Research Article
Functional Analysis of Thyroid Peroxidase Gene Mutations Detected in Patients with Thyroid Dyshormonogenesis
Table 3
Clinical manifestations of case at initial presentation.
| Clinical manifestations | Case () | % | Control () | % | value |
|
*Family history | | | | | | Present | 93 | 46.5 | 6 | 3 | <0.0001 | Absent | 107 | 53.5 | 194 | 97 |
*Goiter | | | | | | Present | 131 | 65.5 | — | — | |
*Weight gain | | | | | | Yes | 90 | 45 | 67 | 34 | 0.024 | No | 110 | 55 | 133 | 66 | Loss of memory | | | | | | Yes | 102 | 51 | 90 | 45 | 0.27 | No | 98 | 49 | 110 | 55 |
*Lethargy | | | | | | Yes | 122 | 61 | 91 | 46 | 0.002 | No | 78 | 39 | 109 | 54 |
*Muscle cramp | | | | | | Yes | 110 | 55 | 88 | 44 | 0.03 | No | 90 | 45 | 112 | 56 |
*Cold intolerance | | | | | | Yes | 120 | 60 | 113 | 57 | 0.54 | No | 80 | 40 | 87 | 43 |
*Constipation | | | | | | Yes | 109 | 55 | 80 | 40 | 0.005 | No | 91 | 45 | 120 | 60 |
|
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at the time of diagnosis.
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