International Journal of Endocrinology / 2014 / Article / Tab 3

Research Article

Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan

Table 3

Logistic regression analysis with type 2 diabetic status as dependent variables, age, sex, BMI age- and sex-specific percentiles, and genotype of E23K polymorphism in Kir6.2 as independent variables.

Independent variablesOdds ratio95% CI value

Model 1
 EK/KK versus EE2.9410.764–11.3230.117
 Age (every 1 year increment)1.1560.920–1.4540.214
 Sex (male = 1, female = 2)0.6720.224–2.0190.479
 BMI age- and sex-specific percentiles (every 1 percentile increment)1.0601.027–1.094<0.001
Model 2
 EK/KK versus EE4.1051.0008–16.8310.047
 Age (every 1 year increment)1.2400.960–1.6010.099
 Sex (male = 1, female = 2)0.8260.252–2.7110.752
 BMI age- and sex-specific percentiles (every 1 percentile increment)1.0471.014–1.0800.004
 Fasting plasma insulin levels (every 1 pmol/L increment)1.0661.001–1.1350.045