International Journal of Endocrinology / 2014 / Article / Tab 1

Research Article

Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan

Table 1

Clinical and metabolic features between normal controls and type 2 diabetic subjects in the present study.

Non-DM ()DM () value*

Age (years)17.3 ± 3.818.6 ± 6.60.289
BMI percentiles56.7 ± 29.083.8 ± 15.4<0.001
Glucose (mmol/L)5.19 ± 0.4010.65 ± 4.05<0.001
TCH (mmol/L)4.05 ± 0.774.22 ± 1.020.4159
TG (mmol/L)0.74 ± 0.261.17 ± 0.450.0005
HDL (mmol/L)1.43 ± 0.391.20 ± 0.500.0320
Fasting insulin (pmol/L)7.66 ± 4.4717.99 ± 20.430.0043
HOMA-IR1.78 ± 1.067.48 ± 8.09<0.001
Log (HOMA-IR)0.402 ± 0.6241.449 ± 1.143<0.001
HOMA-B94.62 ± 58.1794.13 ± 168.520.987
Log (HOMA-B)4.372 ± 0.6253.490 ± 1.4580.001
Sex (M : F)26 : 4320 : 180.157$

value with Student’s -test.
$By chi-squared test.
BMI percentiles: body mass index age- and sex-specific percentiles; TCH: total cholesterol; TG: triglyceride; HDL: high density lipoprotein-cholesterol; HOMA-IR: homeostasis model assessment-insulin resistance; HOMA-B: homeostasis model assessment-β cell.