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International Journal of Endocrinology
Volume 2014, Article ID 954045, 9 pages
http://dx.doi.org/10.1155/2014/954045
Research Article

The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach

1Department of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, Turkey
2Department of İnternal Medicine, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Turkey
3Department of Cardiology, İstinye State Hospital, Turkey
4Department of Biochemistry, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Turkey

Received 31 July 2014; Revised 1 October 2014; Accepted 1 October 2014; Published 2 November 2014

Academic Editor: Mario Maggi

Copyright © 2014 Bulent Demir et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The risk for cardiovascular diseases and type 2 diabetes mellitus significantly increases in the patient population with metabolic syndrome (MeS). The present study aimed to investigate the association between the epicardial adipose tissue thickness (EATT) and the oxidative stress parameters in MeS patients. The study included 181 patients as a patient group of 92 consecutive patients with MeS and a control group of 89 consecutive patients with similar age and gender. EATT was evaluated by transthoracic echocardiography. Serum levels of total oxidant status (TOS), total antioxidative capacity (TAS), paraoxonase-1 (PON-1), and arylesterase activities were measured. EATT was higher in the MeS group compared to the control group ( mm and  mm, resp.; ). The level of TOS was higher in the MeS group compared to the control group (). Additionally, the TAS level was higher in the MeS group compared to the control group (). Furthermore, the serum levels of PON-1 and arylesterase were lower in the MeS group compared to the control group (). EAT may cause an increased risk of cardiovascular diseases by leading to increased oxidative stress in patients with MeS.