The Importance of the Prenyl Group in the Activities of Osthole in Enhancing Bone Formation and Inhibiting Bone Resorption In Vitro

Figure 11

Effects of treatment with 10⁻⁵ M 7-methoxycoumarin or osthole or neither (control) on TRAP activity in cultured rabbit osteoclasts in 𝛼-MEM containing 15% FBS and 10⁻⁸ M 1,25(OH)₂D₃. TRAP activity was expressed as the absorbance value at 530 nm. Data were shown as mean ± SD of triplicate cultures. ^∗𝑃<0.05, ^∗∗𝑃<0.01 versus control; ^#𝑃<0.05, ^##𝑃<0.01 versus 7-methoxycoumarin.