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International Journal of Endocrinology
Volume 2015 (2015), Article ID 136810, 9 pages
http://dx.doi.org/10.1155/2015/136810
Research Article

Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid Carcinoma

1Department of Pathology, Zhejiang Province Cancer Hospital, Hangzhou 310022, China
2Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
3Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou 310022, China
4Department of Head and Neck Surgery, Zhejiang Province Cancer Hospital, Hangzhou 310022, China

Received 16 December 2014; Revised 11 February 2015; Accepted 5 March 2015

Academic Editor: Sabrina Corbetta

Copyright © 2015 Jin-lin Hu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

ATM and γH2AX play a vital role in the detection of DNA double-strand breaks (DSB) and DNA damage response (DDR). This study aims to investigate ATM and γH2AX expression in thyroid cancer and discuss possible relationship between thyroid function tests and DNA damage. The expression of ATM and γH2AX was detected by immunohistochemistry in 30 cases of benign nodular goiter, 110 cases of well differentiated thyroid cancer, 22 cases of poorly differentiated thyroid cancer, and 21 cases of anaplastic thyroid cancer. Clinicopathological features, including differentiation stages, distant metastasis, lymph node metastasis, T classification, TNM stage, and tests of thyroid functions (TPOAb, Tg Ab, T3, FT3, T4, FT4, TSH, and Tg), were reviewed and their associations with γH2AX and ATM were analyzed. γH2AX and ATM expressed higher in thyroid cancer tissues than in benign nodular goiter and normal adjacent tissues. γH2AX was correlated with ATM in thyroid cancer. Both γH2AX and ATM expression were associated with FT3. γH2AX was also associated with T classification, TNM stage, FT4, TSH, and differentiation status. Therefore both of ATM and γH2AX seem to correlate with thyroid hormones and γH2AX plays a role in the differentiation status of thyroid cancer.