Stability of miR-126 in Urine and Its Potential as a Biomarker for Renal Endothelial Injury with Diabetic Nephropathy
Table 1
Clinical characteristics of T2DM patients with and without DN.
Characteristics
Healthy controls ()
DM without DN (86)
DN before treatment (92)
DN after treatment (92)
Well controlled (80)
Not well controlled (12)
Sex (M : F)
36 : 49
47 : 39
57 : 35
50 : 30
7 : 5
0.62
0.75
Age (years ± SD)
52.1 ± 5.6
49.3 ± 4.7
50.3 ± 7.4
51.2 ± 6.3
49.5 ± 8.5
0.72
0.83
BMI Kg/m2
24.07 ± 1.21
23.45 ± 1.02
23.17 ± 0.98
24.58 ± 1.16
23.66 ± 1.32
0.68
0.83
SBP (mmHg)
128.4 ± 10.6
129.7 ± 13.2
130.5 ± 11.7
127.8 ± 12.6
129.8 ± 12.9
0.89
0.93
DBP (mmHg)
78.2 ± 8.7
79.1 ± 6.9
80.4 ± 8.5
78.4 ± 7.4
75.3 ± 9.3
0.92
0.87
Fasting glucose (mmol/L)
3.98 ± 0.77
8.37 ± 3.46
5.32 ± 0.25
4.81 ± 2.32
4.54 ± 3.17
<0.05
0.79
HbA1c (%)
5.31 ± 0.32
8.61 ± 0.75
6.26 ± 0.54
6.07 ± 0.61
6.72 ± 0.45
<0.05
0.82
AlbU (g/L)
8.32 ± 3.5
10.32 ± 2.8
437.2 ± 164.6
21.36 ± 8.3
389.7 ± 45.2
<0.05
<0.05
Cys-c (mg/L)
0.62 ± 0.17
0.71 ± 0.21
1.48 ± 1.15
0.67 ± 0.08
1.45 ± 0.78
<0.05
<0.05
UREA (mmol/L)
4.24 ± 1.32
3.98 ± 1.27
6.78 ± 1.90
4.02 ± 1.13
5.79 ± 1.82
<0.05
<0.05
CREA (mmol/L)
53.44 ± 8.26
59.56 ± 7.48
86.43 ± 21.34
54.67 ± 7.14
84.23 ± 19.43
<0.05
<0.05
miR-126 [lg2(50-Ct)]
3.25 ± 0.45
3.76 ± 0.38
5.76 ± 0.33
3.89 ± 0.52
5.24 ± 0.47
<0.05
<0.05
Indicates numbers of subjects in the group. DM: diabetes mellitus; DN: diabetic nephropathy; SBP: systolic blood pressure; DBP: diastolic blood pressure; Hb Alc-A: glycosylated hemoglobin; AlbU: urine albumin; Cys-c: serum cystatin C; CREA: serum creatinine; : comparison to healthy controls, DM without DN, and DN before treatment. : comparison between DN patients well controlled versus not well controlled by the treatment.
