International Journal of Endocrinology / 2014 / Article / Tab 2

Research Article

Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid

Table 2

Clinicopathologic features and the NRAS mutation status of 60 thyroid cancers with a preoperative diagnosis of follicular neoplasm.

Patients with a NRAS negative thyroid cancer
Patients with a NRAS positive thyroid cancer
-value

Average tumor size (cm)2.2 ± 1.41.4 ± 0.90.012
Age
45 years17 (59%)12 (41%)0.464
 >45 years21 (68%)10 (32%)
Gender
 Female26 (62%)16 (38%)0.726
 Male12 (67%)6 (33%)
Histopathology
 Encapsulated FVPTC19 (51%)18 (49%)
 Infiltrative FVPTC4 (67%)2 (33%)
 Classic PTC3 (100%)0
 FTC11 (85%)2 (15%)
 Poorly differentiated1 (100%)0
Capsular invasion
 Negative13 (50%)13 (50%)0.061
 Positive25 (74%)9 (26%)
Vascular invasion
 Negative31 (61%)20 (39%)0.329
 Positive7 (78%)2 (22%)
Lymph node metastasis
 Negative25 (66%)13 (34%)0.400
 Positive4 (50%)4 (50%)

FVPTC, follicular variant of papillary thyroid carcinoma; PTC, papillary thyroid carcinoma; FTC, follicular thyroid carcinoma.