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International Journal of Endocrinology
Volume 2014, Article ID 857270, 9 pages
http://dx.doi.org/10.1155/2014/857270
Research Article

Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index

1Laboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS) and Santiago de Compostela University (USC), 15706 Santiago de Compostela, Spain
2CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, Spain
3Obesidómica Group, Laboratory 3, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain
4Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain
5Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, 08907 Barcelona, Spain
6Department of Clinical Sciences, School of Medicine, University of Barcelona, 08007 Barcelona, Spain
7Department of Psychological, Personality, Evaluation and Treatment of the University of Valencia, 46010 Valencia, Spain
8Department of Basic Psychology, Clinic and Psychobiology of the Jaume I University, Castelló, 12071 Castelló de la Plana, Spain
9Human Pharmacology and Clinical Neurosciences Research Group, Neuroscience Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain
10Center for Genomic Regulation (CRG), 08003 Barcelona, Spain
11Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain
12Department of Diabetes, Endocrinology and Nutrition, Institut d’Investigació Biomèdica de Girona (IdlBGi), Hospital Dr Josep Trueta, Girona, Spain
13Department of Diabetes, Endocrinology and Nutrition, Hospital Cliínico Universitario Virgen de Victoria, 29010 Maálaga, Spain
14Department of Endocrinology and Nutrition, University Clinic de Navarra, University of Navarra, 31008 Pamplona, Spain

Received 12 December 2013; Revised 28 February 2014; Accepted 28 February 2014; Published 22 April 2014

Academic Editor: Maria L. Dufau

Copyright © 2014 María Pardo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [94 citations]

The following is the list of published articles that have cited the current article.

  • Chia Lin Chang, Shang Yu Huang, Yung Kuei Soong, Po Jen Cheng, Chin-Jung Wang, and I. Ting Liang, “Circulating Irisin and Glucose-Dependent Insulinotropic Peptide Are Associated With the Development of Polycystic Ovary Syndrome,” Journal Of Clinical Endocrinology & Metabolism, vol. 99, no. 12, pp. E2539–E2548, 2014. View at Publisher · View at Google Scholar
  • A.B. Crujeiras, M. Pardo, and F.F. Casanueva, “Irisin: ‘fat’ or artefact,” Clinical Endocrinology, 2014. View at Publisher · View at Google Scholar
  • Haibo Song, Lijun Yang, Xing Li Wang, Taixing Cui, Dongqi Tang, Fei Wu, Yuan Zhang, Yuzhu Zhang, Fang Wang, Miao Jiang, Zhongde Wang, Mingxiang Zhang, and Shiwu Li, “Irisin promotes human umbilical vein endothelial cell proliferation through the ERK signaling pathway and partly suppresses high glucose-induced apoptosis,” PLoS ONE, vol. 9, no. 10, 2014. View at Publisher · View at Google Scholar
  • Harry J. Hirsch, Itai Gross, Yehuda Pollak, Talia Eldar-Geva, and Varda Gross-Tsur, “Irisin and the metabolic phenotype of adults with Prader-Willi syndrome,” PLoS ONE, vol. 10, no. 9, 2015. View at Publisher · View at Google Scholar
  • Shanhu Qiu, Xue Cai, Zilin Sun, Uwe Schumann, Martina Zügel, and Jürgen Michael Steinacker, “Chronic Exercise Training and Circulating Irisin in Adults: A Meta-Analysis,” Sports Medicine, vol. 45, no. 11, pp. 1577–1588, 2015. View at Publisher · View at Google Scholar
  • Jonato Prestes, Dahan da Cunha Nascimento, Ramires Alsamir Tibana, Tatiane Gomes Teixeira, Denis Cesar Leite Vieira, Vitor Tajra, Darlan Lopes de Farias, Alessandro Oliveira Silva, Silvana Schwerz Funghetto, Vinicius Carolino de Souza, and James Wilfred Navalta, “Understanding the individual responsiveness to resistance training periodization,” Age, vol. 37, no. 3, 2015. View at Publisher · View at Google Scholar
  • Min-Jung Park, Dong-Il Kim, Joo-Hee Choi, Young-Ran Heo, and Soo-Hyun Park, “New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro,” Cellular Signalling, 2015. View at Publisher · View at Google Scholar
  • Joo Young Huh, and Christos S. Mantzoros, “Irisin physiology, oxidative stress, and thyroid dysfunction: What next?,” Metabolism, 2015. View at Publisher · View at Google Scholar
  • Dennis Loeffler, Ulrike Mueller, Kathrin Scheuermann, Daniela Friebe, Julia Gesing, Julia Bielitz, Sandra Erbs, Kathrin Landgraf, Isabel Viola Wagner, Wieland Kiess, and Antje Koerner, “Serum Irisin Levels Are Regulated by Acute Strenuous Exercise,” Journal Of Clinical Endocrinology & Metabolism, vol. 100, no. 4, pp. 1289–1299, 2015. View at Publisher · View at Google Scholar
  • Havard Nygaard, Gunnar Slettalokken, Geir Vegge, Ivana Hollan, Jon Elling Whist, Tor Strand, Bent R. Ronnestad, and Stian Ellefsen, “Irisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Training,” Plos One, vol. 10, no. 3, 2015. View at Publisher · View at Google Scholar
  • Berenice Palacios-González, Felipe Vadillo-Ortega, Ernestina Polo-Oteyza, Teresa Sánchez, Monica Ancira-Moreno, Sandra Romero-Hidalgo, Noemi Meráz, and Barbara Antuna-Puente, “Irisin levels before and after physical activity among school-age children with different BMI: A direct relation with leptin,” Obesity, vol. 23, no. 4, pp. 729–732, 2015. View at Publisher · View at Google Scholar
  • A. E. Huerta, P. L. Prieto-Hontoria, M. Fernández-Galilea, N. Sáinz, M. Cuervo, J. A. Martínez, and M. J. Moreno-Aliaga, “Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid,” Journal of Physiology and Biochemistry, 2015. View at Publisher · View at Google Scholar
  • Claire Huth, Marie-Julie Dubois, André Marette, Angelo Tremblay, S. John Weisnagel, Michel Lacaille, Pascale Mauriège, and Denis R. Joanisse, “Irisin is more strongly predicted by muscle oxidative potential than adiposity in non-diabetic men,” Journal of Physiology and Biochemistry, 2015. View at Publisher · View at Google Scholar
  • Xeni Provatopoulou, Georgia P. Georgiou, Eleni Kalogera, Vasileios Kalles, Maira A. Matiatou, Ioannis Papapanagiotou, Alexandros Sagkriotis, George C. Zografos, and Antonia Gounaris, “Serum irisin levels are lower in patients with breast cancer: association with disease diagnosis and tumor characteristics,” BMC Cancer, vol. 15, no. 1, 2015. View at Publisher · View at Google Scholar
  • Fatma H. Rizk, Samah A. Elshweikh, and Amira Y. Abd El-Naby, “Irisin levels in relation to metabolic and liver functions in Egyptian patients with metabolic syndrome,” Canadian Journal of Physiology and Pharmacology, pp. 1–4, 2015. View at Publisher · View at Google Scholar
  • Beatriz García-Fontana, Rebeca Reyes-García, Sonia Morales-Santana, Verónica Ávila-Rubio, Araceli Muñoz-Garach, Pedro Rozas-Moreno, and Manuel Muñoz-Torres, “Relationship between myostatin and irisin in type 2 diabetes mellitus: a compensatory mechanism to an unfavourable metabolic state?,” Endocrine, 2015. View at Publisher · View at Google Scholar
  • Jia-qi Chen, Yue-ye Huang, Aaron M. Gusdon, and Shen Qu, “Irisin: a new molecular marker and target in metabolic disorder,” Lipids in Health and Disease, vol. 14, 2015. View at Publisher · View at Google Scholar
  • Andrea Palermo, Rocky Strollo, Ernesto Maddaloni, Dario Tuccinardi, Luca D'Onofrio, Silvia Irina Briganti, Giuseppe Defeudis, Mariangela De Pascalis, Maria Concetta Lazzaro, Georgia Colleluori, Silvia Manfrini, Paolo Pozzilli, and Nicola Napoli, “Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity,” Clinical Endocrinology, 2015. View at Publisher · View at Google Scholar
  • Luis Gamas, Paulo Matafome, and Raquel Seiça, “Irisin and Myonectin Regulation in the Insulin Resistant Muscle: Implications to Adipose Tissue: Muscle Crosstalk,” Journal of Diabetes Research, vol. 2015, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  • Belviranli, Okudan, and Çelik, “Association of Circulating Irisin with Insulin Resistance and Oxidative Stress in Obese Women,” Hormone and Metabolic Research, vol. 48, no. 10, pp. 653–657, 2016. View at Publisher · View at Google Scholar
  • Anny Mulya, and John P. Kirwan, “Brown and Beige Adipose Tissue,” Endocrinology and Metabolism Clinics of North America, vol. 45, no. 3, pp. 605–621, 2016. View at Publisher · View at Google Scholar
  • Fagundo, Botella, Fernández-García, Frühbeck, Rodríguez, Mallorquí-Bagué, Fernández-Aranda, Crujeiras, Granero, Baños, De La Torre, Fernández-Real, Tárrega, Tinahones, Rodriguez, Jiménez-Murcia, Ortega, Menchón, Casanueva, Giner-Bartolomé, Agüera, Sauchelli, and Pardo, “Modulation of irisin and physical activity on executive functions in obesity and morbid obesity,” Scientific Reports, vol. 6, 2016. View at Publisher · View at Google Scholar
  • Antonino Tuttolomondo, Caterina Schimmenti, Antonio Pinto, Domenico Di Raimondo, Gaia Musiari, and Alessandra D’Angelo, “Are the myokines the mediators of physical activity-induced health benefits?,” Current Pharmaceutical Design, vol. 22, no. 24, pp. 3622–3647, 2016. View at Publisher · View at Google Scholar
  • Yaeko Fukushima, Satoshi Kurose, Hiromi Shinno, Ha Cao Thi Thu, Atsuko Tamanoi, Hiromi Tsutsumi, Takaaki Hasegawa, Toshiaki Nakajima, and Yutaka Kimura, “Relationships between serum irisin levels and metabolic parameters in Japanese patients with obesity,” Obesity Science & Practice, vol. 2, no. 2, pp. 203–209, 2016. View at Publisher · View at Google Scholar
  • Osman Inan, Enes Sahiner, Canan Demir, Aynur Aktas, Mukadder Ayse Bilgic, Ali Akcay, Hakki Yilmaz, Muzaffer Cakmak, and Tahir Darcin, “Circulating irisin levels reflect visceral adiposity in non-diabetic patients undergoing hemodialysis,” Renal Failure, pp. 1–6, 2016. View at Publisher · View at Google Scholar
  • Tomasz Miazgowski, Aleksandra Taszarek, and Anna Kaczmarkiewicz, “Hypertension and beyond - does circulating irisin matter?,” Nadcisnienie Tetnicze, vol. 20, no. 1, pp. 16–20, 2016. View at Publisher · View at Google Scholar
  • S. Barja-Fernández, C. Folgueira, C. Castelao, O. Al-Massadi, S. B. Bravo, T. Garcia-Caballero, R. Leis, M. Pardo, F. F. Casanueva, and L. M. Seoane, “FNDC5 is produced in the stomach and associated to body composition,” Scientific Reports, vol. 6, pp. 23067, 2016. View at Publisher · View at Google Scholar
  • J. Q. Chen, L. J. Fang, K. X. Song, X. C. Wang, Y. Y. Huang, S. Y. Chai, L. Bu, and S. Qu, “Serum Irisin Level is Higher and Related with Insulin in Acanthosis Nigricans-related Obesity,” Experimental And Clinical Endocrinology & Diabetes, vol. 124, no. 3, pp. 203–207, 2016. View at Publisher · View at Google Scholar
  • Nasser M. Al-Daghri, Abdul Khader Mohammed, Omar S. Al-Attas, Osama E. Amer, Mario Clerici, Amal Alenad, and Majed S. Alokail, “SNPs in FNDC5 (irisin) are associated with obesity and modulation of glucose and lipid metabolism in Saudi subjects,” Lipids in Health and Disease, vol. 15, no. 1, 2016. View at Publisher · View at Google Scholar
  • Suman Srinivasa, Caroline Suresh, Jay Mottla, Sulaiman R. Hamarneh, Javier E. Irazoqui, Walter Frontera, Martin Torriani, Takara Stanley, and Hideo Makimura, “FNDC5 relates to skeletal muscle IGF-I and mitochondrial function and gene expression in obese men with reduced growth hormone,” Growth Hormone & IGF Research, vol. 26, pp. 36–41, 2016. View at Publisher · View at Google Scholar
  • Shanhu Qiu, Xue Cai, Han Yin, Martina Zügel, Zilin Sun, Jürgen Michael Steinacker, and Uwe Schumann, “Association between circulating irisin and insulin resistance in non-diabetic adults: a meta-analysis,” Metabolism, 2016. View at Publisher · View at Google Scholar
  • Kyoung-Jin Oh, Da Lee, Won Kim, Baek Han, Sang Lee, and Kwang-Hee Bae, “Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines,” International Journal of Molecular Sciences, vol. 18, no. 1, pp. 8, 2016. View at Publisher · View at Google Scholar
  • Onur Erol, Bekir Sıtkı İsenlik, Özgür Aydın, Aysel Uysal Derbent, Neslihan Erkal, Hamit Yaşar Ellidağ, and Necat Yılmaz, “Irisin as an early marker for predicting gestational diabetes mellitus: a prospective study,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 29, no. 22, pp. 3590–3595, 2016. View at Publisher · View at Google Scholar
  • Alexander Kalinkovich, and Gregory Livshits, “Sarcopenic obesity or obese sarcopenia: a cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis,” Ageing Research Reviews, 2016. View at Publisher · View at Google Scholar
  • Anna Gavrieli, and Christos S. Mantzoros, “Novel Molecules Regulating Energy Homeostasis: Physiology and Regulation by Macronutrient Intake and Weight Loss,” Endocrinology and Metabolism, vol. 31, no. 3, pp. 361, 2016. View at Publisher · View at Google Scholar
  • Yaeko Fukushima, Satoshi Kurose, Hiromi Shinno, Ha Cao Thi Thu, Nana Takao, Hiromi Tsutsumi, Takaaki Hasegawa, Toshiaki Nakajima, and Yutaka Kimura, “Effects of Body Weight Reduction on Serum Irisin and Metabolic Parameters in Obese Subjects,” Diabetes & Metabolism Journal, vol. 40, no. 5, pp. 386, 2016. View at Publisher · View at Google Scholar
  • Mustafa Demirpence, Hamiyet Yilmaz, Ayfer Colak, Burak Toprak, Levent Ugurlu, Hulya Yalcin, Hakan Turkon, and Cengiz Aydin, “The effect of sleeve gastrectomy on serum irisin levels in patients with morbid obesity,” Endokrynologia Polska, vol. 67, no. 5, pp. 481–486, 2016. View at Publisher · View at Google Scholar
  • Silvio Buscemi, Davide Corleo, Carola Buscemi, and Carla Giordano, “Does iris(in) bring bad news or good news?,” Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, 2017. View at Publisher · View at Google Scholar
  • Ashraf A. Foda, Engy A. Foda, and Ibrahim Abel-Aal, “Serum Irisin levels as a marker in some phenotypes of PCOS,” Middle East Fertility Society Journal, 2017. View at Publisher · View at Google Scholar
  • Chunbo Cai, Gaojun Xiao, Lili Qian, Shengwang Jiang, Biao Li, Shanshan Xie, Ting Gao, Xiaorong An, Wentao Cui, and Kui Li, “Gene Location, Expression, and Function of FNDC5 in Meishan Pigs,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Ercan Bastu, Umit Zeybek, Ebru Gurel Gurevin, Bahar Yüksel Ozgor, Faruk Celik, Nazli Okumus, Irem Demiral, Ozlem Dural, Cem Celik, Huri Bulut, Elif Ilkay Armutak, Bulent Baysal, Faruk Buyru, and John Yeh, “Effects of Irisin and Exercise on Metabolic Parameters and Reproductive Hormone Levels in High-Fat Diet-Induced Obese Female Mice,” Reproductive Sciences, pp. 193371911771126, 2017. View at Publisher · View at Google Scholar
  • Petros C. Dinas, Ian M. Lahart, James A. Timmons, Per-Arne Svensson, Yiannis Koutedakis, Andreas D. Flouris, and George S. Metsios, “Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review,” F1000Research, vol. 6, pp. 286, 2017. View at Publisher · View at Google Scholar
  • Leonid Poretsky, Julie Islam, Dimiter Avtanski, Yu Kuei Lin, Yi-Ling Shen, Yael Hirth, Martin Lesser, Zev Rosenwaks, and Donna Seto-Young, “Reproductive effects of irisin: Initial in vitro studies,” Reproductive Biology, 2017. View at Publisher · View at Google Scholar
  • Han Byul Jang, Hyo-Jin Kim, Jae Heon Kang, Sang Ick Park, Kyung Hee Park, and Hye-Ja Lee, “Association of circulating irisin levels with metabolic and metabolite profiles of Korean adolescents,” Metabolism, 2017. View at Publisher · View at Google Scholar
  • Jae Seung Chang, Tae Ho Kim, Tuyet Thi Nguyen, Kyu-Sang Park, Nahyun Kim, and In Deok Kong, “Circulating irisin levels as a predictive biomarker for sarcopenia: A cross-sectional community-based study,” Geriatrics & Gerontology International, 2017. View at Publisher · View at Google Scholar
  • Petros C. Dinas, Ian M. Lahart, James A. Timmons, Per-Arne Svensson, Yiannis Koutedakis, Andreas D. Flouris, and George S. Metsios, “Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review,” F1000Research, vol. 6, pp. 286, 2017. View at Publisher · View at Google Scholar
  • Shan Zhou, and Hong-Ying Ye, “A research progress on metabolism-associated myokines,” Fudan University Journal of Medical Sciences, vol. 44, no. 2, pp. 238–241, 2017. View at Publisher · View at Google Scholar
  • Ivan Luiz Padilha Bonfante, Mara Patricia Traina Chacon-Mikahil, Diego Trevisan Brunelli, Arthur Fernandes Gáspari, Renata Garbellini Duft, Alexandre Gabarra Oliveira, Tiago Gomes Araujo, Mario Jose Abdalla Saad, and Cláudia Regina Cavaglieri, “Obese with higher FNDC5/Irisin levels have a better metabolic profile, lower lipopolysaccharide levels and type 2 diabetes risk,” Archives of Endocrinology and Metabolism, vol. 61, no. 6, pp. 524–533, 2017. View at Publisher · View at Google Scholar
  • Xue Cai, Shanhu Qiu, Ling Li, Martina Zügel, Jürgen Michael Steinacker, and Uwe Schumann, “Circulating irisin in patients with polycystic ovary syndrome: a meta-analysis,” Reproductive BioMedicine Online, 2017. View at Publisher · View at Google Scholar
  • D. Pérez-Sotelo, A. Roca-Rivada, I. Baamonde, J. Baltar, A. I. Castro, E. Domínguez, M. Collado, F. F. Casanueva, and M. Pardo, “Lack of Adipocyte-Fndc5/Irisin Expression and Secretion Reduces Thermogenesis and Enhances Adipogenesis,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Stergios A. Polyzos, Athanasios D. Anastasilakis, Zoe A. Efstathiadou, Polyzois Makras, Nikolaos Perakakis, Jannis Kountouras, and Christos S. Mantzoros, “Irisin in metabolic diseases,” Endocrine, 2017. View at Publisher · View at Google Scholar
  • Elena Dozio, Elena Passeri, Rosanna Cardani, Stefano Benedini, Carmen Aresta, Rea Valaperta, Massimiliano Corsi Romanelli, Giovanni Meola, Valeria Sansone, and Sabrina Corbetta, “Circulating Irisin Is Reduced in Male Patients with Type 1 and Type 2 Myotonic Dystrophies,” Frontiers in Endocrinology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • S Buscemi, D Corleo, S Vasto, C Buscemi, M F Massenti, D Nuzzo, G Lucisano, A M Barile, G Rosafio, V Maniaci, and C Giordano, “Factors associated with circulating concentrations of irisin in the general population cohort of the ABCD study,” International Journal of Obesity, 2017. View at Publisher · View at Google Scholar
  • Teresa Jiménez, Gladys Barrera, Rodrigo Troncoso, María Belén Farias, Beatriz Tenorio, Sandra Hirsch, María Pia de la Maza, Juan Manuel Rodríguez, and Daniel Bunout, “Irisin is weakly associated with usual physical activity in young overweight women,” Nutricion Hospitalaria, vol. 34, no. 3, pp. 688–692, 2017. View at Publisher · View at Google Scholar
  • Joice Cristina dos Santos Trombeta, Jonato Prestes, Dahan da Cunha Nascimento, Ramires Alsamir Tibana, Guilherme Borges Pereira, Thiago da Rosa Lima, G?ssica Alves Fraga, Roberto Carlos Vieira-Junior, and Fabr?cio Azevedo Voltarelli, “New insights into the effects of irisin levels in HIV-infected subjects: correlation with adiposity, fat-free mass, and strength parameters,” Archives of Endocrinology and Metabolism, no. 0, 2017. View at Publisher · View at Google Scholar
  • Brianne L. Guilford, Caleb W. Grote, Jake C. Parson, Stephanie N. Vick, Janelle M. Ryals, and Douglas E. Wright, “Increased FNDC5 is associated with insulin resistance in high fat-fed mice,” Physiological Reports, vol. 15, no. 13, 2017. View at Publisher · View at Google Scholar
  • Leticia Elizondo-Montemayor, Christian Silva-Platas, Alejandro Torres-Quintanilla, Carlos Rodríguez-López, Guillermo U. Ruiz-Esparza, Eric Reyes-Mendoza, and Gerardo Garcia-Rivas, “Association of Irisin Plasma Levels with Anthropometric Parameters in Children with Underweight, Normal Weight, Overweight, and Obesity,” BioMed Research International, vol. 2017, pp. 1–11, 2017. View at Publisher · View at Google Scholar
  • Luana G. Leal, Magno A. Lopes, and Miguel L. Batista, “Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases,” Frontiers in Physiology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Ayhan Korkmaz, Mika Venojärvi, Niko Wasenius, Sirpa Manderoos, Keith C. Deruisseau, Eva-Karin Gidlund, Olli J. Heinonen, Harri Lindholm, Sirkka Aunola, Johan G. Eriksson, and Mustafa Atalay, “Plasma irisin is increased following 12 weeks of Nordic walking and associates with glucose homoeostasis in overweight/obese men with impaired glucose regulation,” European Journal of Sport Science, pp. 1–9, 2018. View at Publisher · View at Google Scholar
  • Vesile Ornek Diker, Ali Kemal Kalkan, Huseyin Altug Cakmak, Mehmet Erturk, Kübra Erol Kalkan, Fatih Uzun, Omer Tasbulak, Suleyman Aydin, and Ahmet Celik, “Adropin and irisin in patients with cardiac cachexia,” Arquivos Brasileiros de Cardiologia, vol. 111, no. 1, pp. 39–47, 2018. View at Publisher · View at Google Scholar
  • Tereza Pavlova, Filip Zlamal, Josef Tomandl, Zuzana Hodicka, Sumeet Gulati, and Julie Bienertova-Vasku, “Irisin Maternal Plasma and Cord Blood Levels in Mothers with Spontaneous Preterm and Term Delivery,” Disease Markers, vol. 2018, pp. 1–9, 2018. View at Publisher · View at Google Scholar
  • F. De Meneck, L. Victorino de Souza, V. Oliveira, and M.C. do Franco, “High irisin levels in overweight/obese children and its positive correlation with metabolic profile, blood pressure, and endothelial progenitor cells,” Nutrition, Metabolism and Cardiovascular Diseases, 2018. View at Publisher · View at Google Scholar
  • Ioannis G. Fatouros, “Is irisin the new player in exercise-induced adaptations or not? A 2017 update,” Clinical Chemistry and Laboratory Medicine, vol. 56, no. 4, pp. 525–548, 2018. View at Publisher · View at Google Scholar
  • Abdulkerim Kasim Baltaci, Esma Menevse, Emine Atici, and Rasim Mogulkoc, “Both hypothyroidism and hyperthyroidism increase plasma irisin levels in rats,” Hormone Molecular Biology and Clinical Investigation, vol. 33, no. 3, 2018. View at Publisher · View at Google Scholar
  • Flora Bacopoulou, Nikos Athanasopoulos, Vasiliki Efthymiou, Aimilia Mantzou, Leon Aravantinos, Spiros Vlahopoulos, and Efthymios Deligeoroglou, “Serum irisin concentrations in lean adolescents with polycystic ovary syndrome,” Clinical Endocrinology, 2018. View at Publisher · View at Google Scholar
  • Patricia Ahechu, Gabriel Zozaya, Pablo Martí, José Luis Hernández-Lizoáin, Jorge Baixauli, Xabier Unamuno, Gema Frühbeck, and Victoria Catalán, “NLRP3 Inflammasome: A Possible Link Between Obesity-Associated Low-Grade Chronic Inflammation and Colorectal Cancer Development,” Frontiers in Immunology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Leticia Elizondo-Montemayor, Gerardo Mendoza-Lara, Gustavo Gutierrez-DelBosque, Mariana Peschard-Franco, Bianca Nieblas, and Gerardo Garcia-Rivas, “Relationship of Circulating Irisin with Body Composition, Physical Activity, and Cardiovascular and Metabolic Disorders in the Pediatric Population,” International Journal of Molecular Sciences, vol. 19, no. 12, pp. 3727, 2018. View at Publisher · View at Google Scholar
  • Alessandro Ciresi, Giuseppe Pizzolanti, Valentina Guarnotta, and Carla Giordano, “Circulating Irisin Levels in Children With GH Deficiency Before and After 1 Year of GH Treatment,” The Journal of Clinical Endocrinology & Metabolism, vol. 104, no. 3, pp. 801–808, 2018. View at Publisher · View at Google Scholar
  • Ilse Yessabel Martinez Munoz, Eneida del Socorro Camarillo Romero, and Jose de Jesus Garduno Garcia, “Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions,” International Journal of Endocrinology, vol. 2018, pp. 1–8, 2018. View at Publisher · View at Google Scholar
  • Christian Lunetta, Andrea Lizio, Lucio Tremolizzo, Massimiliano Ruscica, Chiara Macchi, Nilo Riva, Patrick Weydt, Ettore Corradi, Paolo Magni, and Valeria Sansone, “Serum irisin is upregulated in patients affected by amyotrophic lateral sclerosis and correlates with functional and metabolic status,” Journal of Neurology, 2018. View at Publisher · View at Google Scholar
  • Fatemeh Kazeminasab, Sayed Mohammad Marandi, Kamran Ghaedi, Zahra Safaeinejad, Fahimeh Esfarjani, and Mohammad Hossein Nasr-Esfahani, “A comparative study on the effects of high-fat diet and endurance training on the PGC-1α-FNDC5/irisin pathway in obese and nonobese male C57BL/6 mice,” Applied Physiology, Nutrition, and Metabolism, pp. 1–12, 2018. View at Publisher · View at Google Scholar
  • Nilsel Okudan, Muaz Belviranli, and Nuran Karakuyu, “The association between irisin levels, element distribution and oxidative stress markers in adolescent swimmers,” Hormone Molecular Biology and Clinical Investigation, vol. 34, no. 3, 2018. View at Publisher · View at Google Scholar
  • Azza M. Abdu Allah, Sahar Af. Hammoudah, Eman Masoud Abd El Gayed, Lama Mohamed El-Attar, and Walid A. Shehab-Eldin, “Obesity and its association with irisin level among individuals with FNDC5/Irisin gene variants RS16835198 and RS726344,” Protein and Peptide Letters, vol. 25, no. 6, pp. 560–569, 2018. View at Publisher · View at Google Scholar
  • Nikolaos Tentolouris, Dimitrios Tsilingiris, Nikolaos Katsilambros, Anastasios Tentolouris, Ioanna Eleftheriadou, Ioanna A. Anastasiou, Ourania A. Kosta, Iordanis Mourouzis, Alexandros Kokkinos, and Constantinos Pantos, “Plasma Irisin Levels in Subjects with Type 1 Diabetes: Comparison with Healthy Controls,” Hormone and Metabolic Research, vol. 50, no. 11, pp. 803–810, 2018. View at Publisher · View at Google Scholar
  • Б.И. Кузник, С. О. Давыдов, and А.В. Степанов, “РОЛЬ МЫШЕЧНОГО ГОРМОНА ИРИСИНА В РЕГУЛЯЦИИ ФИЗИОЛОГИЧЕСКИХ ФУНКЦИЙ В НОРМЕ И ПАТОЛОГИИ, "Успехи физиологических наук",” Успехи физиологических наук, no. 4, pp. 59–80, 2018. View at Publisher · View at Google Scholar
  • Ilse Yessabel Martínez Muñoz, Eneida del Socorro Camarillo Romero, Trinidad Correa Padilla, Jonnathan Guadalupe Santillán Benítez, María del Socorro Camarillo Romero, Laura Patricia Montenegro Morales, Gabriel Gerardo Huitrón Bravo, and José de Jesús Garduño García, “Association of Irisin Serum Concentration and Muscle Strength in Normal-Weight and Overweight Young Women,” Frontiers in Endocrinology, vol. 10, 2019. View at Publisher · View at Google Scholar
  • Paulina Korta, Ewa Pocheć, and Agnieszka Mazur-Biały, “Irisin as a Multifunctional Protein: Implications for Health and Certain Diseases,” Medicina, vol. 55, no. 8, pp. 485, 2019. View at Publisher · View at Google Scholar
  • Adrian M. Gonzalez-Gil, Mariana Peschard-Franco, Elena C. Castillo, Gustavo Gutierrez-DelBosque, Victor Treviño, Christian Silva-Platas, Luisa Perez-Villarreal, Gerardo Garcia-Rivas, and Leticia Elizondo-Montemayor, “Myokine–adipokine cross-talk: potential mechanisms for the association between plasma irisin and adipokines and cardiometabolic risk factors in Mexican children with obesity and the metabolic syndrome,” Diabetology & Metabolic Syndrome, vol. 11, no. 1, 2019. View at Publisher · View at Google Scholar
  • Magdalena Weber-Rajek, Agnieszka Radzimińska, Agnieszka Strączyńska, Katarzyna Strojek, Zuzanna Piekorz, Mariusz Kozakiewicz, and Hanna Styczyńska, “A Randomized-Controlled Trial Pilot Study Examining the Effect of Pelvic Floor Muscle Training on the Irisin Concentration in Overweight or Obese Elderly Women with Stress Urinary Incontinence,” BioMed Research International, vol. 2019, pp. 1–8, 2019. View at Publisher · View at Google Scholar
  • Aykut Dundar, Sayad Kocahan, and Leyla Sahin, “Associations of apelin, leptin, irisin, ghrelin, insulin, glucose levels, and lipid parameters with physical activity during eight weeks of regular exercise training,” Archives of Physiology and Biochemistry, pp. 1–5, 2019. View at Publisher · View at Google Scholar
  • Yanhua Dong, Siyuan Zhang, Jin Tao, Xiaomeng Zhang, Ju Zhang, Jie Yang, Hao Liang, Dongjun Liu, and Ming Cang, “Fibronectin type III domain-containing protein 5 promotes proliferation and differentiation of goat adipose-derived stem cells,” Research in Veterinary Science, 2019. View at Publisher · View at Google Scholar
  • Chunting Lu, Zejian Li, Jing Yang, Lie Feng, Cunchuan Wang, and Qiping Shi, “Variations in Irisin, Bone Mineral Density, Bone Mineral Content and Body Composition after Laparoscopic Bariatric Procedures in Obese Adults,” Journal of Clinical Densitometry, 2019. View at Publisher · View at Google Scholar
  • Ali Seven, Esin Yalinbas, Suna Kabil Kucur, Emel Kocak, Ozben Isiklar, Beril Yuksel, Hakan Timur, Mehmet Erbakirci, and Nadi Keskin, “Comprehensive evaluation of irisin levels in fetomaternal circulation of pregnant women with obesity or gestational diabetes mellitus,” Irish Journal of Medical Science (1971 -), 2019. View at Publisher · View at Google Scholar
  • Ashraf A. Foda, Engy A. Foda, and Zeinab H. El-Said, “Serum irisin levels in polycystic ovary syndrome after ovarian drilling,” Diabetes and Metabolic Syndrome: Clinical Research and Reviews, vol. 13, no. 2, pp. 1463–1468, 2019. View at Publisher · View at Google Scholar
  • Leticia Elizondo-Montemayor, Adrian M. Gonzalez-Gil, Oscar Tamez-Rivera, Carla Toledo-Salinas, Mariana Peschard-Franco, Nora A. Rodríguez-Gutiérrez, Christian Silva-Platas, and Gerardo Garcia-Rivas, “Association between Irisin, hs-CRP, and Metabolic Status in Children and Adolescents with Type 2 Diabetes Mellitus,” Mediators of Inflammation, vol. 2019, pp. 1–13, 2019. View at Publisher · View at Google Scholar
  • Anna Szumilewicz, Aneta Worska, Magdalena Piernicka, Agnieszka Kuchta, Zbigniew Jastrzębski, Łukasz Radzimiński, Marta Kozłowska, Katarzyna Micielska, and Ewa Ziemann, “Acute Postexercise Change in Circulating Irisin Is Related to More Favorable Lipid Profile in Pregnant Women Attending a Structured Exercise Program and to Less Favorable Lipid Profile in Controls: An Experimental Study with Two Groups,” International Journal of Endocrinology, vol. 2019, pp. 1–11, 2019. View at Publisher · View at Google Scholar
  • Ruoyi Liu, Lixin Shi, Nianchun Peng, Qiao Zhang, and Hong Li, “Higher Baseline Serum Irisin Decreases Risk for Body Mass Index Increment in Chinese Populations: A 3.2-Year Cohort Study,” Diabetes Therapy, 2019. View at Publisher · View at Google Scholar
  • Yeon Lee, Yoonseok Heo, Ji-Ho Choi, Sunghyouk Park, Kyoung Kim, Dong Shin, and Ju-Hee Kang, “Association of Circulating Irisin Concentrations with Weight Loss after Roux-en-Y Gastric Bypass Surgery,” International Journal of Environmental Research and Public Health, vol. 16, no. 4, pp. 660, 2019. View at Publisher · View at Google Scholar
  • Manuel F. Landecho, Carlota Tuero, Víctor Valentí, Idoia Bilbao, Magdalena de la Higuera, and Gema Frühbeck, “Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk,” Nutrients, vol. 11, no. 11, pp. 2664, 2019. View at Publisher · View at Google Scholar
  • Marwa M. Esawy, and Khalid M. Abdel-Samd, “The diagnostic and prognostic roles of serum irisin in bladder cancer,” Current Problems in Cancer, pp. 100529, 2019. View at Publisher · View at Google Scholar
  • Mehmet Calan, and Mustafa Demirpence, “Increased circulating levels of irisin are associated with cardiovascular risk factors in subjects with acromegaly,” Hormones, 2019. View at Publisher · View at Google Scholar
  • Hye Soo Chung, and Kyung Mook Choi, “Organokines in disease,” 2019. View at Publisher · View at Google Scholar
  • Jiannan Wu, Delong Jiao, Lingyan Cao, Xianzhen Xin, Ao Zheng, Yang Liu, and Xinquan Jiang, “Delivery vehicle of muscle-derived irisin based on silk/calcium silicate/sodium alginate composite scaffold for bone regeneration,” International Journal of Nanomedicine, vol. 14, pp. 1451–1467, 2019. View at Publisher · View at Google Scholar
  • Leila Nikniaz, Reza Mahdavi, and Nazanin Ommati, “Association of serum irisin levels with anthropometric, biochemical, and atherogenic indices in healthy adults,” Progress in Nutrition, vol. 21, no. 1, pp. 174–182, 2019. View at Publisher · View at Google Scholar