Augmented β-Cell Function and Mass in Glucocorticoid-Treated Rodents Are Associated with Increased Islet Ir-β/AKT/mTOR and Decreased AMPK/ACC and AS160 Signaling

Figure 1

DEX treatment induces a reduction in insulin sensitivity in mice and in rats but increases hepatic gluconeogenesis and glucose intolerance only in rats. ((a), (f)) Blood glucose during intraperitoneal insulin tolerance test (ipITT; 1 U/Kg b.w.) in DEX-treated mice and rats, respectively; the inset in (a) and (f) depicts the constant rate of glucose disappearance (KITT). ((b), (g)) Intraperitoneal pyruvate tolerance test (ipPTT; 1 g/Kg b.w.) in DEX-treated mice and rats, respectively; the inset in (b) and (g) depicts the ipPTT data normalized by minute 0 ((c), (h)) A.U.C and ((d), (i)) the constant rate of glucose appearance (KPTT) during ipPTT in DEX-treated mice and rats, respectively. ((e), (j)) intraperitoneal glucose tolerance test (ipGTT; 1 g/Kg b.w.) in DEX-treated mice and rats, respectively; the inset in (e) and (j) depicts the A.U.C. from ipGTT; values are mean ± S.E.M.; 8–10 animals per group. Significantly different compared to CTL. Unpaired Student’s -test, .