Review Article
Update on Anaplastic Thyroid Carcinoma: Morphological, Molecular, and Genetic Features of the Most Aggressive Thyroid Cancer
Table 3
Immunohistochemical features of ATCs.
| | Immunostain | Percentage of positive cases |
| | Cytokeratin | 40–100% | | Vimentin | 100% (in spindle cells) | | EMA | 30–50% (in squamoid cells) | | CEA | Rarely (in squamoid cells) | | Thyroglobulin | 0% (false positivity due to nonneoplastic thyroid follicular cells entrapped in the tumor or diffusion from destroyed normal follicles) | | TTF-1 | 0% | | RET/PTC oncoprotein | 0% | | Calcitonin | 0% | | PAX8 | 0–79% of ATCs (probably depending on antibody used);
92% of ATCs with squamoid features |
|
|
