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International Journal of Endocrinology
Volume 2014, Article ID 703696, 6 pages
http://dx.doi.org/10.1155/2014/703696
Research Article

Plasma Antimicrobial Peptide LL-37 Level Is Inversely Associated with HDL Cholesterol Level in Patients with Type 2 Diabetes Mellitus

1Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
2Department of Internal Medicine, Saiseikai Central Hospital, 1-4-17 Mita, Minato-ku, Tokyo 108-0073, Japan
3Minami-Aoyama Home Clinic, 7-5-2 Minami Aoyama, Minato-ku, Tokyo 107-0062, Japan
4Department of Pathology, National Institute of Infectious Disease, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-0052, Japan

Received 7 January 2014; Revised 17 February 2014; Accepted 17 February 2014; Published 26 March 2014

Academic Editor: Faustino R. Pérez-López

Copyright © 2014 Shu Meguro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Relation between atherosclerosis and innate immunity has attracted attention. As the antimicrobial peptide, LL-37, could have an important role in atherosclerosis, we supposed that there could be a meaningful association of plasma LL-37 level with risk factors for cardiovascular disease in subjects with type 2 diabetes mellitus. Materials and Methods. We evaluated plasma LL-37 level and other clinical markers in Japanese subjects with type 2 diabetes mellitus (, 115 men and 18 women; age years; HbA1c %). Plasma level of LL-37 was measured by ELISA. Results. Mean plasma LL-37 level was  ng/mL. Plasma LL-37 level showed significant correlations with HDL cholesterol (, ), triglyceride (, ), and high sensitive C-reactive protein (, ) but no significant correlation with age, body mass index, HbA1c, estimated glomerular filtration rate, 25-hydroxyvitamin D, or vitamin D binding protein. Multiple linear regression analysis showed significant correlations of plasma LL-37 level with HDL cholesterol (, ) and high sensitive C-reactive protein (, ). Conclusion. Plasma LL-37 level was positively correlated with inflammatory markers and negatively correlated with HDL cholesterol in patients with type 2 diabetes mellitus.