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International Journal of Endocrinology
Volume 2014, Article ID 308017, 7 pages
Research Article

Thermogenic Effect of Glucose in Hypothyroid Subjects

1Mossakowski Medical Research Center, Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland
2Masovian Hospital Bródno, 8 Kondratowicza Street, 03-242 Warsaw, Poland

Received 22 November 2013; Revised 3 February 2014; Accepted 3 February 2014; Published 10 March 2014

Academic Editor: Amelie Bonnefond

Copyright © 2014 Agnieszka Kozacz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The importance of thyroid hormone, catecholamines, and insulin in modification of the thermogenic effect of glucose (TEG) was examined in 34 healthy and 32 hypothyroid subjects. We calculated the energy expenditure at rest and during oral glucose tolerance test. Blood samples for determinations of glucose, plasma insulin, adrenaline (A), and noradrenaline (NA) were collected. It was found that TEG was lower in hypothyroid than in control group ( versus  kJ, resp., ). Mean values of glucose and insulin areas under the curve were higher in women with hypothyroidism than in control group ( versus  mmol/L·min, and versus  mU/L·min, resp.). Maximal levels of catecholamines after glucose ingestion were higher in hypothyroid patients than in control subjects (Amax— versus  nmol/L, , and NAmax— versus  nmol/L, ). It can be concluded that in hypothyroidism TEG and glucose tolerance are decreased while the adrenergic response to glucose administration is enhanced. Presumably, these changes are related to decreased insulin sensitivity and responsiveness to catecholamine action.