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International Journal of Endocrinology
Volume 2014, Article ID 690704, 5 pages
Clinical Study

Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto’s Thyroiditis

1Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland
2Department of Human Anatomy, Medical University of Bialystok, Mickiewicza 2A, 15-230 Białystok, Poland
3Centre for Clinical Research, Medical University of Bialystok, J. Waszyngtona 15A, 15-276, Poland
4Department of Statistics and Medical Informatics, Medical University of Bialystok, Szpitalna 37, 15-295 Białystok, Poland

Received 17 December 2013; Accepted 18 January 2014; Published 4 March 2014

Academic Editor: Alexander Schreiber

Copyright © 2014 Anna Popławska-Kita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. The aim of the study was to compare the expression of sodium iodide symporter (NIS), thyroglobulin (Tg), tumor necrosis factor-α (TNFα), and interleukin-1β genes in patients with Hashimoto’s thyroiditis (HT) and healthy individuals. Subjects and Methods. Thyroid cells were obtained from 39 patients with HT and 15 controls by an ultrasound guided fine needle aspiration biopsy. Results. The patients with HT had lower Tg and NIS mRNA ( and , resp.), as well as higher TNFα mRNA expression () than the controls. In the HT group Tg mRNA expression correlated positively with NIS mRNA expression (, ) and thyroid volume (, ), as well as negatively with TNFα mRNA expression (, ) and anti-peroxidase antibodies (TPOAb) level (, ), whereas NIS mRNA expression correlated positively with thyroid volume (, ), as well as negatively with TNFα mRNA expression (, ) and TPOAb level (, ). Conclusions. Our results suggest that decreased Tg and NIS expression in thyroid cells may result in reduced active iodide transport and reduced thyroid volume in patients with HT.