Augmented β-Cell Function and Mass in Glucocorticoid-Treated Rodents Are Associated with Increased Islet Ir-β/AKT/mTOR and Decreased AMPK/ACC and AS160 Signaling
Figure 3
DEX treatment increases β-cell mass in the pancreas of mice and rats. (a) Representative pancreas sections stained for insulin with Hematoxylin counterstaining. (b) Pancreas weight, (c) relative islet number per pancreas area, (d) relative β-cell area per pancreas area, and (e) absolute β-cell mass in DEX-treated mice and rats. Values are mean ± S.E.M.; 5-6 animals per group (≈150 islets from mice and ≈300 islets from rats). Significantly different compared to CTL. Unpaired Student’s -test, .
