Augmented β-Cell Function and Mass in Glucocorticoid-Treated Rodents Are Associated with Increased Islet Ir-β/AKT/mTOR and Decreased AMPK/ACC and AS160 Signaling

Figure 5

DEX treatment stimulates the canonical insulin pathway and inhibits the noncanonical insulin pathway in pancreatic islets from mice and rats. (a) Representative immunoblotting of phosphorylated and (b) total Ir-β content. (c) Phosphorylated and (d) total AKT content. (e) Phosphorylated and (f) total ERK content. (g) Phosphorylated and (h) total AMPK content. (i) Phosphorylated and (j) total ACC content in islets from DEX-treated mice and rats. Values are mean ± S.E.M.; rodents per group. Significantly different compared to CTL. Unpaired Student’s -test, .