Review Article

Central Hypogonadotropic Hypogonadism: Genetic Complexity of a Complex Disease

Table 2

Nucleotide variants identified so far in the two human genes TAC3 and TACR3.

GeneVariants
Synonymous Non synonymous Splicing

TAC3 ā€‰G20fsX39
M90T
c.209-1G>C

TACR3 L58L
V98V
T246T
S448S
G18D
S27X
G93D
Y145X
H148L
W208X
I249V
Y256H
W275X
R295S
Y315C
IVS1+1delG
c.738-1G>A