Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2014, Article ID 372021, 5 pages
http://dx.doi.org/10.1155/2014/372021
Clinical Study

Hip Osteoarthritis and Osteoporosis: Clinical and Histomorphometric Considerations

1Department of Orthopaedics and Traumatology, University of Rome “Tor Vergata”, Viale Oxford 81, 00133 Rome, Italy
2Department of Anatomic Pathology, University of Rome “Tor Vergata”, Viale Oxford 81, 00133 Rome, Italy

Received 24 November 2013; Revised 24 January 2014; Accepted 15 March 2014; Published 14 April 2014

Academic Editor: Nicola Napoli

Copyright © 2014 Umberto Tarantino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. O. Johnell and J. A. Kanis, “An estimate of the worldwide prevalence and disability associated with osteoporotic fractures,” Osteoporosis International, vol. 17, no. 12, pp. 1726–1733, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. K. E. Covinsky, A. W. Wu, C. S. Landefeld et al., “Health status versus quality of life in older patients: does the distinction matter?” The American Journal of Medicine, vol. 106, no. 4, pp. 435–440, 1999. View at Publisher · View at Google Scholar · View at Scopus
  3. U. Tarantino, G. Cannata, D. Lecce, M. Celi, I. Cerocchi, and R. Iundusi, “Incidence of fragility fractures,” Aging Clinical and Experimental Research, vol. 19, no. 4, pp. 7–11, 2007. View at Google Scholar · View at Scopus
  4. M. V. Foss and P. D. Byers, “Bone density, osteoarthrosis of the hip, and fracture of the upper end of the femur,” Annals of the Rheumatic Diseases, vol. 31, no. 4, pp. 259–264, 1972. View at Google Scholar · View at Scopus
  5. H. Pogrund, M. Rutenberg, and M. Makin, “Osteoarthritis of the hip joint and osteoporosis: a radiological study in a random population sample in Jerusalem,” Clinical Orthopaedics and Related Research, vol. 164, pp. 130–135, 1982. View at Google Scholar · View at Scopus
  6. A. Verstraeten, H. van Ermen, G. Haghebaert, J. Nijs, P. Geusens, and J. Dequeker, “Osteoarthrosis retards the development of osteoporosis: observation of the coexistence of osteoarthrosis and osteoporosis,” Clinical Orthopaedics and Related Research, no. 264, pp. 169–177, 1991. View at Google Scholar · View at Scopus
  7. J. Dequeker and O. Johnell, “Osteoarthritis protects against femoral neck fracture: the MEDOS study experience,” Bone, vol. 14, supplement 1, pp. S51–S56, 1993. View at Google Scholar · View at Scopus
  8. A. Klibanski, L. Adams-Campbell, T. Bassford et al., “Osteoporosis prevention, diagnosis, and therapy,” Journal of the American Medical Association, vol. 285, no. 6, pp. 785–795, 2001. View at Google Scholar · View at Scopus
  9. J. A. Kanis, F. Borgstrom, C. De Laet et al., “Assessment of fracture risk,” Osteoporosis International, vol. 16, no. 6, pp. 581–589, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. M. T. Hannan, J. J. Anderson, Y. Zhang, D. Levy, and D. T. Felson, “Bone mineral density and knee osteoarthritis in elderly men and women: the Framingham Study,” Arthritis and Rheumatism, vol. 36, no. 12, pp. 1671–1680, 1993. View at Publisher · View at Google Scholar · View at Scopus
  11. D. J. Hart, I. Mootoosamy, D. V. Doyle, and T. D. Spector, “The relationship between osteoarthritis and osteoporosis in the general population: the Chingford study,” Annals of the Rheumatic Diseases, vol. 53, no. 3, pp. 158–162, 1994. View at Google Scholar · View at Scopus
  12. M. C. Nevitt, N. E. Lane, J. C. Scott et al., “Radiographic osteoarthritis of the hip and bone mineral density,” Arthritis and Rheumatism, vol. 38, no. 7, pp. 907–916, 1995. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Burger, P. L. A. van Daele, E. Odding et al., “Association of radiographically evident osteoarthritis with higher bone mineral density and increased bone loss with age: the Rotterdam study,” Arthritis and Rheumatism, vol. 39, no. 1, pp. 81–86, 1996. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Sowers, L. Lachance, D. Jamadar et al., “The associations of bone mineral density and bone turnover markers with osteoarthritis of the hand and knee in pre- and perimenopausal women,” Arthritis and Rheumatism, vol. 42, pp. 483–489, 1999. View at Google Scholar
  15. G. R. Jordan, N. Loveridge, J. Power, M. T. Clarke, and J. Reeve, “Increased cancellous bone in the femoral neck of patients with coxarthrosis (hip osteoarthritis): a positive remodeling imbalance favoring bone formation,” Osteoporosis International, vol. 14, no. 2, pp. 160–165, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Shen, Z. M. Zhang, S. D. Jiang, and L. S. Jiang, “Postmenopausal women with osteoarthritis and osteoporosis show different ultrastructural characteristics of trabecular bone of the femoral head,” BMC Musculoskeletal Disorders, vol. 10, article 35, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. C. M. Schnitzler, J. M. Mesquita, and L. Wane, “Bone histomorphometry of the iliac crest, and spinal fracture prevalence in atrophic and hypertrophic osteoarthritis of the hip,” Osteoporosis International, vol. 2, no. 4, pp. 186–194, 1992. View at Publisher · View at Google Scholar · View at Scopus
  18. J. A. de Pedro, A. P. Martin, J. F. Blanco et al., “Histomorphometric study of femoral heads in hip osteoarthritis and osteoporosis,” Histology and Histopathology, vol. 22, no. 10–12, pp. 1091–1097, 2007. View at Google Scholar · View at Scopus
  19. O. Wolf, H. Ström, J. Milbrink, S. Larsson, and H. Mallmin, “Differences in hip bone mineral density may explain the hip fracture pattern in osteoarthritic hips,” Acta orthopaedica, vol. 80, no. 3, pp. 308–313, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Roux, J. Fechtenbaum, K. Briot, C. Cropet, S. Liu-Léage, and C. Marcelli, “Inverse relationship between vertebral fractures and spine osteoarthritis in postmenopausal women with osteoporosis,” Annals of the Rheumatic Diseases, vol. 67, no. 2, pp. 224–228, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Dalle Carbonare, M. T. Valenti, F. Bertoldo et al., “Bone microarchitecture evaluated by histomorphometry,” Micron, vol. 36, no. 7-8, pp. 609–616, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. WHO Study Group, “Assessment of fracture risk and its application to screening for postmenopausal osteoporosis,” Tech. Rep. 843, World Health Organization, 1994. View at Google Scholar
  23. A. Orlandi, F. Oliva, G. Taurisano et al., “Transglutaminase-2 differently regulates cartilage destruction and osteophyte formation in a surgical model of osteoarthritis,” Amino Acids, vol. 36, no. 4, pp. 755–763, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Ferlosio, G. Arcuri, E. Doldo et al., “Age-related increase of stem marker expression influences vascular smooth muscle cell properties,” Atherosclerosis, vol. 224, pp. 51–57, 2012. View at Google Scholar
  25. R. Lindsay, S. L. Silverman, C. Cooper et al., “Risk of new vertebral fracture in the year following a fracture,” Journal of the American Medical Association, vol. 285, no. 3, pp. 320–323, 2001. View at Google Scholar · View at Scopus
  26. H. Enomoto, I. Inoki, K. Komiya et al., “Vascular endothelial growth factor isoforms and their receptors are expressed in human osteoarthritic cartilage,” The American Journal of Pathology, vol. 162, no. 1, pp. 171–181, 2003. View at Google Scholar · View at Scopus
  27. R. E. Fransès, D. F. McWilliams, P. I. Mapp, and D. A. Walsh, “Osteochondral angiogenesis and increased protease inhibitor expression in OA,” Osteoarthritis and Cartilage, vol. 18, no. 4, pp. 563–571, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Xian, X. Wu, L. Pang et al., “Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells,” Nature Medicine, vol. 18, pp. 1095–1101, 2012. View at Google Scholar
  29. V. Cervelli, M. G. Scioli, P. Gentile et al., “Platelet-rich plasma greatly potentiates insulin-induced adipogenic differentiation of human adipose-derived stem cells through a serine/threonine kinase Akt-dependent mechanism and promotes clinical fat graft maintenance,” Stem Cells Translational Medicine, vol. 1, pp. 206–220, 2012. View at Google Scholar
  30. S. Maeda, T. Nobukuni, K. Shimo-Onoda et al., “Sortilin is upregulated during osteoblastic differentiation of mesenchymal stem cells and promotes extracellular matrix mineralization,” Journal of Cellular Physiology, vol. 193, no. 1, pp. 73–79, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. L. Campagnolo, G. Costanza, A. Francesconi, G. Arcuri, I. Moscatelli, and A. Orlandi, “Sortilin expression is essential for pro-nerve growth factor-induced apoptosis of rat vascular smooth muscle cells,” PLoS ONE, vol. 9, Article ID e84969, 2014. View at Google Scholar
  32. V. Tarallo, L. Vesci, O. Capasso et al., “A placental growth factor variant unable to recognize Vascular Endothelial Growth Factor (VEGF) receptor-1 inhibits VEGF-dependent tumor angiogenesis via heterodimerization,” Cancer Research, vol. 70, no. 5, pp. 1804–1813, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. G. Cassinelli, V. Zuco, G. Petrangolini et al., “The curative efficacy of namitecan (ST1968) in preclinical models of pediatric sarcoma is associated with antiangiogenic effects,” Biochemical Pharmacology, vol. 84, pp. 163–171, 2012. View at Publisher · View at Google Scholar · View at Scopus