Current hormone users, regardless of whether they used ERT alone or combined HRT, tended to have a better risk profile than women who had never used HRT.
HRT did not reduce the overall rate of CAD events in PMW with established CAD. Moreover, HRT did increase the rate of thromboembolic events and gallbladder disease.
Overall health risks exceeded benefits from use of HRT in healthy PMW. HRT should not be indicated for CAD primary prevention.
Ferrara et al. [82] (Northern California Kaiser Permanente Diabetes Registry)
2003
Survey follow-up study
15,435
ERT alone or combined HRT
3 years
In diabetic PMW without a recent MI, use of combined HRT was associated with decreased risk of MI. However, HRT was associated with increased risk of MI in women with history of a recent MI.