Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice
Figure 6
Baicalein promoted viability of -cells and human islets. INS382/13 cells (a) or human islets (100 islets/well) (b) were cultured in RPMI medium containing 5.5 mM glucose and 2% FBS in the presence or absence of various concentrations of baicalein for 24 h. Cell viability was measured using a Cell Titer-Blue Cell viability assay kit. INS382/13 cells (c) or human islets (150 islets/well) (d) were cultured in RPMI medium containing 0.5 mM palmitate (P) or vehicle with or without various concentrations of baicalein (B) for 3 d. Cell viability was assessed as above. Data are expressed as mean ± SE from 3-4 independent experiments with quadruplicate determinations each. versus control, versus palmitate-alone treated cells or islets.
