Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan

Table 3

Logistic regression analysis with type 2 diabetic status as dependent variables, age, sex, BMI age- and sex-specific percentiles, and genotype of E23K polymorphism in Kir6.2 as independent variables.


Independent variables	Odds ratio	95% CI	value

Model 1
EK/KK versus EE	2.941	0.764–11.323	0.117
Age (every 1 year increment)	1.156	0.920–1.454	0.214
Sex (male = 1, female = 2)	0.672	0.224–2.019	0.479
BMI age- and sex-specific percentiles (every 1 percentile increment)	1.060	1.027–1.094	<0.001
Model 2
EK/KK versus EE	4.105	1.0008–16.831	0.047
Age (every 1 year increment)	1.240	0.960–1.601	0.099
Sex (male = 1, female = 2)	0.826	0.252–2.711	0.752
BMI age- and sex-specific percentiles (every 1 percentile increment)	1.047	1.014–1.080	0.004
Fasting plasma insulin levels (every 1 pmol/L increment)	1.066	1.001–1.135	0.045

International Journal of Endocrinology

Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan

Table 3