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International Journal of Endocrinology
Volume 2014, Article ID 675796, 7 pages
http://dx.doi.org/10.1155/2014/675796
Clinical Study

Relationship between the Prevalence of Thyroid Nodules and Metabolic Syndrome in the Iodine-Adequate Area of Hangzhou, China: A Cross-Sectional and Cohort Study

1Department of International Health Care Center, The Second Affiliated Hospital ZheJiang University College of Medicine, Hangzhou, Zhejiang 310009, China
2Department of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University College of Medicine, Hangzhou, Zhejiang 310009, China
3Department of Ultrasound, The Second Affiliated Hospital Zhejiang University College of Medicine, Hangzhou, Zhejiang 310009, China
4Department of Clinical Laboratory, The Second Affiliated Hospital Zhejiang University College of Medicine, Hangzhou, Zhejiang 310009, China
5Department of Oncology, Cancer Institute, The Second Affiliated Hospital Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China

Received 18 April 2014; Revised 9 July 2014; Accepted 28 July 2014; Published 17 August 2014

Academic Editor: Lorenzo Piemonti

Copyright © 2014 Junhua Yin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The association between thyroid nodule (TN) prevalence and metabolic syndrome (MetS) has only rarely been examined in iodine-adequate areas and needs further clarification. We investigated correlations between MetS and TN prevalence in the iodine-adequate area of Hangzhou, China. Material and Method. A cross-sectional study that screened and recruited individuals for cohort research 3 years later. The 13522 subjects (8926 men, 4596 women) were screened in 2009 for all MetS components, thyroid ultrasound (US), and thyroid function. Cohort research recruited 1610 subjects who were screened in both 2009 and 2012, of whom 1061 underwent follow-up research. Results. The prevalence of TN was higher in the MetS (+) group than in the MetS (−) group (χ2 = 69.63, P < 0.001) and higher in women than in men (χ2 = 11.65, P = 0.001). Waist circumference (WC) was positively related to the prevalence of TN (OR = 1.022, P < 0.001). Individuals with greater WC in 2009 were more likely to suffer from TN in 2012 (RR = 1.434, P = 0.024). Elevated triglyceride level was a risk factor for developing new TN (RR = 1.001, P = 0.035). Conclusion. Both greater WC and elevated triglycerides are risk factors for new TN in this iodine-adequate area in China.