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International Journal of Endocrinology
Volume 2014, Article ID 265954, 10 pages
Review Article

Growth Abnormalities in Children with Type 1 Diabetes, Juvenile Chronic Arthritis, and Asthma

1Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini 5, 66100-Chieti, Italy
2Center of Excellence on Aging, “G. D’Annunzio” University Foundation, University of Chieti, Via dei Vestini 5, 66100-Chieti, Italy

Received 26 September 2013; Accepted 12 December 2013; Published 4 February 2014

Academic Editor: Kevin Sinchak

Copyright © 2014 Cosimo Giannini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Children and adolescents with chronic diseases are commonly affected by a variable degree of growth failure, leading to an impaired final height. Of note, the peculiar onset during childhood and adolescence of some chronic diseases, such as type 1 diabetes, juvenile idiopathic arthritis, and asthma, underlines the relevant role of healthcare planners and providers in detecting and preventing growth abnormalities in these high risk populations. In this review article, the most relevant common and disease-specific mechanisms by which these major chronic diseases affect growth in youth are analyzed. In addition, the available and potential targeting strategies to restore the physiological, hormonal, and inflammatory pattern are described.