Influence of the A3669G Glucocorticoid Receptor Gene Polymorphism on the Metabolic Profile of Pediatric Patients with Congenital Adrenal Hyperplasia

Table 3

Influence of BclI polymorphism on the metabolic profile of CAH patients.

Variables	Genotypes		𝑃 value^a	Adjusted; 𝑃 value
	BclI; 𝑛=20	Wild type; 𝑛=21
Obesity, 𝑛 (%)	6 (33.3)	7 (30.4)	0.888	0.120
Metabolic syndrome, 𝑛 (%)	4 (22.2)	2 (8.7)	0.441	0.359
GC dose, mean (SD), mg/m^2	10.3 (4.0)	9.4 (4.4)	0.561	0.614
Duration of GC therapy, mean (SD), years	10.9 (4.8)	9.4 (4.6)	0.464	0.880
𝑧BMI, mean (SD)	1.01 (1.06)	0.8 (0.91)	0.549	0.541
Waist circumference, mean (SD), cm	69.6 (11.5)	67.9 (6.5)	0.630	0.553
Hip, mean (SD), cm	84.6 (13.4)	84.1 (9.1)	0.903	0.825
Hip-waist ratio, mean (SD)	0.82 (0.07)	0.81 (0.04)	0.484	0.421
Increased waist circumference, (SD), 𝑛 (%)	9 (50)	12 (52.1)	0.860	0.725
Fasting glucose, mean (SD), mg/dL	84.7 (11.1)	82.7 (8.3)	0.890	0.570
Fasting insulin mean (SD), 𝜇lU/mL	11.4 (6.6)	15.3 (10.6)	0.221	0.263
HOMA-IR, mean (SD)	1.43 (0.82)	1.91 (1.27)	0.219	0.248
HOMA-S, mean (SD)	91.7 (49.4)	72.8 (39.8)	0.233	0.230
HOMA-B, mean (SD)	141.8 (61.7)	175.2 (75.4)	0.165	0.222
Total cholesterol, mean (SD), mg/dL	153.7 (42.4)	146.9 (22.8)	1.00	0.827
HDL-c, mean (SD), mg/dL	46.3 (12.0)	45.2 (15.8)	0.601	0.836
LDL-c, mean (SD), mg/dL	93.2 (37.3)	89.2 (16.7)	0.732	0.700
Triglycerides, mean (SD), mg/dL	70.9 (36.1)	63.5 (27.5)	0.652	0.938
Increased blood pressure, 𝑛 (%)	3 (16.7)	1 (4.3)	0.430	0.324

Values are given as means ± SD.
Adjusted for age, sex, and clinical form.
aUnivariated analysis.’