Progressive Improvement of T-Scores in Men with Osteoporosis and Subnormal Serum Testosterone Levels upon Treatment with Testosterone over Six Years
Table 5
Effects of testosterone on metabolic variables (means ± SD).
Visit month
Difference 60
0 month
12 months
24 months
36 months
48 months
60 months
72 months
months-baseline
45
44
36
32
25
10
4
WC (cm)
101.6 ± 6.4
100.1 ± 5.5
99.2 ± 4.9
98.4 ± 4.2
97.7 ± 4.3
97.7 ± 5.2
95.8 ± 4.4
−6.3 ± 0.51
Weight (kg)
97.1 ± 14.4
94.1 ± 13.3
92.2 ± 11.9
91.0 ± 10.7
86.6 ± 9.8
87.0 ± 10.2
86.8 ± 7.9
−14.1 ± 1.11
BMI
29.9 ± 5.0
29.0 ± 4.7
28.7 ± 4.2
28.3 ± 3.8
27.0 ± 3.4
27.5 ± 4.1
27.7 ± 2.5
−4.4 ± 0.31
Fasting glucose (mg/dL)
5.47 ± 0.36
5.32 ± 0.36
5.35 ± 0.51
5.33 ± 0.32
5.34 ± 0.18
5.39 ± 0.13
5.36 ± 0.06
−0.15 ± 0.112
Total cholesterol (mg/dL)
248 ± 29
195 ± 21
185 ± 17
185 ± 14
183 ± 14
187 ± 12
193 ± 10
−63 ± 51
HDL (mg/dL)
50 ± 15
55 ± 15
58 ± 14
59 ± 15
57 ± 14
57 ± 17
60 ± 19
8 ± 11
LDL (mg/dL)
159 ± 32
143 ± 29
131 ± 25
133 ± 24
132 ± 20
125 ± 28
122 ± 33
−30 ± 31
Triglycerides (mg/dL)
241 ± 32
195 ± 25
186 ± 18
184 ± 13
190 ± 14
188 ± 14
190 ± 10
−55 ± 51
Systolic BP (mm Hg)
136 ± 10
128 ± 9
126 ± 7
127 ± 7
128 ± 5
127 ± 3
126 ± 5
−12 ± 21
Diastolic BP (mm Hg)
83 ± 7
76 ± 5
74 ± 4
75 ± 4
74 ± 4
75 ± 3
71 ± 4
−9 ± 11
AMS
47 ± 10
21 ± 3
18 ± 1
17 ± 1
17 ± 1
17 ± 1
18 ± 1
−30 ± 11
IIEF-EF
19.5 ± 5.1
23.0 ± 4.6
23.8 ± 5.1
23.8 ± 4.7
24.2 ± 4.5
26.6 ± 1.8
28.5 ± 0.6
4.8 ± 0.61
19
7
7
6
3
3
2
HbA1c (%)
5.9 ± 1.3
6.5 ± 1.4
6.2 ± 1.0
5.8 ± 1.0
6.4 ± 0.5
6.1 ± 0.6
6.4 ± 0.8
1.4 ± 0.21
45
19
15
17
12
5
1
CRP (mg/L)
6.2 ± 7.6
3.7 ± 5.4
2.8 ± 3.7
4.2 ± 4.4
2.8 ± 2.9
1.7 ± 1.5
2.2
−7.7 ± 11
. Non significant. WC: Waist Circumference. BMI: Body Mass Index. HDL: High Density Lipoprotein. LDL: Low Density Lipoprotein. BP: Blood Pressure. AMS: Aging Male Symptoms Scale. IIEF-EF: International Index of Erectile Function.
HbA1c: Hemoglobin A1c. CRP: C-reactive protein.
