Multiple Components of the VHL Tumor Suppressor Complex Are Frequently Affected by DNA Copy Number Loss in Pheochromocytoma

<table>Frequency plot displaying two VHL-related tumors, renal clear cell carcinoma and pheochromocytoma, and corresponding types of DNA-level alterations that affect each individual complex component. The figure shows patterns and frequency of DNA copy number loss (red) and mutation (blue) affecting each component of the VHL complex in the two tumor types.</table>

International Journal of Endocrinology

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Figure 4

Figure 4: Multiple Components of the VHL Tumor Suppressor Complex Are Frequently Affected by DNA Copy Number Loss in Pheochromocytoma 