Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan

Table 1

Clinical and metabolic features between normal controls and type 2 diabetic subjects in the present study.

	Non-DM ()	DM ()	value*
Age (years)	17.3 ± 3.8	18.6 ± 6.6	0.289
BMI percentiles	56.7 ± 29.0	83.8 ± 15.4	<0.001
Glucose (mmol/L)	5.19 ± 0.40	10.65 ± 4.05	<0.001
TCH (mmol/L)	4.05 ± 0.77	4.22 ± 1.02	0.4159
TG (mmol/L)	0.74 ± 0.26	1.17 ± 0.45	0.0005
HDL (mmol/L)	1.43 ± 0.39	1.20 ± 0.50	0.0320
Fasting insulin (pmol/L)	7.66 ± 4.47	17.99 ± 20.43	0.0043
HOMA-IR	1.78 ± 1.06	7.48 ± 8.09	<0.001
Log (HOMA-IR)	0.402 ± 0.624	1.449 ± 1.143	<0.001
HOMA-B	94.62 ± 58.17	94.13 ± 168.52	0.987
Log (HOMA-B)	4.372 ± 0.625	3.490 ± 1.458	0.001
Sex (M : F)	26 : 43	20 : 18	0.157^$

value with Student’s -test.
^$By chi-squared test.
BMI percentiles: body mass index age- and sex-specific percentiles; TCH: total cholesterol; TG: triglyceride; HDL: high density lipoprotein-cholesterol; HOMA-IR: homeostasis model assessment-insulin resistance; HOMA-B: homeostasis model assessment-β cell.