Effect of Bile Acid on Fetal Lung in Rat Model of Intrahepatic Cholestasis of Pregnancy
The morphology of fetal rat lungs in electronic microscope. (a) The high bile acid group: type II alveolar epithelial cells with swelling mitochondria were degenerated. Lamellar body had disappeared. A large number of red blood cells, proteins, cell debris falling, and edema fluid were filled in alveolar cavity. 5000 (A1), 12000 (A2). (b) The low bile acid group: type II alveolar epithelial cells with decreasing microvilli on the surfaces and slight swelling mitochondria were observed. 5000 (B1), 12000 (B2). (c) The experimental control group: type II alveolar epithelial cells were in good condition. A clear lamellar structure can be observed in lamellar bodies. 5000 (C1), 12000 (C2). Arrow A: swelled mitochondria (balloon-like); arrow B: lamellar body.