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International Journal of Endocrinology
Volume 2014 (2014), Article ID 902186, 8 pages
http://dx.doi.org/10.1155/2014/902186
Research Article

Irisin Enhances Osteoblast Differentiation In Vitro

1Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari, 70124 Bari, Italy
2Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy
3Department of Experimental and Clinical Medicine, Center of Obesity, United Hospitals—University of Ancona, 60020 Ancona, Italy

Received 19 December 2013; Accepted 13 January 2014; Published 4 March 2014

Academic Editor: Nicola Napoli

Copyright © 2014 Graziana Colaianni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [35 citations]

The following is the list of published articles that have cited the current article.

  • Kanogwun Thongchote, Saovaros Svasti, Jarinthorn Teerapornpuntakit, Nateetip Krishnamra, and Narattaphol Charoenphandhu, “Running exercise alleviates trabecular bone loss and osteopenia in hemizygous beta-globin knockout thalassemic mice,” American Journal of Physiology-Endocrinology and Metabolism, vol. 306, no. 12, pp. E1406–E1417, 2014. View at Publisher · View at Google Scholar
  • Vibha Singhal, Elizabeth A. Lawson, Kathryn E. Ackerman, Pouneh K. Fazeli, Hannah Clarke, Hang Lee, Kamryn Eddy, Dean A. Marengi, Nicholas P. Derrico, Mary L. Bouxsein, and Madhusmita Misra, “Irisin Levels Are Lower in Young Amenorrheic Athletes Compared with Eumenorrheic Athletes and Non-Athletes and Are Associated with Bone Density and Strength Estimates,” Plos One, vol. 9, no. 6, 2014. View at Publisher · View at Google Scholar
  • Haibo Song, Lijun Yang, Xing Li Wang, Taixing Cui, Dongqi Tang, Fei Wu, Yuan Zhang, Yuzhu Zhang, Fang Wang, Miao Jiang, Zhongde Wang, Mingxiang Zhang, and Shiwu Li, “Irisin promotes human umbilical vein endothelial cell proliferation through the ERK signaling pathway and partly suppresses high glucose-induced apoptosis,” PLoS ONE, vol. 9, no. 10, 2014. View at Publisher · View at Google Scholar
  • Graziana Colaianni, Concetta Cuscito, Teresa Mongelli, Paolo Pignataro, Cinzia Buccoliero, Peng Liu, Ping Lu, Loris Sartini, Mariasevera Di Comite, Giorgio Mori, Adriana Di Benedetto, Giacomina Brunetti, Tony Yuen, Li Sun, Janne E. Reseland, Silvia Colucci, Maria I. New, Mone Zaidi, Saverio Cinti, and Maria Grano, “The myokine irisin increases cortical bone mass,” Proceedings Of The National Academy Of Sciences Of The United States Of America, vol. 112, no. 39, pp. 12157–12162, 2015. View at Publisher · View at Google Scholar
  • Fei Wu, Haibo Song, Yuan Zhang, Yuzhu Zhang, Qian Mu, Miao Jiang, Fang Wang, Wen Zhang, Liang Li, Huanjie Li, Yunshan Wang, Mingxiang Zhang, Shiwu Li, Lijun Yang, Yan Meng, and Dongqi Tang, “Irisin Induces Angiogenesis in Human Umbilical Vein Endothelial Cells In Vitro and in Zebrafish Embryos In Vivo via Activation of the ERK Signaling Pa,” Plos One, vol. 10, no. 8, 2015. View at Publisher · View at Google Scholar
  • Ning Chen, Qingxue Li, Jun Liu, and Shaohui Jia, “Irisin, an exercise-induced myokine as a metabolic regulator: an updated narrative review,” Diabetes/Metabolism Research and Reviews, 2015. View at Publisher · View at Google Scholar
  • Naoyuki Kawao, and Hiroshi Kaji, “Interactions Between Muscle Tissues and Bone Metabolism,” Journal of Cellular Biochemistry, vol. 116, no. 5, pp. 687–695, 2015. View at Publisher · View at Google Scholar
  • Wan-Yu He, Qiong Bai, La-Ta A, Chao-Shu Tang, and Ai-Hua Zhang, “Irisin levels are associated with urotensin II levels in diabetic patients,” Journal of Diabetes Investigation, 2015. View at Publisher · View at Google Scholar
  • Ping Kwan, “Osteoporosis: from osteoscience to neuroscience and beyond,” Mechanisms of Ageing and Development, 2015. View at Publisher · View at Google Scholar
  • Graziana Colaianni, and Maria Grano, “Role of Irisin on the bone–muscle functional unit,” BoneKEy Reports, vol. 4, pp. 765, 2015. View at Publisher · View at Google Scholar
  • Giovanni Lombardi, Fabian Sanchis-Gomar, Silvia Perego, Veronica Sansoni, and Giuseppe Banfi, “Implications of exercise-induced adipo-myokines in bone metabolism,” Endocrine, 2015. View at Publisher · View at Google Scholar
  • Michaël R. Laurent, Vanessa Dubois, Frank Claessens, Sabine M.P. Verschueren, Dirk Vanderschueren, Evelien Gielen, and Ferran Jardí, “Muscle-bone interactions: From experimental models to the clinic? A critical update,” Molecular and Cellular Endocrinology, 2015. View at Publisher · View at Google Scholar
  • Andrea Palermo, Rocky Strollo, Ernesto Maddaloni, Dario Tuccinardi, Luca D'Onofrio, Silvia Irina Briganti, Giuseppe Defeudis, Mariangela De Pascalis, Maria Concetta Lazzaro, Georgia Colleluori, Silvia Manfrini, Paolo Pozzilli, and Nicola Napoli, “Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity,” Clinical Endocrinology, 2015. View at Publisher · View at Google Scholar
  • Michaela Tencerova, and Moustapha Kassem, “The Bone Marrow-Derived Stromal Cells: Commitment and Regulation of Adipogenesis,” Frontiers in Endocrinology, vol. 7, 2016. View at Publisher · View at Google Scholar
  • G. Colaianni, T. Mongelli, S. Colucci, S. Cinti, and M. Grano, “Irisina, osso e muscolo,” L'Endocrinologo, 2016. View at Publisher · View at Google Scholar
  • Yuan Zhang, Yousong Ding, Dongqi Tang, Li-Jun Yang, Chao Xie, Hai Wang, Robin M. Foss, Eva Vertes George, Westley H. Reeves, Morgan Clare, Shiwu Li, Adam Katz, and Henrique Cheng, “Irisin exerts dual effects on browning and adipogenesis of human white adipocytes,” American Journal of Physiology - Endocrinology and Metabolism, vol. 311, no. 2, pp. E530–E541, 2016. View at Publisher · View at Google Scholar
  • Hiroshi Kaji, “Effects of myokines on bone,” BoneKEy Reports, vol. 5, pp. 826, 2016. View at Publisher · View at Google Scholar
  • Min-Tser Liao, Wen-Chih Liu, Fu-Huang Lin, Ching-Feng Huang, Shao-Yuan Chen, Chuan-Chieh Liu, Shih-Hua Lin, Kuo-Cheng Lu, and Chia-Chao Wu, “Intradialytic aerobic cycling exercise alleviates inflammation and improves endothelial progenitor cell count and bone density in hemodialysis patients,” Medicine, vol. 95, no. 27, pp. e4134, 2016. View at Publisher · View at Google Scholar
  • G. Colaianni, T. Mongelli, S. Colucci, S. Cinti, and Maria Grano, “Crosstalk Between Muscle and Bone Via the Muscle-Myokine Irisin,” Current Osteoporosis Reports, 2016. View at Publisher · View at Google Scholar
  • Nerly Deyanira Montañez Supelano, Darío Yesid Peña Ballesteros, and Hugo Armando Estupiñán Durán, “Dielectric and biochemical response of a PLA-PGA-HAp-Chitosan-Collagen coated on Ti6Al4V,” Ingeniare, vol. 24, no. 2, pp. 215–227, 2016. View at Publisher · View at Google Scholar
  • Baosheng Guo, Zong-Kang Zhang, Chao Liang, Jie Li, Jin Liu, Aiping Lu, Bao-Ting Zhang, and Ge Zhang, “Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism,” Calcified Tissue International, 2016. View at Publisher · View at Google Scholar
  • Shanshan Gao, Yan Cheng, Lingling Zhao, Yuxin Chen, and Yu Liu, “The relationships of irisin with bone mineral density and body composition in PCOS patients,” Diabetes/Metabolism Research and Reviews, vol. 32, no. 4, pp. 421–428, 2016. View at Publisher · View at Google Scholar
  • Xiao Yong Qiao, Ying Nie, Ya Xian Ma, Yan Chen, Ran Cheng, Wei Yao Yinrg, Ying Hu, Wen Ming Xu, and Liang Zhi Xu, “Irisin promotes osteoblast proliferation and differentiation via activating the MAP kinase signaling pathways,” Scientific Reports, vol. 6, pp. 18732, 2016. View at Publisher · View at Google Scholar
  • Yaprak Engin-Üstün, Emel Kıyak Çağlayan, Ayşe Yeşim Göçmen, and Muhammed Fevzi Polat, “Postmenopausal Osteoporosis Is Associated with Serum Chemerin and Irisin but Not with Apolipoprotein M Levels,” Journal of Menopausal Medicine, vol. 22, no. 2, pp. 76, 2016. View at Publisher · View at Google Scholar
  • Silvio Buscemi, Davide Corleo, Carola Buscemi, and Carla Giordano, “Does iris(in) bring bad news or good news?,” Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, 2017. View at Publisher · View at Google Scholar
  • Annalisa Natalicchio, Nicola Marrano, Giuseppina Biondi, Rosaria Spagnuolo, Rossella Labarbuta, Immacolata Porreca, Angelo Cignarelli, Marco Bugliani, Piero Marchetti, Sebastio Perrini, Luigi Laviola, and Francesco Giorgino, “The Myokine Irisin Is Released in Response to Saturated Fatty Acids and Promotes Pancreatic β-Cell Survival and Insulin Secretion,” Diabetes, vol. 66, no. 11, pp. 2849–2856, 2017. View at Publisher · View at Google Scholar
  • Graziana Colaianni, Teresa Mongelli, Concetta Cuscito, Paolo Pignataro, Luciana Lippo, Giovanna Spiro, Angela Notarnicola, Ilenia Severi, Giovanni Passeri, Giorgio Mori, Giacomina Brunetti, Biagio Moretti, Umberto Tarantino, Silvia C. Colucci, Janne E. Reseland, Roberto Vettor, Saverio Cinti, and Maria Grano, “Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Young-Eun Park, David S Musson, Dorit Naot, and Jillian Cornish, “Cell–cell communication in bone development and whole-body homeostasis and pharmacological avenues for bone disorders,” Current Opinion in Pharmacology, vol. 34, pp. 21–35, 2017. View at Publisher · View at Google Scholar
  • Yiwen Qin, Yuanzhen Peng, Wei Zhao, Jianping Pan, Hanna Ksiezak-Reding, Christopher Cardozo, Yingjie Wu, Paola Divieti Pajevic, Lynda F. Bonewald, William A. Bauman, and Weiping Qin, “Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218: A novel mechanism in muscle-bone communication,” Journal of Biological Chemistry, vol. 292, no. 26, pp. 11021–11033, 2017. View at Publisher · View at Google Scholar
  • Graziana Colaianni, Saverio Cinti, Silvia Colucci, and Maria Grano, “Irisin and musculoskeletal health,” Annals of the New York Academy of Sciences, 2017. View at Publisher · View at Google Scholar
  • Jun Yan, Hai-Juan Liu, Wei-Chun Guo, and Jian Yang, “Low serum concentrations of Irisin are associated with increased risk of hip fracture in Chinese older women,” Joint Bone Spine, 2017. View at Publisher · View at Google Scholar
  • Charles L. Wood, Paola Divieti Pajevic, and Jonathan H. Gooi, “Osteocyte secreted factors inhibit skeletal muscle differentiation,” Bone Reports, 2017. View at Publisher · View at Google Scholar
  • Jin Zhang, Paloma Valverde, Xiaofang Zhu, Dana Murray, Yuwei Wu, Liming Yu, Hua Jiang, Michel M Dard, Jin Huang, Zhiwei Xu, Qisheng Tu, and Jake Chen, “Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism,” Bone Research, vol. 5, pp. 16056, 2017. View at Publisher · View at Google Scholar
  • Stergios A. Polyzos, Athanasios D. Anastasilakis, Zoe A. Efstathiadou, Polyzois Makras, Nikolaos Perakakis, Jannis Kountouras, and Christos S. Mantzoros, “Irisin in metabolic diseases,” Endocrine, 2017. View at Publisher · View at Google Scholar
  • Delphine Maurel, Katharina Jähn, and Nuria Lara-Castillo, “Muscle–Bone Crosstalk: Emerging Opportunities for Novel Therapeutic Approaches to Treat Musculoskeletal Pathologies,” Biomedicines, vol. 5, no. 4, pp. 62, 2017. View at Publisher · View at Google Scholar