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International Journal of Endocrinology
Volume 2014 (2014), Article ID 732736, 5 pages
Research Article

Primary Thyroid Disorders in Patients with Endogenous Hypercortisolism: An Observational Study

Department of Endocrinology and Metabolism, Yildirim Beyazit University Medical School Ataturk Teaching and Research Hospital, Bilkent, Sokak No. 10/6, Ceyhun Atıf Kansu Caddesi 1268, Ehlibeyt Mahallesi, 06520 Balgat, Cankaya, Ankara, Turkey

Received 10 March 2014; Revised 27 April 2014; Accepted 28 April 2014; Published 5 May 2014

Academic Editor: Maria L. Dufau

Copyright © 2014 Eda Demir Onal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cushing’s syndrome (CS) may alter the performance of the hypothalamic-hypophyseal-thyroid axis. We searched for a relationship between hypercortisolism and primary thyroid disorders. The medical records of 40 patients with CS were retrospectively examined. Thyroid ultrasonography (USG), basal thyroid function test results (TFT), and antithyroglobulin and antithyroperoxidase antibodies were analyzed. In 80 control subjects, matched by age and gender with CS patients, thyroid USG, TFTs, and autoantibody panel were obtained. Among the CS patients, 17 had nodular goiter, versus 24 controls (42.5% versus 30%, ). Among the twenty-five patients with an available TFT and autoantibody panel—before and after surgical curative treatment—autoantibody positivity was detected in 2 (8%) patients before and 3 (12%) after surgery ( ). Regarding TFT results, 1 (2.5%) patient had subclinical hyperthyroidism and 1 (2.5%) had subclinical hypothyroidism, whereas 1 (2.5%) control had hyperthyroidism. In total, 21 (52.5%) patients and 32 (40%) controls had 1 of the features of thyroid disorder, including goiter, positive thyroid autoantibody, and thyroid function abnormality; the difference was not significant ( ). The prevalence of primary thyroid disorders is not significantly increased in patients with CS.