Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents

Table 2

Anthropometric and biochemical data with different GAS6 rs8191974 genotypes among boys and girls.

	Boys			Girls
	GG	GA	AA	GG	GA	AA
	(n = 213)	(n = 132)	(n = 13)	(n = 242)	(n = 109)	(n = 18)
BMI (kg/m^2)	22.5 ± 4.2^b	22.0 ± 3.6^b	20.7 ± 3.3^b	21.2 ± 3.3	21.3 ± 3.4	20.3 ± 2.3
WC (cm)	80.6 ± 11.0^b	79.3 ± 9.5^b	76.7 ± 9.4^b	75.8 ± 8.1	75.2 ± 8.2	74.6 ± 8.3
hsCRP (mg/L)	0.8 ± 1.2^a,b	1.1 ± 1.6^a,b	0.4 ± 0.2^a,b	0.6 ± 1.0	0.5 ± 0.5	0.9 ± 1.3
TNF-α (pg/mL)	26.7 ± 8.2	25.5 ± 10.1	23.8 ± 4.6	24.5 ± 9.3	22.9 ± 6.5	27.9 ± 4.3
IL-6 (pg/mL)	3.4 ± 2.8	3.3 ± 3.2	2.5 ± 1.3	3.2 ± 2.8	3.1 ± 3.0	2.9 ± 0.7
Glucose (mg/dL)	94.0 ± 6.3	93.4 ± 6.4	95.3 ± 3.6	91.8 ± 6.7	90.6 ± 6.3	92.1 ± 5.7
Insulin (μU/mL)	14.9 ± 8.7	15.3 ± 9.0	15.0 ± 8.2	15.0 ± 8.1	13.9 ± 6.6	11.7 ± 4.2
HOMA-IR	3.5 ± 2.2	3.6 ± 2.2	3.5 ± 2.0	3.4 ± 2.0	3.1 ± 1.5	2.7 ± 1.1
Gas6 (ng/mL)	13.1 ± 3.7	13.2 ± 3.7	13.0 ± 3.1	11.8 ± 3.1	12.1 ± 3.0	1.7 ± 2.2

Data are expressed as mean ± SD.
BMI: body mass index; WC: waist circumference; HOMA-IR: homeostasis model assessment of insulin resistance; hsCRP: high-sensitivity C-reactive protein; TNF-α: tumor necrosis factor-α; IL-6: interleukin-6.
^aGG versus GA versus AA, P < 0.05; ^bGG versus (GA + AA), P < 0.05. All comparisons were analyzed using a general linear model after adjusting for age, Tanner stages, smoking status, drinking status, and physical activity.