Basal-Supported Oral Therapy with Sitagliptin Counteracts Rebound Hyperglycemia Caused by GLP-1 Tachyphylaxis

Table 2

Differences of parameters between baseline and after 5 months of treatment.

	Baseline (n = 15)	5 months (n = 15)
Prior therapy
Liraglutide (n)	9
Exenatide (n)	6
Study medications
Insulin glargine (n)	15	15
units/day	11.7 ± 4.5	10.4 ± 3.6
Sitagliptin (n)	15	15
25 mg/day	1	1
100 mg/day	14	14
Glimepiride (n)	15	15
mg/day	2.9 ± 1.8	2.8 ± 1.7
Metformin (n)	8	8
mg/day	1400	1325
Pioglitazone (n)	6	6
mg/day	27.5 ± 11.3	27.5 ± 11.3