MicroRNA Deregulation in Anaplastic Thyroid Cancer Biology

Figure 3

Thyroid oncogenesis and miRNAs. Activation of MAPK oncogenes by mutations or rearrangements leads to PTC. Progression to ATC may be associated with the acquisition of additional genetic alterations such as TP53 mutations. Deregulation of miRNA occurs during thyroid oncogenesis, with specific upregulation of miRNAs such as miR-146, miR-221, miR-222, and miR-17-92 cluster, and loss of let-7 expression, in both PTC and ATC. Exclusive downregulation of miRNAs, such as miR-200 and miR-30, is observed in ATC.