Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents

Table 4

Anthropometric and biochemical data with different AXL rs2304232 genotypes among boys and girls.

	Boys			Girls
	AA	AG	GG	AA	AG	GG
	(n = 180)	(n = 143)	(n = 35)	(n = 165)	(n = 161)	(n = 43)
BMI (kg/m^2)	22.3 ± 3.7	22.2 ± 3.9	22.4 ± 5.4	21.4 ± 3.5	21.0 ± 3.3	21.2 ± 2.5
WC (cm)	79.8 ± 10.1	80.3 ± 10.0	79.5 ± 13.8	75.7 ± 8.6	75.5 ± 7.9	75.0 ± 7.3
hsCRP (mg/L)	0.9 ± 1.5	0.8 ± 1.0	0.8 ± 1.5	0.5 ± 0.8	0.5 ± 0.8	0.8 ± 1.4
TNF-α (pg/mL)	26.9 ± 6.0	25.2 ± 7.0	24.7 ± 7.7	24.7 ± 7.5	25.4 ± 8.4	28.1± 9.5
IL-6 (pg/mL)	3.1 ± 3.0^a	3.2 ± 3.1^a	4.8 ± 4.0^a	3.2 ± 3.1	3.0 ± 1.8	3.7 ± 3.5
Glucose (mg/dL)	93.7 ± 5.8	94.0 ± 6.2	93.4 ± 8.4	91.3 ± 6.5	91.5 ± 6.7	92.0 ± 6.0
Insulin (μU/mL)	15.4 ± 9.3^a	14.5 ± 8.2^a	15.9 ± 8.6^a	15.1 ± 7.5	14.0 ± 7.9	14.1 ± 6.1
HOMA-IR	3.6 ± 2.3^a	3.4 ± 2.0^a	3.7 ± 2.3^a	3.4 ± 1.8	3.2 ± 1.9	3.2 ± 1.4

Data are expressed as mean ± SD.
BMI: body mass index; WC: waist circumference; HOMA-IR: homeostasis model assessment of insulin resistance; hsCRP: high-sensitivity C-reactive protein; TNF-α: tumor necrosis factor-α; IL-6: interleukin-6.
^a(AA + AG) versus GG, P < 0.05. All comparisons were analyzed using a general linear model after adjusting for age, Tanner stages, smoking status, drinking status, and physical activity.