear maturation of canine oocytes cultured in protein-free media,” Molecular Reproduction and Development, vol. 62, no. 3, pp. 407–415, 2002. View at Publisher · View at Google Scholar · View at Scopus
  236. S. Kölle, M. Stojkovic, G. Boie, E. Wolf, and F. Sinowatz, “Growth hormone-related effects on apoptosis, mitosis, and expression of connexin 43 in bovine in vitro maturation cumulus-oocyte complexes,” Biology of Reproduction, vol. 68, no. 5, pp. 1584–1589, 2003. View at Publisher · View at Google Scholar · View at Scopus
  237. M. Jamnongjit and S. R. Hammes, “Oocyte maturation: the coming of age of a germ cell,” Seminars in Reproductive Medicine, vol. 23, no. 3, pp. 234–241, 2005. View at Publisher · View at Google Scholar · View at Scopus
  238. R. Marchal, M. Caillaud, A. Martoriati, N. Gérard, P. Mermillod, and G. Goudet, “Effect of growth hormone (GH) on in vitro nuclear and cytoplasmic oocyte maturation, cumulus expansion, hyaluronan synthases, and connexins 32 and 43 expression, and GH receptor messenger RNA expression in equine and porcine species,” Biology of Reproduction, vol. 69, no. 3, pp. 1013–1022, 2003. View at Publisher · View at Google Scholar · View at Scopus
  239. E. Kiapekou, D. Loutradis, P. Drakakis, E. Zapanti, G. Mastorakos, and A. Antsaklis, “Effects of GH and IGF-I on the in vitro maturation of mouse oocytes,” Hormones, vol. 4, no. 3, pp. 155–160, 2005. View at Publisher · View at Google Scholar · View at Scopus
  240. Y. J. R. Menezo, B. Nicollet, J. Rollet, and A. Hazout, “Pregnancy and delivery after in vitro maturation of naked ICSI-GV oocytes with GH and transfer of a frozen thawed blastocyst: case report,” Journal of Assisted Reproduction and Genetics, vol. 23, no. 1, pp. 47–49, 2006. View at Publisher · View at Google Scholar · View at Scopus
  241. Y. J. R. Ménézo, S. El Mouatassim, M. Chavrier, E. J. Servy, and B. Nicolet, “Human oocytes and preimplantation embryos express mRNA for growth hormone receptor,” Zygote, vol. 11, no. 4, pp. 293–297, 2003. View at Publisher · View at Google Scholar · View at Scopus
  242. H. Quesnel, “Localization of binding sites for IGF-I, insulin and GH in the sow ovary,” Journal of Endocrinology, vol. 163, no. 2, pp. 363–372, 1999. View at Publisher · View at Google Scholar · View at Scopus
  243. R. Abir, R. Garor, C. Felz, S. Nitke, H. Krissi, and B. Fisch, “Growth hormone and its receptor in human ovaries from fetuses and adults,” Fertility and Sterility, vol. 90, no. 4, pp. 1333–1339, 2008. View at Publisher · View at Google Scholar · View at Scopus
  244. B. Campbell, J. Dickey, B. Beckman et al., “Previtellogenic oocyte growth in salmon: relationships among body growth, plasma insulin-like growth factor-1, estradiol-17beta, follicle-stimulating hormone and expression of ovarian genes for insulin-like growth factors, steroidogenic-acute regulatory protein and receptors for gonadotropins, growth hormone, and somatolactin,” Biology of Reproduction, vol. 75, no. 1, pp. 34–44, 2006. View at Publisher · View at Google Scholar · View at Scopus
  245. G. Zhu, S. Liu, Y. Jiang, H. Yang, and J. Li, “Growth hormone pathway gene expression varies in porcine cumulus-oocyte complexes during in vitro maturation,” In Vitro Cellular and Developmental Biology—Animal, vol. 44, no. 8-9, pp. 305–308, 2008. View at Publisher · View at Google Scholar · View at Scopus
  246. S. Kölle, F. Sinowatz, G. Boie, and D. Lincoln, “Developmental changes in the expression of the growth hormone receptor messenger ribonucleic acid and protein in the bovine ovary,” Biology of Reproduction, vol. 59, no. 4, pp. 836–842, 1998. View at Publisher · View at Google Scholar · View at Scopus
  247. R. L. Krisher, “The effect of oocyte quality on development,” Journal of Animal Science, vol. 82, no. 13, pp. E14–E23, 2004. View at Google Scholar · View at Scopus
  248. G. R. Pereira, P. L. Lorenzo, G. F. Carneiro et al., “The involvement of growth hormone in equine oocyte maturation, receptor localization and steroid production by cumulus-oocyte complexes in vitro,” Research in Veterinary Science, vol. 95, no. 2, pp. 667–674, 2013. View at Publisher · View at Google Scholar · View at Scopus
  249. R. N. Kirkwood, P. A. Thacker, A. D. Gooneratne et al., “The influence of exogenous growth hormone on ovulation rate in gilts,” Canadian Journal of Animal Science, vol. 68, no. 4, pp. 1097–1103, 1988. View at Google Scholar
  250. C. J. Andres, M. L. Green, J. A. Clapper, T. R. Cline, and M. A. Diekman, “Influence of daily injections of porcine somatotropin on growth, puberty, and reproduction in gilts,” Journal of Animal Science, vol. 69, no. 9, pp. 3754–3761, 1991. View at Google Scholar · View at Scopus
  251. J. Folch, J. P. Ramón, M. J. Cocero, J. L. Alabart, and J. F. Beckers, “Exogenous growth hormone improves the number of transferable embryos in superovulated ewes,” Theriogenology, vol. 55, no. 9, pp. 1777–1785, 2001. View at Publisher · View at Google Scholar · View at Scopus
  252. A. Montero-Pardo, J. Hernández-Cerón, S. Rojas-Maya, J. Valencia, A. Rodríguez-Cortez, and C. G. Gutiérrez, “Increased cleavage and blastocyst rate in ewes treated with bovine somatotropin 5 days before the end of progestin-based estrous synchronization,” Animal Reproduction Science, vol. 125, no. 1–4, pp. 69–73, 2011. View at Publisher · View at Google Scholar · View at Scopus
  253. W. Yuan and M. C. Lucy, “Messenger ribonucleic acid expression for growth hormone receptor, luteinizing hormone receptor, and steroidogenic enzymes during the estrous cycle and pregnancy in porcine and bovine corpora lutea,” Domestic Animal Endocrinology, vol. 13, no. 5, pp. 431–444, 1996. View at Publisher · View at Google Scholar · View at Scopus
  254. P. Ovesen, H. J. Ingerslev, H. Orskov, and T. Ledet, “Effect of growth hormone on steroidogenesis, insulin-like growth factor-I (IGF-I) and IGF-binding protein-1 production and DNA synthesis in cultured human luteinized granulosa cells,” Journal of Endocrinology, vol. 140, no. 2, pp. 313–319, 1994. View at Publisher · View at Google Scholar · View at Scopus
  255. M. L. Rhoads, J. P. Meyer, S. J. Kolath, W. R. Lamberson, and M. C. Lucy, “Growth hormone receptor, insulin-like growth factor (IGF)-1, and IGF-binding protein-2 expression in the reproductive tissues of early post part urn dairy cows,” Journal of Dairy Science, vol. 91, no. 5, pp. 1802–1813, 2008. View at Publisher · View at Google Scholar · View at Scopus
  256. M. C. Lucy, C. R. Bilby, C. J. Kirby, W. Yuan, and C. K. Boyd, “Role of growth hormone in development and maintenance of follicles and corpora lutea,” Journal of Reproduction & Infertility, vol. 54, pp. 49–59, 1999. View at Google Scholar · View at Scopus
  257. F. Jimenez-Krassel, M. Binelli, H. A. Tucker, and J. J. Ireland, “Effect of long-term infusion with recombinant growth hormone-releasing factor and recombinant bovine somatotropin on development and function of dominant follicles and corpora lutea in Holstein cows,” Journal of Dairy Science, vol. 82, no. 9, pp. 1917–1926, 1999. View at Publisher · View at Google Scholar · View at Scopus
  258. B. Berisha and D. Schams, “Ovarian function in ruminants,” Domestic Animal Endocrinology, vol. 29, no. 2, pp. 305–317, 2005. View at Publisher · View at Google Scholar · View at Scopus
  259. D. Schams and B. Berisha, “Regulation of corpus luteum function in cattle—an overview,” Reproduction in Domestic Animals, vol. 39, no. 4, pp. 241–251, 2004. View at Publisher · View at Google Scholar · View at Scopus
  260. W. W. Thatcher, A. Guzeloglu, R. Mattos, M. Binelli, T. R. Hansen, and J. K. Pru, “Uterine-conceptus interactions and reproductive failure in cattle,” Theriogenology, vol. 56, no. 9, pp. 1435–1450, 2001. View at Publisher · View at Google Scholar · View at Scopus
  261. T. R. Bilby, A. Sozzi, M. M. Lopez et al., “Pregnancy, bovine somatotropin, and dietary n-3 fatty acids in lactating dairy cows: I. Ovarian, conceptus, and growth hormone-insulin-like growth factor system responses,” Journal of Dairy Science, vol. 89, no. 9, pp. 3360–3374, 2006. View at Publisher · View at Google Scholar · View at Scopus
  262. S. Kobayashi, A. Miyamoto, B. Berisha, and D. Schams, “Growth hormone, but not luteinizing hormone, acts with luteal peptides on prostaglandin F2α and progesterone secretion by bovine corpora lutea in vitro,” Prostaglandins and Other Lipid Mediators, vol. 63, no. 3, pp. 79–92, 2001. View at Publisher · View at Google Scholar · View at Scopus
  263. E. J. Owen, C. West, B. A. Mason, and H. S. Jacobs, “Co-treatment with growth hormone of sub-optimal responders in IVF-ET,” Human Reproduction, vol. 6, no. 4, pp. 524–528, 1991. View at Google Scholar · View at Scopus
  264. R. Homburg, A. Eshel, H. I. Abdalla, and H. S. Jacobs, “Growth hormone facilitates ovulation induction by gonadotrophins,” Clinical Endocrinology, vol. 29, no. 1, pp. 113–117, 1988. View at Publisher · View at Google Scholar · View at Scopus
  265. D. de Ziegler, I. Streuli, D. R. Meldrum, and C. Chapron, “The value of growth hormone supplements in ART for poor ovarian responders,” Fertility and Sterility, vol. 96, no. 5, pp. 1069–1076, 2011. View at Publisher · View at Google Scholar · View at Scopus
  266. A. P. Ferraretti, A. La Marca, B. C. J. M. Fauser, B. Tarlatzis, G. Nargund, and L. Gianaroli, “ESHRE consensus on the definition of “poor response” to ovarian stimulation for in vitro fertilization: the Bologna criteria,” Human Reproduction, vol. 26, no. 7, pp. 1616–1624, 2011. View at Publisher · View at Google Scholar · View at Scopus
  267. D. Nikolaou, S. Lavery, C. Turner, R. Margara, and G. Trew, “Is there a link between an extremely poor response to ovarian hyperstimulation and early ovarian failure?” Human Reproduction, vol. 17, no. 4, pp. 1106–1111, 2002. View at Publisher · View at Google Scholar · View at Scopus
  268. B. C. Tarlatzis, L. Zepiridis, G. Grimbizis, and J. Bontis, “Clinical management of low ovarian response to stimulation for IVF: a systematic review,” Human Reproduction Update, vol. 9, no. 1, pp. 61–76, 2003. View at Publisher · View at Google Scholar · View at Scopus
  269. E. M. Kolibianakis, C. A. Venetis, K. Diedrich, B. C. Tarlatzis, and G. Griesinger, “Addition of growth hormone to gonadotrophins in ovarian stimulation of poor responders treated by in-vitro fertilization: a systematic review and meta-analysis,” Human Reproduction Update, vol. 15, no. 6, pp. 613–622, 2009. View at Publisher · View at Google Scholar · View at Scopus
  270. R. Homburg, A. Singh, P. Bhide, A. Shah, and A. Gudi, “The re-growth of growth hormone in fertility treatment: a critical review,” Human Fertility, vol. 15, no. 4, pp. 190–193, 2012. View at Publisher · View at Google Scholar · View at Scopus
  271. J. M. Duffy, G. Ahmad, L. Mohiyiddeen, L. G. Nardo, and A. Watson, “Growth hormone for in vitro fertilization,” Cochrane Database of Systematic Reviews, no. 1, Article ID CD000099, 2010. View at Google Scholar · View at Scopus
  272. D. Kyrou, E. M. Kolibianakis, C. A. Venetis, E. G. Papanikolaou, J. Bontis, and B. C. Tarlatzis, “How to improve the probability of pregnancy in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis,” Fertility and Sterility, vol. 91, no. 3, pp. 749–766, 2009. View at Publisher · View at Google Scholar · View at Scopus
  273. T. Kucuk, H. Kozinoglu, and A. Kaba, “Growth hormone co-treatment within a GnRH agonist long protocol in patients with poor ovarian response: a prospective, randomized, clinical trial,” Journal of Assisted Reproduction and Genetics, vol. 25, no. 4, pp. 123–127, 2008. View at Publisher · View at Google Scholar · View at Scopus
  274. A. Hazout, A. M. Junca, Y. Ménézo, J. de Mouzon, and P. Cohen-Bacrie, “Effect of growth hormone on oocyte competence in patients with multiple IVF failures,” Reproductive BioMedicine Online, vol. 18, no. 5, pp. 664–670, 2009. View at Publisher · View at Google Scholar · View at Scopus
  275. J. Tesarik, A. Hazout, and C. Mendoza, “Improvement of delivery and live birth rates after ICSI in women aged >40 years by ovarian co-stimulation with growth hormone,” Human Reproduction, vol. 20, no. 9, pp. 2536–2541, 2005. View at Publisher · View at Google Scholar · View at Scopus
  276. B. E. Spiliotis, “Growth hormone insufficiency and its impact on ovarian function,” Annals of the New York Academy of Sciences, vol. 997, pp. 77–84, 2003. View at Publisher · View at Google Scholar · View at Scopus
  277. H. Rajesh, Y. Y. Yong, M. Zhu, D. Chia, and S. L. Yu, “Growth hormone deficiency and supplementation at in-vitro fertilisation,” Singapore Medical Journal, vol. 48, no. 6, pp. 514–518, 2007. View at Google Scholar · View at Scopus
  278. N. E. Kokshoorn, N. R. Biermasz, F. Roelfsema, J. W. A. Smit, A. M. Pereira, and J. A. Romijn, “GH replacement therapy in elderly GH-deficient patients: a systematic review,” European Journal of Endocrinology, vol. 164, no. 5, pp. 657–665, 2011. View at Publisher · View at Google Scholar · View at Scopus
  279. C. Díaz-García, C. Estella, A. Perales-Puchalt, and C. Simón, “Reproductive medicine and inheritance of infertility by offspring: the role of fetal programming,” Fertility and Sterility, vol. 96, no. 3, pp. 536–545, 2011. View at Publisher · View at Google Scholar · View at Scopus
  280. A. P. A. Van Montfoort, L. L. P. Hanssen, P. De Sutter, S. Viville, J. P. M. Geraedts, and P. De Boer, “Assisted reproduction treatment and epigenetic inheritance,” Human Reproduction Update, vol. 18, no. 2, Article ID dmr047, pp. 171–197, 2012. View at Publisher · View at Google Scholar · View at Scopus
  281. P. E. Lobie, J. García-Aragón, B. S. Wang, W. R. Baumbach, and M. J. Waters, “Cellular localization of the growth hormone binding protein in the rat,” Endocrinology, vol. 130, no. 5, pp. 3057–3065, 1992. View at Google Scholar · View at Scopus
  282. X.-D. Zi, X.-K. Mu, and Y. Wang, “Variation in sequences and mRNA expression levels of growth hormone (GH), insulin-like growth factor I (IGF-I) and II (IGF-II) genes between prolific Lezhi black goat and non-prolific Tibetan goat (Capra hircus),” General and Comparative Endocrinology, vol. 187, pp. 1–5, 2013. View at Publisher · View at Google Scholar · View at Scopus
  283. F. Izadyar, J. Zhao, H. T. van Tol et al., “Messenger RNA expression and protein localization of growth hormone in bovine ovarian tissue and in cumulus oocyte complexes (COCs) during in vitro maturation,” Molecular Reproduction and Development, vol. 53, no. 4, pp. 398–406, 1999. View at Google Scholar
  284. A. Hrabia, H. E. Paczoska-Eliasiewicz, L. R. Berghman, S. Harvey, and J. Rza̧sa, “Expression and localization of growth hormone and its receptors in the chicken ovary during sexual maturation,” Cell and Tissue Research, vol. 332, no. 2, pp. 317–328, 2008. View at Publisher · View at Google Scholar · View at Scopus
  285. P. Schwärzler, G. Untergasser, M. Hermann et al., “Selective growth hormone/placental lactogen gene transcription and hormone production in pre- and postmenopausal human ovaries,” The Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 10, pp. 3337–3341, 1997. View at Publisher · View at Google Scholar · View at Scopus
  286. J. Zhao, M. A. M. Taverne, G. C. van der Weijden, M. M. Bevers, and R. van den Hurk, “Immunohistochemical localisation of growth hormone (GH), GH receptor (GHR), insulin-like growth factor I (IGF-I) and type IIGF-I receptor, and gene expression of GH and GHR in rat pre-antral follicles,” Zygote, vol. 10, no. 1, pp. 85–94, 2002. View at Publisher · View at Google Scholar · View at Scopus
  287. S. Modina, V. Borromeo, A. M. Luciano, V. Lodde, F. Franciosi, and C. Secchi, “Relationship between growth hormone concentrations in bovine oocytes and follicular fluid and oocyte developmental competence,” European Journal of Histochemistry, vol. 51, no. 3, pp. 173–180, 2007. View at Google Scholar · View at Scopus
  288. C. Mendoza, E. Ruiz-Requena, E. Ortega et al., “Follicular fluid markers of oocyte developmental potential,” Human Reproduction, vol. 17, no. 4, pp. 1017–1022, 2002. View at Publisher · View at Google Scholar · View at Scopus
  289. O. Khorram, M. Garthwaite, E. Grosen, and T. Golos, “Human uterine and ovarian expression of growth hormone-releasing hormone messenger RNA in benign and malignant gynecologic conditions,” Fertility and Sterility, vol. 75, no. 1, pp. 174–179, 2001. View at Publisher · View at Google Scholar · View at Scopus
  290. C. Moretti, A. Bagnato, N. Solan, G. Frajese, and K. J. Catt, “Receptor-mediated actions of growth hormone releasing factor on granulosa cell differentiation,” Endocrinology, vol. 127, no. 5, pp. 2117–2126, 1990. View at Publisher · View at Google Scholar · View at Scopus
  291. A. Bagnato, C. Moretti, J. Ohnishi, G. Frajese, and K. J. Catt, “Expression of the growth hormone-releasing hormone gene and its peptide product in the rat ovary,” Endocrinology, vol. 130, no. 3, pp. 1097–1102, 1992. View at Publisher · View at Google Scholar · View at Scopus
  292. T. E. Porter, L. E. Ellestad, A. Fay, J. L. Stewart, and I. Bossis, “Identification of the chicken growth hormone-releasing hormone receptor (GHRH-R) mRNA and gene: regulation of anterior pituitary GHRH-R mRNA levels by homologous and heterologous hormones,” Endocrinology, vol. 147, no. 5, pp. 2535–2543, 2006. View at Publisher · View at Google Scholar · View at Scopus
  293. A. Rak and E. Ł. Gregoraszczuk, “Local feedback loop of ghrelin-GH in the pig ovary: action on estradiol secretion, aromatase activity and cell apoptosis,” Growth Hormone & IGF Research, vol. 18, no. 3, pp. 221–227, 2008. View at Publisher · View at Google Scholar · View at Scopus
  294. A. Rak, D. Szczepankiewicz, and E. Ł. Gregoraszczuk, “Expression of ghrelin receptor, GHSR-1a, and its functional role in the porcine ovarian follicles,” Growth Hormone and IGF Research, vol. 19, no. 1, pp. 68–76, 2009. View at Publisher · View at Google Scholar · View at Scopus
  295. A. V. Sirotkin, R. Grossmann, M. T. María-Peon, J. Roa, M. Tena-Sempere, and S. Klein, “Novel expression and functional role of ghrelin in chicken ovary,” Molecular and Cellular Endocrinology, vol. 257-258, pp. 15–25, 2006. View at Publisher · View at Google Scholar · View at Scopus
  296. F. I. Sharara and L. K. Nieman, “Identification and cellular localization of growth hormone receptor gene expression in the human ovary,” The Journal of Clinical Endocrinology & Metabolism, vol. 79, no. 2, pp. 670–672, 1994. View at Publisher · View at Google Scholar · View at Scopus
  297. B. Carlsson, A. Nilsson, O. G. P. Isaksson, and H. Billig, “Growth hormone-receptor messenger RNA in the rat ovary: regulation and localization,” Molecular and Cellular Endocrinology, vol. 95, no. 1-2, pp. 59–66, 1993. View at Publisher · View at Google Scholar · View at Scopus
  298. T. Shimizu, C. Murayama, N. Sudo, C. Kawashima, M. Tetsuka, and A. Miyamoto, “Involvement of insulin and growth hormone (GH) during follicular development in the bovine ovary,” Animal Reproduction Science, vol. 106, no. 1-2, pp. 143–152, 2008. View at Publisher · View at Google Scholar · View at Scopus
  299. A. Ptak, M. Kajta, and E. L. Gregoraszczuk, “Effect of growth hormone and insulin-like growth factor-I on spontaneous apoptosis in cultured luteal cells collected from early, mature, and regressing porcine corpora lutea,” Animal Reproduction Science, vol. 80, no. 3-4, pp. 267–279, 2004. View at Publisher · View at Google Scholar · View at Scopus
  300. R. Apa, A. Lanzone, F. Miceli, A. Caruso, S. Mancuso, and R. Canipari, “Growth hormone induction of rat granulosa cell tissue-plasminogen activator expression and progesterone synthesis,” Molecular and Cellular Endocrinology, vol. 99, no. 2, pp. 153–159, 1994. View at Publisher · View at Google Scholar · View at Scopus
  301. C.-J. Hsu and J. M. Hammond, “Gonadotropins and estradiol stimulate immunoreactive insulin-like growth factor-I production by porcine granulosa cells in vitro,” Endocrinology, vol. 120, no. 1, pp. 198–207, 1987. View at Publisher · View at Google Scholar · View at Scopus
  302. F. Izadyar, H. T. van Tol, B. Colenbrander, and M. M. Bevers, “Stimulatory effect of growth hormone on in vitro maturation of bovine oocytes is exerted through cumulus cells and not mediated by IGF-I,” Molecular Reproduction and Development, vol. 47, no. 2, pp. 175–180, 1997. View at Google Scholar
  303. A. Barreca, P. G. Artini, P. Del Monte et al., “In vivo and in vitro effect of growth hormone on estradiol secretion by human granulosa cells,” The Journal of Clinical Endocrinology & Metabolism, vol. 77, no. 1, pp. 61–67, 1993. View at Publisher · View at Google Scholar · View at Scopus
  304. P. Lonergan, A. Woods, T. Fair et al., “Effect of embryo source and recipient progesterone environment on embryo development in cattle,” Reproduction, Fertility and Development, vol. 19, no. 7, pp. 861–868, 2007. View at Publisher · View at Google Scholar · View at Scopus
  305. A. M. Murphy, K. G. Meade, P. A. Hayes et al., “Transmission ratio distortion at the growth hormone gene (GH1) in bovine preimplantation embryos: an in vitro culture-induced phenomenon?” Molecular Reproduction and Development, vol. 75, no. 5, pp. 715–722, 2008. View at Publisher · View at Google Scholar · View at Scopus
  306. M. Pantaleon, E. J. Whiteside, M. B. Harvey, R. T. Barnard, M. J. Waters, and P. L. Kaye, “Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis?” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 10, pp. 5125–5130, 1997. View at Publisher · View at Google Scholar · View at Scopus
  307. F. Izadyar, H. T. van Tol, W. G. Hage, and M. M. Bevers, “Preimplantation bovine embryos express mRNA of growth hormone receptor and respond to growth hormone addition during in vitro development,” Molecular Reproduction and Development, vol. 57, no. 3, pp. 247–255, 2000. View at Google Scholar
  308. T. Fukaya, T. Yamanaka, Y. Terada, T. Murakami, and A. Yajima, “Growth hormone improves mouse embryo development in vitro, and the effect is neutralized by growth hormone receptor antibody,” Tohoku Journal of Experimental Medicine, vol. 184, no. 2, pp. 113–122, 1998. View at Publisher · View at Google Scholar · View at Scopus
  309. K. E. Markham and P. L. Kaye, “Growth hormone, insulin-like growth factor I and cell proliferation in the mouse blastocyst,” Reproduction, vol. 125, no. 3, pp. 327–336, 2003. View at Publisher · View at Google Scholar · View at Scopus
  310. A. Kidson, F. J. Rubio-Pomar, A. van Knegsel et al., “Quality of porcine blastocysts produced in vitro in the presence or absence of GH,” Reproduction, vol. 127, no. 2, pp. 165–177, 2004. View at Publisher · View at Google Scholar · View at Scopus
  311. E. M. Joudrey, D. Lechniak, J. Petrik, and W. A. King, “Expression of growth hormone and its transcription factor, Pit-1, in early bovine development,” Molecular Reproduction and Development, vol. 64, no. 3, pp. 275–283, 2003. View at Publisher · View at Google Scholar · View at Scopus
  312. S. Kölle, M. Stojkovic, G. Boie, E. Wolf, and F. Sinowatz, “Growth hormone inhibits apoptosis in in vitro produced bovine embryos,” Molecular Reproduction and Development, vol. 61, no. 2, pp. 180–186, 2002. View at Publisher · View at Google Scholar · View at Scopus
  313. M. Montag, B. Koll, P. Holmes, and H. van der Ven, “Significance of the number of embryonic cells and the state of the zona pellucida for hatching of mouse blastocysts in vitro versus in vivo,” Biology of Reproduction, vol. 62, no. 6, pp. 1738–1744, 2000. View at Publisher · View at Google Scholar · View at Scopus
  314. P. Drakakis, D. Loutradis, S. Milingos et al., “A preliminary study of the effect of growth hormone on mouse preimplantation embryo development in vitro,” Gynecologic and Obstetric Investigation, vol. 40, no. 4, pp. 222–226, 1995. View at Publisher · View at Google Scholar · View at Scopus
  315. B. J. L. Thompson, C. A. Shang, and M. J. Waters, “Identification of genes induced by growth hormone in rat liver using cDNA arrays,” Endocrinology, vol. 141, no. 11, pp. 4321–4324, 2000. View at Publisher · View at Google Scholar · View at Scopus
  316. M.-C. Lacroix, J. Guibourdenche, T. Fournier et al., “Stimulation of human trophoblast invasion by placental growth hormone,” Endocrinology, vol. 146, no. 5, pp. 2434–2444, 2005. View at Publisher · View at Google Scholar · View at Scopus
  317. B. A. Costine, E. K. Inskeep, and M. E. Wilson, “Growth hormone at breeding modifies conceptus development and postnatal growth in sheep,” Journal of Animal Science, vol. 83, no. 4, pp. 810–815, 2005. View at Google Scholar · View at Scopus
  318. S. Noel, A. Herman, G. A. Johnson et al., “Ovine placental lactogen specifically binds to endometrial glands of the ovine uterus,” Biology of Reproduction, vol. 68, no. 3, pp. 772–780, 2003. View at Publisher · View at Google Scholar · View at Scopus
  319. C. Rehfeldt, P. M. Nissen, G. Kuhn, M. Vestergaard, K. Ender, and N. Oksbjerg, “Effects of maternal nutrition and porcine growth hormone (pGH) treatment during gestation on endocrine and metabolic factors in sows, fetuses and pigs, skeletal muscle development, and postnatal growth,” Domestic Animal Endocrinology, vol. 27, no. 3, pp. 267–285, 2004. View at Publisher · View at Google Scholar · View at Scopus
  320. S. Kölle, M. Stojkovic, K. Prelle, M. Waters, E. Wolf, and F. Sinowatz, “Growth hormone (GH)/GH receptor expression and GH-mediated effects during early bovine embryogenesis,” Biology of Reproduction, vol. 64, no. 6, pp. 1826–1834, 2001. View at Google Scholar
  321. S. Kölle, M. Stojkovic, S. Reese, H.-D. Reichenbach, E. Wolf, and F. Sinowatz, “Effects of growth hormone on the ultrastructure of bovine preimplantation embryos,” Cell and Tissue Research, vol. 317, no. 1, pp. 101–108, 2004. View at Google Scholar · View at Scopus
  322. H. Iwata, M. Ohota, S. Hashimoto, K. Kimura, M. Isaji, and M. Miyake, “Stage-specific effect of growth hormone on developmental competence of bovine embryos produced in-vitro,” Journal of Reproduction and Development, vol. 49, no. 6, pp. 493–499, 2003. View at Publisher · View at Google Scholar · View at Scopus
  323. E. Gootwine, “Placental hormones and fetal-placental development,” Animal Reproduction Science, vol. 82-83, pp. 551–566, 2004. View at Publisher · View at Google Scholar · View at Scopus
  324. M. J. Soares, “The prolactin and growth hormone families: pregnancy-specific hormones/cytokines at the maternal-fetal interface,” Reproductive Biology and Endocrinology, vol. 2, article 51, 2004. View at Publisher · View at Google Scholar · View at Scopus
  325. J. Fuglsang and P. Ovesen, “Aspects of placental growth hormone physiology,” Growth Hormone and IGF Research, vol. 16, no. 2, pp. 67–85, 2006. View at Publisher · View at Google Scholar · View at Scopus
  326. D. Haig, “Placental growth hormone-related proteins and prolactin-related proteins,” Placenta, vol. 29, pp. S36–S41, 2008. View at Publisher · View at Google Scholar · View at Scopus
  327. J. Verhaeghe, “Does the physiological acromegaly of pregnancy benefit the fetus?” Gynecologic and Obstetric Investigation, vol. 66, no. 4, pp. 217–226, 2008. View at Publisher · View at Google Scholar · View at Scopus
  328. Y. Jin, S. Y. Lu, A. Fresnoza, K. A. Detillieux, M. L. Duckworth, and P. A. Cattini, “Differential placental hormone gene expression during pregnancy in a transgenic mouse containing the human growth hormone/chorionic somatomammotropin locus,” Placenta, vol. 30, no. 3, pp. 226–235, 2009. View at Publisher · View at Google Scholar · View at Scopus
  329. M. Sbracia, F. Scarpellini, R. Poverini, P. L. Alò, G. Rossi, and U. Di Tondo, “Immunohistochemical localization of the growth hormone in human endometrium and decidua,” American Journal of Reproductive Immunology, vol. 51, no. 2, pp. 112–116, 2004. View at Publisher · View at Google Scholar · View at Scopus
  330. C. Sosa, M. Carriquiry, C. Chalar et al., “Endometrial expression of leptin receptor and members of the growth hormone-Insulin-like growth factor system throughout the estrous cycle in heifers,” Animal Reproduction Science, vol. 122, no. 3-4, pp. 208–214, 2010. View at Publisher · View at Google Scholar · View at Scopus
  331. C. R. P. Oliveira, R. Salvatori, L. M. A. Nóbrega et al., “Sizes of abdominal organs in adults with severe short stature due to severe, untreated, congenital GH deficiency caused by a homozygous mutation in the GHRH receptor gene,” Clinical Endocrinology, vol. 69, no. 1, pp. 153–158, 2008. View at Publisher · View at Google Scholar · View at Scopus
  332. D. Stygar, N. Muravitskaya, B. Eriksson, H. Eriksson, and L. Sahlin, “Effects of SERM (selective estrogen receptor modulator) treatment on growth and proliferation in the rat uterus,” Reproductive Biology and Endocrinology, vol. 1, article 40, 2003. View at Publisher · View at Google Scholar · View at Scopus
  333. S. F. M. Bhatti, N. A. S. Rao, A. C. Okkens et al., “Role of progestin-induced mammary-derived growth hormone in the pathogenesis of cystic endometrial hyperplasia in the bitch,” Domestic Animal Endocrinology, vol. 33, no. 3, pp. 294–312, 2007. View at Publisher · View at Google Scholar · View at Scopus
  334. H. S. Kooistra, A. C. Okkens, J. A. Mol, E. van Garderen, J. Kirpensteijn, and A. Rijnberk, “Lack of association of progestin-induced cystic endometrial hyperplasia with GH gene expression in the canine uterus,” Journal of Reproduction and Fertility, vol. 51, pp. 355–361, 1997. View at Google Scholar · View at Scopus
  335. Z.-S. Wu, K. Yang, Y. Wan et al., “Tumor expression of human growth hormone and human prolactin predict a worse survival outcome in patients with mammary or endometrial carcinoma,” The Journal of Clinical Endocrinology & Metabolism, vol. 96, no. 10, pp. E1619–E1629, 2011. View at Publisher · View at Google Scholar · View at Scopus
  336. V. Pandey, J. K. Perry, K. M. Mohankumar et al., “Autocrine human growth hormone stimulates oncogenicity of endometrial carcinoma cells,” Endocrinology, vol. 149, no. 8, pp. 3909–3919, 2008. View at Publisher · View at Google Scholar · View at Scopus
  337. B. L. Conway-Campbell, W. W. Jong, A. J. Brooks et al., “Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 33, pp. 13331–13336, 2007. View at Publisher · View at Google Scholar · View at Scopus
  338. R. Dehari, Y. Nakamura, N. Okamoto, and H. Nakayama, “Increased nuclear expression of growth hormone receptor in uterine cervical neoplasms of women under 40 years old,” The Tohoku Journal of Experimental Medicine, vol. 216, no. 2, pp. 165–172, 2008. View at Publisher · View at Google Scholar · View at Scopus
  339. I. Chatzistamou, A. V. Schally, H. Kiaris et al., “Immunohistochemical detection of GHRH and its receptor splice variant 1 in primary human breast cancers,” European Journal of Endocrinology, vol. 151, no. 3, pp. 391–396, 2004. View at Publisher · View at Google Scholar · View at Scopus
  340. J. B. Engel, G. Keller, A. V. Schally et al., “Inhibition of growth of experimental human endometrial cancer by an antagonist of growth hormone-releasing hormone,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 6, pp. 3614–3621, 2005. View at Publisher · View at Google Scholar · View at Scopus
  341. L. Zhao, T. Yano, Y. Osuga et al., “Cellular mechanisms of growth inhibition of human endometrial cancer cell line by an antagonist of growth hormone-releasing hormone,” International Journal of Oncology, vol. 32, no. 3, pp. 593–601, 2008. View at Google Scholar · View at Scopus