Urinary Angiopoietin-2 Is Associated with Albuminuria in Patients with Type 2 Diabetes Mellitus
Serum and urinary angiogenic growth factor levels in diabetic patients and controls. (a) Statistical analysis showed increased serum concentrations of Ang-2 in diabetic patients compared with controls. (b) The level of urinary Ang-2 showed a stepwise increase in diabetic patients compared to controls according to the degree of albuminuria. (c) Urinary Ang-1 level was significantly higher in the DN1 group and lower in the DN3 group when compared with control subjects. Patients in the DN1 and DN2 groups exhibited significantly higher urinary Ang-1 levels than those in the DN3 group. (d) Subjects with diabetes mellitus showed significantly higher urinary VEGF levels than control subjects. Patients were divided into DN1 (normal-albuminuria), DN2 (microalbuminuria), and DN3 (macroalbuminuria) groups. versus NC; versus NC; versus DN1; versus DN2.
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