Vitamin D Binding Protein and Bone Health

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td align="left">Phenotype</td><td align="center">rs7041 (D432E)</td><td align="center">rs4588 (T436K)</td><td align="center">DBP levels in homozygotes</td><td align="center">25(OH) D affinity</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td align="left">GC1F</td><td align="center">t (D: asp)</td><td align="center">c (T: thr)</td><td align="center">Lowest</td><td align="center">Highest</td></tr><tr><td align="left">GC1S</td><td align="center">g (E: glu)</td><td align="center">c (T: thr)</td><td align="center">Highest</td><td align="center">Intermediate</td></tr><tr><td align="left">GC2</td><td align="center">t (D: asp)</td><td align="center">a (K: lys)</td><td align="center">Intermediate</td><td align="center">Lowest</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>
              The three most widely studied variants of DBP include GC1F, GC1S, and GC2, which are distinguished by their SNPs rs7041 and rs4588. The associated nucleotide and amino acid changes are presented, along with known data on DBP levels in homozygotes and affinity for 25(OH) D (derived from Powe et al. [<a href="/journals/ije/2014/561214/#B29">9</a>] and Arnaud and Constans [<a href="/journals/ije/2014/561214/#B7">7</a>]). Conflicting data regarding these relationships remain [<a href="/journals/ije/2014/561214/#B12">10</a>].<br/></td></tr></table>

Common phenotypic variants of DBP and associated characteristics.

International Journal of Endocrinology

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Table 1

Table 1: Vitamin D Binding Protein and Bone Health 