International Journal of Endocrinology / 2014 / Article / Tab 1

Research Article

High Prevalence of Infertility among Women with Graves’ Disease and Hashimoto’s Thyroiditis

Table 1

Characteristics of the women with GD and HT who reported or did not report a period of infertility.

CharacteristicsInfertilityNo infertility value

Graves’ disease 101 (52.3)92 (47.7)
Agea44.3 (9.4)42.2 (9.3)NSb
Age at menarche (years)a12.8 (1.8)12.6 (1.6)NSb
Age at sexual debut (years)a17.6 (3.8)17.5 (3.7)NSb
Age at diagnosis (years)a36.5 (9.8)35.8 (9.1)NSb
Time of the disease (years)a7.8 (5.9)6.3 (4.6)NSb
Exophthalmos 57 (56.4)60 (65.2)NSc
Goiter volume (cm3)a26.4 (22.2)26.2 (18.9)NSa
Thyroid nodule28 (31.4)25 (29.7)NSc
Anti-TPO 87 (87.9)72 (84.7)NSc
Anti-Tg 61 (61.6)52 (58.4)NSc
Other autoimmune diseases11 (10.9)11 (11.9)NSc
Family history of thyroid disease
 Graves’ disease14 (13.8)14 (15.5)NSc
 Hashimoto’s thyroiditis13 (12.8)7 (7.8)NSc
Family history of other autoimmune diseases 47 (46.5)38 (42.2)NSc
Hashimoto’s thyroiditis 31 (47.0)35 (53.0)
Age (years)a44.7 (10.4)46.2 (10.8)NSb
Age at menarche (years)a12.4 (2.0)12.4 (1.6)NSb
Age at sexual debut (years)a18.5 (3.8)17.4 (3.1)NSb
Age at diagnosis (years)a39.2 (10.6)37.1 (11.4)NSb
Time of the disease (years)a5.5 (4.2)9.1 (5.6)0.004b
Goiter10 (33.3)13 (39.4)NSc
Goiter volume (cm3)a17.8 (22.3)16.3 (11.8)NSb
Thyroid nodule15 (50.0)10 (30.3)NSc
Anti-TPO 27 (90.0)33 (94.3)NSd
Anti-Tg 27 (87.1)29 (82.8)NSd
Other autoimmune diseases4 (12.9)3 (8.6)NSd
Family history of thyroid disease
 Graves’ disease2 (6.7)5 (14.3)NSd
 Hashimoto’s thyroiditis11 (36.7)10 (28.6)NSc
Family history of other autoimmune diseases18 (60.0)18 (51.4)NSc

“Infertility” and “No infertility” groups refer, respectively, to the group of women who reported a period of infertility and the group of women who did not.
NS: not significant; values consist of means ± standard deviation of the mean; Mann-Whitney test; chi-square test; Fisher’s exact test; anti-TPO: antithyroid peroxidase antibodies; anti-Tg: antithyroglobulin antibodies.

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