TY - JOUR A2 - Yu, Yi-Hao AU - Hsiao, Fone-Ching AU - Lin, Yuh-Feng AU - Hsieh, Po-Shiuan AU - Chu, Nain-Feng AU - Chen, Yii-Der Ida AU - Shieh, Yi-Shing AU - Hsieh, Chang-Hsun AU - Lee, Chien-Hsing AU - Lee, Ting-I AU - Hung, Yi-Jen PY - 2014 DA - 2014/02/18 TI - Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents SP - 674069 VL - 2014 AB - The present study was designed to explore the effects of GAS6 and AXL gene polymorphisms on adiposity, systemic inflammation, and insulin resistance in adolescents. After multistage sampling from the data of the Taipei Children Heart Study-III, we collected 358 boys and 369 girls with an average age of 13.3 years. We genotyped the adolescents’ GAS6 rs8191973, GAS6 rs8191974, AXL rs4802113, and AXL rs2304232 polymorphisms. Significantly higher body mass index (BMI), waist circumference (WC), and hsCRP levels were found in boys with the GG genotype of GAS6 rs8191974 than A allele carriers; higher IL-6 and insulin levels and increased HOMA-IR were found in boys with the GG genotype of AXL rs2304232 than the A allele carriers. There was a significant difference in hsCRP levels of boys with the TT, TC, and CC genotypes of AXL rs4802113. Boys with both the GG genotype of GAS6 rs8191973 and the GG genotype of GAS6 rs8191974 exhibited higher BMI, WC, IL-6, and hsCRP levels than the boys carrying both the C allele of the GAS6 rs8191973 and the A allele of the GAS6 rs8191974. In conclusion, GAS6 and AXL polymorphisms are associated with adiposity, systemic inflammation, and insulin resistance in adolescents, especially in boys. SN - 1687-8337 UR - https://doi.org/10.1155/2014/674069 DO - 10.1155/2014/674069 JF - International Journal of Endocrinology PB - Hindawi Publishing Corporation KW - ER -