Review Article
Central Hypogonadotropic Hypogonadism: Genetic Complexity of a Complex Disease
Table 2
Nucleotide variants identified so far in the two human genes TAC3 and TACR3.
| Gene | Variants | Synonymous | Non synonymous | Splicing |
| TAC3 | ā | G20fsX39 M90T | c.209-1G>C |
| TACR3 | L58L V98V T246T S448S | G18D S27X G93D Y145X H148L W208X I249V Y256H W275X R295S Y315C | IVS1+1delG c.738-1G>A |
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